| Stan Shis Enterprises Ltd | Transport & logistics | 2018 |
| Stanborough Scientific Limited | Financial services | 2017 |
| Stanor Group Limited | Professional & scientific | 2024 |
| Star Line Transportation Ltd | Transport & logistics | 2021 |
| Starcross Limited | Information & communication | 2014 |
| Starr 3D Creations Ltd | Wholesale & retail | 2025 |
| Starshake Ltd | Wholesale & retail | 2011 |
| Staunton on WYE Investments Limited | Financial services | 2022 |
| Stealth Cleaning Services Ltd | Administrative & support | 2025 |
| Stealth Logistics & Removals Ltd | Transport & logistics | 2025 |
| Stealth Logistics Ltd | Financial services | 2023 |
| Stealth Removals Ltd | Transport & logistics | 2025 |
| Stealth Waste Management Ltd | Water & waste | 2025 |
| Steel Frame Builds Ltd | Construction | 2018 |
| Steeple Morden Development Limited | Construction | 2024 |
| Steeps One Shot Ltd | Manufacturing | 2020 |
| Stefan & Sons Construction Limited | Construction | 2023 |
| Stefan James Building&Civil Engineering Ltd. | Construction | 2016 |
| Stellis Ltd | Wholesale & retail | 2025 |
| Stephen Crane & Associates Limited | Administrative & support | 2021 |
| Stepping Stones Day Care Centre Ltd | Health & social care | 2022 |
| Sterling Bright Ltd | Professional & scientific | 2014 |
| Stevens Transport Limited | Transport & logistics | 2008 |
| Stilton Gate Management Company Limited | Households | 2022 |
| Stip Transport Ltd | Transport & logistics | 2015 |
| STK IT Services Ltd | Information & communication | 2026 |
| Stockway Investments Limited | Real estate | 2022 |
| Stone Bars Ltd | Hospitality | 2019 |
| Storm Consulting Services LLP | | 2026 |
| STP Environmental Ltd. | Extraterritorial | 2023 |
| Strahil Ltd | Construction | 2015 |
| Stratify Tech Ltd | Information & communication | 2025 |
| Streak Studios Ltd | Information & communication | 2023 |
| Streben UK Ltd | Wholesale & retail | 2025 |
| Stretea Trans Limited | Transport & logistics | 2022 |
| Strictly Accounts and Finance Ltd | Financial services | 2014 |
| Stripout London Ltd | Construction | 2021 |
| Strong Build 27 Ltd | Construction | 2026 |
| Stuart Robinson Consultancy Limited | Professional & scientific | 2016 |
| Studholme Smart Homes Ltd | Professional & scientific | 2025 |
| Studio Beri Ltd | Other services | 2025 |
| Studio Chik Ltd | Professional & scientific | 2014 |
| Studio Meraki Limited | Professional & scientific | 2021 |
| Studio Savorium Limited | Arts & recreation | 2025 |
| Studio Twelve Pilates Ltd | Arts & recreation | 2025 |
| Study INT Ltd | Education | 2024 |
| Submerge Limited | Information & communication | 2014 |
| Subtilis Accountancy Ltd | Professional & scientific | 2018 |
| Sugar and Spice Hatfield Ltd | Hospitality | 2025 |
| Sugar Bliss Confections Ltd | Hospitality | 2024 |
| Sugar Mouse Limited | Extraterritorial | 2005 |
| SUK Edulink Limited | Professional & scientific | 2024 |
| Sukh Aanand Limited | Wholesale & retail | 2024 |
| Sultan Alkhedhair Ltd | Financial services | 2019 |
| Sumitt Holdings Ltd | Wholesale & retail | 2025 |
| Summerhouse PR Limited | Professional & scientific | 2014 |
| Summers & Winters Limited | Administrative & support | 2012 |
| Summit Civils Solutions Limited | Construction | 2025 |
| Sunbeam (UK) Ltd | Transport & logistics | 2009 |
| Sunny Franni Travel Limited | Administrative & support | 2013 |
| Sunnykem Limited | Public administration | 2025 |
| Sunshinesoft Consulting Limited | Information & communication | 2019 |
| Supply Drive Premium Ltd | Wholesale & retail | 2021 |
| Sure Smile Ltd | Health & social care | 2022 |
| Surface Mount Solutions Limited | Manufacturing | 2002 |
| Surfking Ltd | Administrative & support | 2017 |
| Surgiaesthetics Ltd | Wholesale & retail | 2025 |
| Survey Express Services (Holdings) Limited | Financial services | 2021 |
| Survey Express Services Ltd | Administrative & support | 2025 |
| Sushka.Driedfruits Limited | Manufacturing | 2026 |
| Sustain Coffee Project Ltd | Manufacturing | 2019 |
| Sustain Innovations Ltd | Professional & scientific | 2025 |
| Sustainable Futures Management Limited | Professional & scientific | 2024 |
| Sustainable Futures Projects Limited | Professional & scientific | 2024 |
| Sutherland Advisors Ltd | Professional & scientific | 2021 |
| SV Soft Solutions UK Ltd | Information & communication | 2025 |
| SVN Holdings Limited | Financial services | 2024 |
| Swag Organics Ltd | Wholesale & retail | 2017 |
| Swanfield Joinery Ltd | Manufacturing | 2022 |
| Swanland Water Products Limited | Wholesale & retail | 2021 |
| Swarni Arts Ltd | Arts & recreation | 2019 |
| Sweat Partners Limited | Arts & recreation | 2023 |
| Sweat Room Limited | Arts & recreation | 2012 |
| Sweet Kids Ltd | Wholesale & retail | 2017 |
| Sweet Spoon Ltd | Hospitality | 2024 |
| Swenga Group Ltd | Wholesale & retail | 2022 |
| Swift Click (GB) Limited | Hospitality | 2017 |
| Swift Decision Ltd | Administrative & support | 2008 |
| Swift IT Consulting PVT Ltd | Information & communication | 2017 |
| Swift Scanning Ltd | Health & social care | 2025 |
| Swift Tribe Ltd | Wholesale & retail | 2025 |
| Swiftheat Plumbing Solutions Ltd | Construction | 2023 |
| Swinn Leadership Coaching Limited | Administrative & support | 2023 |
| Switchgear- JCE Limited | Health & social care | 2022 |
| Swojas Software Limited | Information & communication | 2016 |
| Syambati IT Solutions Ltd | Information & communication | 2015 |
| SYL Limited | Health & social care | 2023 |
| Symeou Holdings LLP | | 2023 |
| Symphony Enterprises Ltd | Real estate | 2014 |
| Synapps Solutions Limited | Information & communication | 2003 |