| Elpis Holdings Limited | Financial services | 2019 |
| Elpis Management Limited | Financial services | 2019 |
| ELS Site Services Ltd | Professional & scientific | 2023 |
| Elumie Ltd | Wholesale & retail | 2024 |
| ELV1S Ltd | Extraterritorial | 2018 |
| Elvario for Trade Ltd | Wholesale & retail | 2024 |
| Elvins Estate Agents Ltd | Real estate | 2020 |
| ELY Trading Limited | Professional & scientific | 2021 |
| Elysian Harrogate Ltd | Hospitality | 2024 |
| Elysium Developments (UK) Ltd | Construction | 2007 |
| EM Recruiting Limited | Administrative & support | 2016 |
| Emaar Tolin Ltd | Construction | 2022 |
| Ember Design Limited | Information & communication | 2013 |
| Embracing Future Potential Ltd | Information & communication | 2020 |
| EMC Event Structures Ltd | Other services | 1996 |
| EMD UK C.I.C. | Education | 2009 |
| Emendo Solutions Ltd | Information & communication | 2018 |
| Emerging Power Consultants Ltd | Professional & scientific | 2022 |
| Emheda Consulting Limited | Professional & scientific | 2024 |
| Emheda Limited | Real estate | 2016 |
| Emheda Property Ltd | Other services | 2023 |
| EMIL1A Limited | Extraterritorial | 2020 |
| Emin Associates Ltd | Professional & scientific | 2023 |
| Eminka Ltd | Professional & scientific | 2019 |
| Emma & Robert Properties Ltd | Real estate | 2022 |
| Emma Cook Ltd | Health & social care | 2023 |
| Emma Mellor Handmade Rugs Ltd | Wholesale & retail | 2017 |
| Emoc Ltd | Extraterritorial | 2012 |
| Emol Limited | Financial services | 1997 |
| Empower Harrogate Limited | Arts & recreation | 2025 |
| Empowered Living Ltd | Health & social care | 2014 |
| Empowerup Solutions Ltd | Professional & scientific | 2025 |
| Emsley Brothers Limited | Professional & scientific | 2003 |
| Emsley Crane Hire Limited | Construction | 1979 |
| Enchanticas Limited | Arts & recreation | 2022 |
| Endur Properties Limited | Construction | 2024 |
| Endymion Legal Services Limited | Professional & scientific | 2018 |
| Energize Fitness Ltd | Arts & recreation | 2020 |
| Energy From the Sun Limited | Extraterritorial | 2011 |
| Energy MT Ltd | Wholesale & retail | 2024 |
| Energy Oasis Limited | Professional & scientific | 2013 |
| Energy Warriors Limited | Energy | 2015 |
| Enforce Parking Management Services Limited | Transport & logistics | 2025 |
| Engage Change Ltd | Information & communication | 2023 |
| Engage Four Limited | Administrative & support | 2022 |
| Engage Innovation Ltd | Information & communication | 2011 |
| Engage SIX Limited | Administrative & support | 2023 |
| Engage Three Limited | Administrative & support | 2022 |
| Engage Two Limited | Administrative & support | 2021 |
| Enid Taylor Limited | Manufacturing | 1956 |
| Enigma Network Ltd | Other services | 2025 |
| Enjoy Tefl Limited | Education | 2015 |
| Enjoy the Fruit Limited | Hospitality | 2016 |
| Enjoyment Limited | Extraterritorial | 2012 |
| Enoch Traders Limited | Wholesale & retail | 2023 |
| Enquire Within Associates Ltd | Health & social care | 2013 |
| Entaview Creative Ltd | Information & communication | 2024 |
| Entech Commercial Group Limited | Energy | 2015 |
| Entech Commercial Limited | Professional & scientific | 1991 |
| Enterprise Global Services Ltd | Wholesale & retail | 2024 |
| Entertaining Retail Ltd | Professional & scientific | 2017 |
| Entertainment Services (Northern) Ltd | Arts & recreation | 2009 |
| Envirocareer Limited | Administrative & support | 2024 |
| Environmental & Engineering Group Limited | Financial services | 2023 |
| Envirophone Limited | Extraterritorial | 2011 |
| Envirovent Franchising Limited | Other services | 2025 |
| Envirovent Limited | Manufacturing | 2007 |
| EO Green Utilities Ltd | Energy | 2021 |
| EOT Limited | Real estate | 2022 |
| EP Print Limited | Manufacturing | 2018 |
| EP1C Limited | Wholesale & retail | 2021 |
| EPH Communications Ltd | Information & communication | 2024 |
| Epic Solutions (BE) Ltd | Construction | 2024 |
| Epicurien Ltd | Hospitality | 2019 |
| Epimonis Ltd | Professional & scientific | 2025 |
| Epione Aesthetics Ltd | Health & social care | 2021 |
| Epsom Court (LW) Management Company Limited | Households | 2017 |
| Equanimity Group Ltd | Financial services | 2023 |
| Equity SQ Limited | Professional & scientific | 2014 |
| Equity SQ Wealth Limited | Professional & scientific | 2023 |
| ER1C Ltd | Extraterritorial | 2018 |
| ERA Harrogate Limited | Other services | 2025 |
| Ergotherapy Ltd | Health & social care | 2017 |
| Erhc Services Limited | Professional & scientific | 2023 |
| Erised Limited | Professional & scientific | 2006 |
| Esale (UK) Limited | Real estate | 2010 |
| Escapade Film Ltd | Information & communication | 2011 |
| Esend Ltd | Information & communication | 2018 |
| ESG Investments Limited | Real estate | 2024 |
| ESK Hall Limited | Health & social care | 2005 |
| Esme Holdings Limited | Hospitality | 2025 |
| Esplanade Flats (Harrogate) Limited | Households | 1975 |
| Essencevale Limited | Real estate | 1998 |
| Essential Consulting Limited | Education | 2020 |
| Essential FM Limited | Extraterritorial | 2025 |
| Essential Talent Ltd | Administrative & support | 2025 |
| Essential Therapeutics Harrogate Ltd | Health & social care | 2021 |
| Essentials of Huby Limited | Wholesale & retail | 2001 |
| Estarfolio Ltd | Real estate | 2025 |
| Estate Consultations Limited | Real estate | 2017 |