| Deep-Rose Ltd | Hospitality | 2022 |
| Deeprose PUB Management Limited | Hospitality | 2023 |
| Defend Earth Limited | Administrative & support | 2020 |
| Delamere Oral Care Ltd | Health & social care | 2011 |
| Delta Green Environmental Design Limited | Professional & scientific | 2011 |
| Demand Creation Partners Limited | Professional & scientific | 2019 |
| Denim Research Limited | Professional & scientific | 2018 |
| Deux Amies Limited | Other services | 2023 |
| Devassist Limited | Professional & scientific | 2012 |
| DF Project Services Ltd | Information & communication | 2022 |
| DH Trees Ltd | Administrative & support | 2025 |
| Diamadent Limited | Health & social care | 2016 |
| Digisimple Consulting Group Ltd | Information & communication | 2015 |
| Dilemma Consultancy Limited | Health & social care | 2004 |
| Diligence First Limited | Professional & scientific | 2017 |
| Dimar Consultancy Ltd | Professional & scientific | 2026 |
| Dino Plumbing BG Limited | Construction | 2024 |
| Dinostore Sussex Limited | Transport & logistics | 2023 |
| Dinostore Trading Limited | Transport & logistics | 2019 |
| Ditchling Accountants and Advisors Limited | Professional & scientific | 2024 |
| Ditchling Flower and Gift Studio Limited | Wholesale & retail | 2023 |
| Ditchling Museum of Art + Craft | Arts & recreation | 2008 |
| Ditchling Museum Trading Limited | Wholesale & retail | 2024 |
| Ditfk Limited | Real estate | 2012 |
| DJS Window Magic Ltd | Administrative & support | 2009 |
| DML Finishes Ltd | Construction | 2019 |
| DN Seeker Limited | Health & social care | 2017 |
| Dome Construction Limited | Construction | 2023 |
| Dome Construction Services Limited | Professional & scientific | 2012 |
| Domestic Companions Ltd | Administrative & support | 2025 |
| Dorian Ltd | Other services | 2009 |
| DOS Security Systems Ltd | Information & communication | 2020 |
| Double P Consulting Ltd | Professional & scientific | 2025 |
| Downlands Management Ltd | Hospitality | 2026 |
| Downlands Property Ltd | Hospitality | 2026 |
| Downsmill Limited | Professional & scientific | 2009 |
| DPS Sussex Limited | Construction | 2005 |
| Dragon Event Services Ltd | Administrative & support | 2026 |
| Dragon Rock Pictures Ltd | Administrative & support | 2026 |
| Dram Dram Limited | Hospitality | 2008 |
| Drivepoint Commercial Limited | Professional & scientific | 2004 |
| Drivepoint Construction Limited | Construction | 1982 |
| Drivepoint Groundworks Limited | Professional & scientific | 2004 |
| Drivepoint Holdings Limited | Financial services | 1993 |
| Drivepoint Plant and Plant Hire Limited | Professional & scientific | 2004 |
| Drivepoint Properties and Developments Limited | Professional & scientific | 2004 |
| Drivepoint Sussex and South East Limited | Professional & scientific | 2004 |
| Drmk Ltd | Health & social care | 2017 |
| Drybrough Oral Care Ltd. | Health & social care | 2001 |
| Duevo Limited | Information & communication | 2025 |
| Dugard Consulting Limited | Construction | 2012 |
| Dust Corp Limited | Information & communication | 2020 |
| DUT18 Ltd | Real estate | 2019 |
| Duty CX Ltd | Professional & scientific | 2024 |
| Easton Property Investments Limited | Real estate | 2016 |
| Easytibetan CIC | Education | 2023 |
| Easytiger Ltd | Wholesale & retail | 2018 |
| EAT Drink Smile Ltd | Hospitality | 2014 |
| Ecoflowwaste Ltd | Water & waste | 2025 |
| Ediscene Ltd | Professional & scientific | 2025 |
| Educaitional Ventures Ltd | Professional & scientific | 2019 |
| Educate Ventures LLP | | 2019 |
| Education and Training Academy FE Ltd | Education | 2025 |
| Education and Training Academy Group Ltd | Education | 2021 |
| Education and Training Academy Ltd | Education | 2021 |
| Education and Training Awards Ltd | Education | 2025 |
| Edward Cozzi Ltd | Construction | 2022 |
| Edward GUY Limited | Information & communication | 2012 |
| Eftekhari Oral Care Ltd | Health & social care | 2007 |
| EGA Consulting Engineers Ltd | Professional & scientific | 2011 |
| EJC NIO Ltd | Construction | 2025 |
| EKT Consulting Ltd | Administrative & support | 2023 |
| EL Automechanic Ltd | Wholesale & retail | 2019 |
| Elamentuk Ltd | Manufacturing | 2023 |
| Eldcon Ltd | Professional & scientific | 2024 |
| Electric Lime Design Ltd | Professional & scientific | 2023 |
| Element Business Services Ltd | Administrative & support | 2018 |
| Elevator Installation Technicians Limited | Administrative & support | 2008 |
| Elite Cars (South East) Ltd | Transport & logistics | 2011 |
| Elite Choice Home Care Limited | Health & social care | 2012 |
| Ellis Sports Therapy Limited | Arts & recreation | 2021 |
| Elljess Investments Ltd | Financial services | 2014 |
| Elmhouse Consultancy Limited | Professional & scientific | 2016 |
| Emma Forman Ltd | Other services | 2018 |
| Emma Lindsay Ltd | Professional & scientific | 2023 |
| Emplawyer Limited | Extraterritorial | 1999 |
| Empower EBT Ltd | Professional & scientific | 2021 |
| EMS Investments Ltd | Wholesale & retail | 2021 |
| Emzedco Ltd | Professional & scientific | 2006 |
| Enviromon Limited | Manufacturing | 2017 |
| Eportia Limited | Professional & scientific | 2012 |
| Equine Performance Thermography Limited | Professional & scientific | 2023 |
| Erinvale Advisory Ltd | Financial services | 2025 |
| Eskico Limited | Other services | 2019 |
| Essential Chiropractic Limited | Health & social care | 2007 |
| Etch Solutions Limited | Other services | 2025 |
| Euromech Systems Limited | Manufacturing | 2003 |
| Evergreen Rural Ltd | Agriculture & fishing | 2023 |
| Evolution Carpentry Limited | Manufacturing | 2019 |
| Evolution Flooring Limited | Construction | 2024 |