| Snowdrop Lane Developments Ltd | Construction | 2024 |
| Soci@Leyes Ltd | Information & communication | 2023 |
| Social MON Ltd | Professional & scientific | 2023 |
| Sofytex Ltd | Other services | 2021 |
| Solachine Trading Ltd | Wholesale & retail | 2023 |
| Solarflo Ltd | Wholesale & retail | 2011 |
| Solbury Poultry Limited | Agriculture & fishing | 2020 |
| Solution the Agency Ltd | Arts & recreation | 2008 |
| Solva & ST Davids Holiday Lets Ltd | Hospitality | 2019 |
| Solva Edge Festival Limited | Arts & recreation | 2016 |
| Solva Edge Trading Limited | Hospitality | 2018 |
| Solva Holiday Cottages Accommodation Ltd | Hospitality | 2019 |
| Solwr Ltd | Construction | 2022 |
| Sophisticated Asset Management Solutions Ltd | Extraterritorial | 2023 |
| Sorlolema Ltd | Extraterritorial | 2023 |
| SOS West Wales Limited | Transport & logistics | 2018 |
| Sotas Group Limited | Financial services | 2025 |
| Sotas Limited | Professional & scientific | 2022 |
| Soul Balm Ltd | Administrative & support | 2024 |
| Soul Path Freedom Ltd. | Extraterritorial | 2024 |
| Soul Touch Energy Ltd | Extraterritorial | 2025 |
| Soulful Energy Ltd | Administrative & support | 2024 |
| Soulmoon Ltd | Extraterritorial | 2024 |
| Soulpath Ltd | Administrative & support | 2022 |
| Sound and Balance Ltd | Administrative & support | 2024 |
| Space 2 Commercial Ltd | Real estate | 2016 |
| Spacespeak (UK) Limited | Information & communication | 2017 |
| Spirit & Balance Ltd | Extraterritorial | 2022 |
| Spirit House Ltd | Hospitality | 2023 |
| Spirit Impact Ltd | Administrative & support | 2024 |
| Spirit Nature Ltd | Administrative & support | 2022 |
| Spirit of HUM Ltd | Administrative & support | 2024 |
| Spirit of Soul Ltd | Administrative & support | 2024 |
| Spirit of the Universe Ltd | Extraterritorial | 2024 |
| Spiritheart Ltd | Extraterritorial | 2025 |
| SPL Plastering Group Ltd | Construction | 2018 |
| Spooly Designs Ltd | Manufacturing | 2016 |
| Square Circle Investments Ltd | Real estate | 2023 |
| Sricares Ltd | Financial services | 2023 |
| Srmex Ltd | Other services | 2022 |
| SS Accountancy & Book Keeping Limited | Professional & scientific | 2025 |
| Ssevans Plant Hire Limited | Administrative & support | 2025 |
| SSK Milford Haven Ltd | Hospitality | 2023 |
| Sssvat Ltd | Professional & scientific | 2020 |
| ST Botolphs Free Range Turkey Limited | Agriculture & fishing | 2020 |
| ST Botolphs Organic Turkey Limited | Agriculture & fishing | 2020 |
| ST Bride's Bay Cottages Ltd | Extraterritorial | 2025 |
| ST Brides Bay Trading Company Ltd | Agriculture & fishing | 2024 |
| ST Brides Inn Limited | Hospitality | 2019 |
| ST Davids Distillery Limited | Manufacturing | 2019 |
| ST Davids Peninsula Music and Arts C.I.C. | Information & communication | 2020 |
| ST Dera (Wales) Ltd | Households | 2011 |
| ST Dera Blenheim Limited | Real estate | 2022 |
| ST Dera Connaught Limited | Real estate | 2022 |
| ST Dera Dorchester Limited | Real estate | 2022 |
| ST Dera Montague Limited | Real estate | 2022 |
| ST Dera Portman Limited | Real estate | 2022 |
| ST Dera ST James Limited | Households | 2022 |
| ST Ishmaels Garden Supplies Limited | Wholesale & retail | 2016 |
| ST Thomas Surgery Limited | Health & social care | 2001 |
| ST. David's Cathedral Bookshop Limited | Wholesale & retail | 1990 |
| ST. Davids Cottages Management Company Limited | Real estate | 1992 |
| St.Davids Escape Room Limited | Arts & recreation | 2021 |
| Stack Rock Ltd | Professional & scientific | 2022 |
| Stackpole Home Farm Limited | Financial services | 2020 |
| Stage Clear LP | | 2022 |
| Stargaze Glamping Limited | Hospitality | 2021 |
| Station Discount Furniture Centre Limited(The) | Wholesale & retail | 1979 |
| Station Hire Limited | Administrative & support | 2020 |
| Station Self Drive Limited | Administrative & support | 2008 |
| Steamers Limited | Hospitality | 1988 |
| Steeplejack Properties Ltd | Administrative & support | 2017 |
| Stelfox Farms Limited | Agriculture & fishing | 2012 |
| Stephanie Allin Couture Ltd | Wholesale & retail | 1996 |
| Stephen M Jones Limited | Construction | 2003 |
| Stephen Ratsey Sailmakers Limited | Manufacturing | 2004 |
| Steve Allum Consulting Limited | Professional & scientific | 2019 |
| Steve Richards Construction Limited | Construction | 2003 |
| Steve Young Horsemanship Limited | Agriculture & fishing | 2021 |
| Stiwdio Owens Limited | Professional & scientific | 2020 |
| Stix Noodle Bar Ltd | Hospitality | 2025 |
| Storage 4 Self Storage Centre Limited | Transport & logistics | 2003 |
| Storage West Wales Ltd | Wholesale & retail | 2025 |
| Store-It Pembrokeshire Ltd | Transport & logistics | 2025 |
| Story MÔR CIC | Other services | 2025 |
| Strand Antiques Limited | Wholesale & retail | 2003 |
| Subnor Ltd | Other services | 2021 |
| Sue's Pantry Limited | Manufacturing | 2012 |
| Summers Works Ltd | Real estate | 2016 |
| Summerton Lettings Ltd | Real estate | 2014 |
| Summerton West Limited | Transport & logistics | 2025 |
| Sunrise Consulting International Ltd | Administrative & support | 2024 |
| SUP Guides Ltd | Arts & recreation | 2025 |
| Supervised Contact Limited | Health & social care | 2025 |
| Supporting People and Pets Through Opportunity and Training (Sppot) Community Interest Company | Education | 2013 |
| Suredetails Ltd | Information & communication | 2019 |
| Surfwhitesands Ltd | Wholesale & retail | 2014 |
| Sutex Ltd | Other services | 2021 |
| Sweet Home Alpaca CYF | Agriculture & fishing | 2020 |
| Swiffly Limited | Information & communication | 2020 |