| ENC Construction Ltd | Construction | 2024 |
| Encee Investment Limited | Real estate | 2012 |
| Encelo Laboratories Limited | Professional & scientific | 2017 |
| Enchanted Diamonds Ltd | Wholesale & retail | 2025 |
| Enchanted Secrets Ltd | Other services | 2018 |
| Enchantia Ltd | Wholesale & retail | 2023 |
| Encora Ltd | Administrative & support | 2017 |
| Encore Holdings Ltd | Real estate | 2023 |
| Encore Tavistock Ltd | Construction | 2023 |
| Endeavour Property Development Limited | Professional & scientific | 2014 |
| Endeavour R2 Ltd | Wholesale & retail | 2023 |
| Endeavour Retail Ltd | Wholesale & retail | 2022 |
| Endeavour Solutions Limited | Professional & scientific | 2008 |
| Enderwade Flat Management Limited | Households | 1991 |
| Endocrine Iasis Limited | Health & social care | 2022 |
| Endomishra Limited | Health & social care | 2017 |
| Endorsed Media Limited | Information & communication | 2019 |
| Enduro Construction Limited | Construction | 2008 |
| Endymion Research Ltd | Information & communication | 2024 |
| Energoinvest Reach Active (UK) Limited | Construction | 2013 |
| Energy Design Studio Limited | Professional & scientific | 1999 |
| Energy Esprit Limited | Other services | 2014 |
| Energy Essentials Co Ltd | Administrative & support | 2023 |
| Energy Move Limited | Construction | 2013 |
| Energyw!Se Ltd | Professional & scientific | 2022 |
| Engaged Business Consultants Limited | Professional & scientific | 2021 |
| Engine Masters LP Ltd | Wholesale & retail | 2025 |
| Engine Medics Ltd | Wholesale & retail | 2024 |
| Engineer Consultancy Limited | Professional & scientific | 2015 |
| Engineering Consulting Project Limited | Administrative & support | 2017 |
| Engineworks AI Ltd | Information & communication | 2026 |
| Englefield Property Developments Ltd | Construction | 2025 |
| Engorecords Ltd | Information & communication | 2020 |
| Enhance Office Cleaning Limited | Administrative & support | 2010 |
| Enhanced Labs UK Limited | Wholesale & retail | 2021 |
| Enhancing Potential Ltd | Administrative & support | 2010 |
| Eniac Systems PVT Ltd | Information & communication | 2026 |
| Enigma Talent Ltd | Arts & recreation | 2020 |
| Enigmatic Smile Ltd | Information & communication | 2014 |
| Enjoy Health Limited | Health & social care | 2020 |
| Enjoy Property Limited | Real estate | 2023 |
| ENK Solutions Limited | Administrative & support | 2011 |
| Enkii Ltd | Construction | 2023 |
| Enlighten Properties Ltd | Real estate | 2015 |
| Enlighten Supply Pool Ltd | Administrative & support | 2010 |
| Enlightenment Films Ltd | Information & communication | 2004 |
| ENN Care & Support Ltd | Health & social care | 2023 |
| Enniscorthy Bars Ltd | Hospitality | 2017 |
| Ennismore Fine Art Limited | Other services | 2014 |
| Enova Enterprise Limited | Wholesale & retail | 2026 |
| Enovise Limited | Information & communication | 2022 |
| Enrich Agency Ltd | Information & communication | 2023 |
| Ensemblier Limited | Professional & scientific | 2012 |
| Ensoftwarment Limited | Administrative & support | 2013 |
| ENT Surgeon Limited | Health & social care | 2023 |
| Entelia Technologies Limited | Information & communication | 2018 |
| Enter Pages Pro Ltd | Information & communication | 2015 |
| Enterprise Investment Systems Ltd | Professional & scientific | 2017 |
| Enterprise System Solutions Limited | Information & communication | 2013 |
| Enterprise UN. Ltd | Administrative & support | 2007 |
| Enterprise Wellness Ltd | Administrative & support | 1983 |
| Entervision Intercom Limited | Administrative & support | 1994 |
| Enthew Productions Limited | Information & communication | 2015 |
| Enthusis Limited | Information & communication | 1999 |
| Entire Fire Safety Ltd | Manufacturing | 2025 |
| Entre Properties Ltd | Real estate | 2024 |
| Entree 2008 Ltd | Hospitality | 2019 |
| Entwined Productions Ltd | Other services | 2017 |
| Enuix Limited | Information & communication | 2018 |
| Envecta Limited | Information & communication | 2002 |
| Enviro Friendly Homes Ltd | Construction | 2021 |
| Enviroclean (Services) Limited | Administrative & support | 1990 |
| Envision Courses Limited | Education | 2022 |
| Envision RR 1 Ltd | Financial services | 2024 |
| Envision RR 2 Ltd | Financial services | 2023 |
| Envision RR 3 Ltd | Financial services | 2024 |
| Envision RR Ltd | Financial services | 2023 |
| Enxoo AI Hub Ltd | Information & communication | 2022 |
| Enyji Limited | Wholesale & retail | 2011 |
| Enzed Ltd | Information & communication | 1996 |
| Enzo Properties Limited | Construction | 2009 |
| Enzymex Limited | Professional & scientific | 2020 |
| EO Kitchens Ltd | Professional & scientific | 2023 |
| Eoghan Construction Services Limited | Professional & scientific | 2016 |
| EOM Properties Limited | Real estate | 2016 |
| EOS Recruitment RG Limited | Administrative & support | 2017 |
| Epex Software Engineering UK Ltd | Professional & scientific | 2025 |
| EPH Controls Limited | Wholesale & retail | 2010 |
| Epic Oak Limited | Education | 2016 |
| Epicurean Haven London Ltd | Hospitality | 2025 |
| Epogy Ltd | Financial services | 2026 |
| Epok Agency Limited | Professional & scientific | 2012 |
| Eprocess Limited | Extraterritorial | 2020 |
| Eprocessor Accountants Ltd | Extraterritorial | 2019 |
| Eprocessor Tax Advisors Ltd | Professional & scientific | 2015 |
| Eprotec Limited | Information & communication | 2014 |
| Epsd LLP | | 2018 |
| Epsilon Consultancy Limited | Information & communication | 2019 |
| Epsilon Property Associates Ltd | Real estate | 2014 |
| Eqaa Designs Ltd | Construction | 2023 |