| Dean Farm Developments Limited | Real estate | 2021 |
| Dean Heim & Company Limited | Professional & scientific | 2024 |
| DEBB1E Limited | Extraterritorial | 2020 |
| DEDICATED7 Limited | Information & communication | 2023 |
| Deedy Assist Limited | Administrative & support | 2017 |
| Deep Blue Treatments Limited | Health & social care | 2006 |
| Deep Focus Productions Limited | Information & communication | 2009 |
| Deep Freeze Limited | Extraterritorial | 2012 |
| Deer Glade Court Management Limited | Households | 2021 |
| Defender Securities Limited | Extraterritorial | 2025 |
| Defenition Limited | Professional & scientific | 2016 |
| Defi Capital Ltd | Information & communication | 2021 |
| DEL1 VER Limited | Other services | 2017 |
| DEL1CIOUS Limited | Wholesale & retail | 2023 |
| Delahope Limited | Financial services | 1934 |
| Delicious Tours and Events Ltd | Hospitality | 2022 |
| Deliciouslyorkshire Limited | Hospitality | 2011 |
| Delight Global Logistics UK Ltd | Transport & logistics | 2016 |
| Delikata Shop Ltd | Manufacturing | 2021 |
| Delivering Alpha Ltd | Financial services | 2023 |
| Delosos Ltd | Hospitality | 2024 |
| Delta Projects (UK) Limited | Construction | 2003 |
| Delves Ridge Limited | Financial services | 2015 |
| Demic Ltd | Extraterritorial | 2012 |
| Dencon Ltd | Water & waste | 2018 |
| Dene Corporation Limited | Extraterritorial | 1991 |
| Dene International Limited | Information & communication | 1996 |
| Dene Support Services Limited | Information & communication | 1995 |
| Denise Smith Limited | Professional & scientific | 2013 |
| DENN1S Limited | Extraterritorial | 2020 |
| Dentally Yours Limited | Health & social care | 2017 |
| Dentozen Harrogate Ltd | Health & social care | 2024 |
| Denwood Consulting Limited | Information & communication | 2023 |
| Desert Sign Trading Ltd | Wholesale & retail | 2024 |
| Design by ANT Ltd | Professional & scientific | 2013 |
| Design Modules Holdings Limited | Financial services | 2019 |
| Design-Tech Limited | Real estate | 1961 |
| Designer Doggies Ltd | Wholesale & retail | 2019 |
| Designer International Limited | Extraterritorial | 2025 |
| Designs by Loulabelle Limited | Manufacturing | 2011 |
| Despot Film Ltd | Information & communication | 2011 |
| Destination Gaming Ltd | Administrative & support | 2023 |
| Destination York Limited | Real estate | 2022 |
| Destiny Afrofoods Restaurant Ltd | Hospitality | 2024 |
| Destructuring-Bind Limited | Information & communication | 2007 |
| Detectronic Holdings Limited | Financial services | 2019 |
| Detectronic Limited | Manufacturing | 2007 |
| Deter Limited | Extraterritorial | 2012 |
| Determination Innovation and Production Limited | Information & communication | 2022 |
| Deutschland Limited | Extraterritorial | 2022 |
| Deuxieme Quatre Limited | Real estate | 2025 |
| Deveer Quarters (Knaresborough) Limited | Construction | 2020 |
| Developed Limited | Wholesale & retail | 2025 |
| Development Sharing (Buildings) Limited | Professional & scientific | 1985 |
| Development Sharing (High Skellgate) Limited | Construction | 1988 |
| Devonshire Bloom Properties Ltd | Real estate | 2025 |
| Devonshire Facilities Limited | Extraterritorial | 2025 |
| Devonshire Mews Properties RTM Company Limited | Households | 2015 |
| Devynock Probate Research Ltd | Financial services | 2003 |
| Dexter Ashgaurd Limited | Extraterritorial | 2026 |
| Dexter Commercial Limited | Wholesale & retail | 2021 |
| Dexxter Limited | Wholesale & retail | 2024 |
| Dfwtl Limited | Arts & recreation | 2018 |
| DGC Property & Rental Limited | Real estate | 2019 |
| DH Land Ltd | Construction | 2017 |
| Diagonal Medical Limited | Administrative & support | 2021 |
| Dial Asset Management (2015) Limited | Professional & scientific | 2015 |
| Dial Asset Management (2016) Limited | Administrative & support | 2016 |
| Dial Asset Management (2025) Ltd | Professional & scientific | 2025 |
| Dial Asset Management Limited | Administrative & support | 2000 |
| Dial House Developments LLP | | 2019 |
| Dial Park LLP | | 2025 |
| Dial Partners LLP | | 2009 |
| Diamond 99 Turkish Barber Ltd | Other services | 2025 |
| Diamond Home Lettings Limited | Real estate | 2013 |
| Diamond Sea Limited | Real estate | 2023 |
| Diamonds 2 Your Door Ltd | Wholesale & retail | 2025 |
| Diamonte Jets Limited | Transport & logistics | 2015 |
| Dickinson Developments Limited | Construction | 2024 |
| Dickinson School Consulting Limited | Education | 2009 |
| Different Minds Yorkshire Ltd | Health & social care | 2025 |
| Different PR Limited | Professional & scientific | 2005 |
| Digiblocks Ltd | Information & communication | 2024 |
| Digital Emotion Ltd | Professional & scientific | 1997 |
| Digital One Web Design & Development Limited | Other services | 2011 |
| Digital Protection Limited | Extraterritorial | 2026 |
| Digital Shift Marketing Ltd | Information & communication | 2021 |
| Dignus Floors Limited | Construction | 2025 |
| Dilligas Distribution Ltd | Wholesale & retail | 2014 |
| Dimension Products Ltd | Wholesale & retail | 2023 |
| Diminuere Ltd | Public administration | 2024 |
| Dimitra Ltd | Real estate | 2025 |
| Direct Business Advice Limited | Professional & scientific | 2002 |
| Direct Storage Solutions Limited | Wholesale & retail | 2022 |
| Directai Limited | Information & communication | 2023 |
| Directions Planning Consultancy Limited | Professional & scientific | 2010 |
| Direx Solutions Ltd. | Professional & scientific | 2001 |
| Dirty Media Limited | Extraterritorial | 2026 |
| Dishang Cherry Limited | Manufacturing | 2005 |
| Dishang Trading Limited | Administrative & support | 2011 |