| Regent ST James Limited | Construction | 2021 |
| Regi International Limited | Wholesale & retail | 1991 |
| Renata & Dorina Limited | Health & social care | 2017 |
| Renovo Car Care Ltd | Administrative & support | 2025 |
| Renovo Number Plates Ltd | Wholesale & retail | 2025 |
| Rentacabin Limited | Other services | 2011 |
| Reprack Fitness Ltd | Arts & recreation | 2025 |
| Rerooters Limited | Administrative & support | 2025 |
| Resitech Solutions Limited | Information & communication | 2025 |
| Revelo Property Limited | Real estate | 2025 |
| Revelo Resolve Limited | Professional & scientific | 2025 |
| RG Specialist Solutions Limited | Education | 2015 |
| Richardson Design Associates Limited | Professional & scientific | 2026 |
| Ridgewell Waterproofing & Construction Group Ltd | Construction | 2020 |
| Right UP OUR Street Ltd | Households | 2013 |
| Risbygate Developments Limited | Real estate | 2024 |
| River CAM Holdings Limited | Real estate | 2024 |
| RJ Design Hive Ltd | Information & communication | 2025 |
| RJB Transport Consultants Limited | Professional & scientific | 2025 |
| RKR Holdings Limited | Financial services | 2024 |
| RM Business Management Solutions Limited | Professional & scientific | 2013 |
| RMS Associated Limited | Professional & scientific | 2023 |
| RMS Works Ltd | Wholesale & retail | 2025 |
| Robert Cowell Limited | Financial services | 2019 |
| Roman Technology Limited | Information & communication | 2010 |
| Roobert Properties Limited | Real estate | 2021 |
| ROOM4 Haverhill Community Interest Company | Health & social care | 2020 |
| Rostock Properties Limited | Real estate | 2019 |
| Rotem Limited | Wholesale & retail | 1993 |
| Rowlinson Commercial & Industrial Services Ltd | Administrative & support | 2018 |
| Royce Group Ltd. | Construction | 1984 |
| RP & TC Investments Ltd | Real estate | 2018 |
| Rpms Auto Parts Ltd | Wholesale & retail | 2018 |
| Rubine Investments Ltd | Real estate | 2019 |
| Ruby Scaffolding Services Ltd | Construction | 2023 |
| RWC Group Ltd | Construction | 2025 |
| Rylands Farms Holdings Limited | Financial services | 2021 |
| S & DG Holdings Ltd | Real estate | 2026 |
| S G Electrical(Suffolk) Ltd | Construction | 2012 |
| S Haynes Transport Limited | Transport & logistics | 2016 |
| S J H Chiropractic Ltd | Health & social care | 2015 |
| S J W Technical Services Limited | Professional & scientific | 2017 |
| S&P Electrical Services Ltd | Professional & scientific | 2014 |
| S.H.R. Business Holdings Limited | Financial services | 2012 |
| Saajfoods Ltd | Hospitality | 2008 |
| Safe and Well Together Limited | Professional & scientific | 2012 |
| Sagia Limited | Health & social care | 2015 |
| Sala Therapy Haverhill Ltd | Other services | 2022 |
| Salon Nine Hair & Beauty Ltd | Other services | 2021 |
| Sambex 1959 Limited | Extraterritorial | 2014 |
| Sand Beach Farm Ltd | Agriculture & fishing | 2024 |
| Sandcastle Playgroup Ltd | Education | 2004 |
| Sandrina Ltd | Wholesale & retail | 2020 |
| Saracens Filling Station Limited | Wholesale & retail | 1947 |
| SAS Swimming Ltd | Education | 2025 |
| SB Fire and Ice Ltd | Construction | 2026 |
| SBC Consultants Ltd | Professional & scientific | 2025 |
| Screenworks Ltd. | Manufacturing | 2001 |
| Scyne Ltd | Administrative & support | 2025 |
| SDG Custom Designs Limited | Wholesale & retail | 2023 |
| SDG Electrical Contractors Ltd | Construction | 2013 |
| Sebastian Tudor Ltd | Health & social care | 2019 |
| Segment Manufacturing Solutions Limited | Manufacturing | 2014 |
| Senti-Tech Services Ltd | Information & communication | 2023 |
| Serenity Leisure Ltd | Hospitality | 2020 |
| SES Consulting Limited | Administrative & support | 2001 |
| Seymour Property Solutions Ltd | Real estate | 2024 |
| Shine Bright Private Cleaners Ltd | Administrative & support | 2024 |
| Shore Hall Estate Limited | Agriculture & fishing | 1957 |
| Shot Design Limited | Professional & scientific | 2011 |
| SHY Cat Media Limited | Information & communication | 2010 |
| Siason Properties Ltd | Real estate | 2024 |
| Signum Law Limited | Professional & scientific | 2015 |
| Sinclair Animal and Household Care Limited | Manufacturing | 2002 |
| SJB Site Services Limited | Construction | 2010 |
| SKC Studios Limited | Information & communication | 2019 |
| Skelton Financial Services Limited | Financial services | 1987 |
| SKR Fire Protection Ltd | Construction | 2021 |
| Skyline Networks & Consultancy Ltd | Information & communication | 2003 |
| Skyweb Ventures Limited | Wholesale & retail | 2018 |
| Smart Alloys Limited | Wholesale & retail | 2020 |
| Smart R Distribution Ltd | Wholesale & retail | 2010 |
| Smiro Qualitas Ltd | Professional & scientific | 2012 |
| Smiro Qualitas Manufacturing Ltd | Manufacturing | 2023 |
| Smtm Holding Limited | Professional & scientific | 2002 |
| Softforge Systems Ltd | Information & communication | 2025 |
| Solace Land Solutions Ltd | Real estate | 2025 |
| Solace Properties Limited | Real estate | 2024 |
| Solae (UK) Limited | Wholesale & retail | 1972 |
| Somas Food UK Ltd | Hospitality | 2024 |
| Souhaitdedieu Limited | Health & social care | 2023 |
| SP Railway Engineering Ltd | Construction | 2022 |
| Spacemann Limited | Manufacturing | 1993 |
| Sperling Retail Limited | Manufacturing | 2009 |
| Spice & Seasoning International Ltd | Hospitality | 2014 |
| Sports Coatings Limited | Extraterritorial | 2016 |
| Spring Cottage Landscaping Limited | Administrative & support | 2006 |
| SRI Lankan Festival of Art & Culture Limited | Arts & recreation | 2025 |
| SS Property Group Partners Ltd | Construction | 2026 |
| SSG Pro Tech Automotive Ltd | Wholesale & retail | 2025 |