| Stratford Road UB4 Limited | Administrative & support | 2026 |
| Strathearn Publishing Limited | Information & communication | 1912 |
| Stratnova Consulting Limited | Administrative & support | 2025 |
| Stratosvale Limited | Wholesale & retail | 2025 |
| Stratxion Limited | Professional & scientific | 2019 |
| Streamline Films Ltd | Information & communication | 2026 |
| Street Aviation Services Limited | Transport & logistics | 2016 |
| Street Bitez Ltd | Wholesale & retail | 2023 |
| Streetlite Limited | Wholesale & retail | 2021 |
| Streets Digital Limited | Wholesale & retail | 2015 |
| Strelitzia Limited | Other services | 2006 |
| Stretching Boundaries Ltd | Professional & scientific | 2015 |
| Stretford Home Limited | Health & social care | 2024 |
| Strike Sports Ltd | Wholesale & retail | 2018 |
| Stringnote Limited | Education | 2014 |
| Strive and Succeed Ltd | Health & social care | 2020 |
| Strive Development Limited | Information & communication | 2013 |
| Strive Global Talent Limited | Professional & scientific | 2020 |
| Strong and Turton Limited | Wholesale & retail | 1962 |
| Strong Language Limited | Professional & scientific | 2001 |
| Strong Management Solutions Limited | Professional & scientific | 2005 |
| Structa Roofing Limited | Construction | 2021 |
| Structshape Limited | Manufacturing | 2025 |
| Structural Developments and Innovations Limited | Professional & scientific | 2012 |
| Structure Line Ltd | Construction | 2025 |
| Structures Consult and Construction Ltd | Professional & scientific | 2022 |
| Stryger Investments Ltd. | Wholesale & retail | 2024 |
| STU the Pharma Ltd | Wholesale & retail | 2020 |
| Stubby Leas Care Home Ltd | Health & social care | 2023 |
| Stucco Construction Ltd | Construction | 2017 |
| Student Comfort Ltd | Wholesale & retail | 2020 |
| Student Vault Management Ltd | Construction | 2018 |
| Studenttemp Limited | Extraterritorial | 2007 |
| Studio 5 (London) Design Limited | Professional & scientific | 2020 |
| Studio 88 Limited | Arts & recreation | 1963 |
| Studio Belta Ltd | Professional & scientific | 2016 |
| Studio Blackdown Limited | Professional & scientific | 2025 |
| Studio Hundreds Ltd | Construction | 2011 |
| Studio Magic Films Ltd | Information & communication | 2021 |
| Studio SC Limited | Professional & scientific | 2025 |
| Studio Sinders Limited | Professional & scientific | 2021 |
| Studio SS Limited | Arts & recreation | 2023 |
| STUDIO9 Architects Ltd | Professional & scientific | 2026 |
| Study Direct Ltd | Education | 2025 |
| Study in England Ltd | Education | 2023 |
| Study With US Ltd | Education | 2026 |
| Studyglobe Limited | Professional & scientific | 2020 |
| Studyuniv Limited | Education | 2017 |
| Stuhoo Ltd | Wholesale & retail | 2020 |
| Stunning Blooms Ltd | Wholesale & retail | 2024 |
| STX Finance UK Limited | Administrative & support | 2018 |
| Style 4 U Limited | Wholesale & retail | 1999 |
| Style N Smile Ltd | Other services | 2018 |
| Style N' Decore Ltd | Other services | 2019 |
| Style Property Letting Limited | Real estate | 2025 |
| Style-On Ltd | Wholesale & retail | 2018 |
| Styled by Smita Ltd | Other services | 2024 |
| Stylenish Ltd | Other services | 2017 |
| Stylish Brow & Beauty Ltd | Other services | 2020 |
| Stylish Fabrics (London) Ltd | Wholesale & retail | 2016 |
| Stylo Signs Ltd | Professional & scientific | 2018 |
| Stylo Worldwide Limited | Administrative & support | 2011 |
| SU1 Drylining Ltd | Construction | 2024 |
| Suavaé Ltd | Wholesale & retail | 2020 |
| Suave Concepts Limited | Wholesale & retail | 2018 |
| Subara Business Network Ltd | Administrative & support | 2023 |
| Subaran IT Consultancy Limited | Information & communication | 2015 |
| Subbie Street Caterers Ltd | Hospitality | 2019 |
| Subcontinental Supplies Ltd | Professional & scientific | 2024 |
| Subcore Scaffolding Ltd | Construction | 2025 |
| Subex (UK) Limited | Information & communication | 2001 |
| Subhida UK Ltd | Wholesale & retail | 2007 |
| Subi & Bevin Limited | Wholesale & retail | 2024 |
| Sublime R&M Ltd | Real estate | 2024 |
| Submitontime Ltd | Administrative & support | 2025 |
| Subramaniam Skanthatheva Ltd | Extraterritorial | 2024 |
| Subsa Investments Ltd | Real estate | 2018 |
| Subtechnology Ltd | Other services | 2025 |
| Subvick Limited | Wholesale & retail | 1987 |
| Successive Property Limited | Real estate | 2017 |
| Suceava Grocery Ltd | Wholesale & retail | 2019 |
| Suchak Investments Limited | Real estate | 2014 |
| Sudais Limited | Construction | 2015 |
| Sudbury Court Limited | Wholesale & retail | 2010 |
| Sudbury Food Centre Limited | Hospitality | 2024 |
| Sudbury Hill Drycleaners Limited | Other services | 2025 |
| Sudbury Hill Fisheries Limited | Wholesale & retail | 2026 |
| Sudbury Hills Close Limited | Construction | 2018 |
| Sudbury Market Ltd | Wholesale & retail | 2026 |
| Sudshi IT Limited | Wholesale & retail | 2024 |
| Sudshi Limited | Hospitality | 2022 |
| Sudshi Trading Co Limited | Wholesale & retail | 2024 |
| SUE Bicknell Design Limited | Arts & recreation | 2017 |
| Sueno-Co UK Ltd | Professional & scientific | 2023 |
| Sufair Ltd | Professional & scientific | 2019 |
| Sufee Limited | Wholesale & retail | 2025 |
| Suffolk Family Ltd | Extraterritorial | 2024 |
| Sufra Links Ltd | Professional & scientific | 2025 |
| Sufro (Investments) Limited | Construction | 1989 |
| Sugantham Food Ltd | Wholesale & retail | 2019 |