| Rothamsted Scientific Services Limited | Professional & scientific | 2022 |
| Roundwood Park School Academy Trust | Education | 2011 |
| Roxhill Media Limited | Information & communication | 2013 |
| Rozh Production Limited | Hospitality | 2025 |
| RP Novo Construction Limited | Construction | 2014 |
| RPJ Accountancy Ltd | Professional & scientific | 2007 |
| RPS Associates Ltd. | Professional & scientific | 1997 |
| RS Trades Leeds Ltd | Wholesale & retail | 2024 |
| RT60 Ltd | Information & communication | 2019 |
| RTD Financial Services Ltd | Administrative & support | 2016 |
| Rubiks Limited | Real estate | 2021 |
| Rumball Sedgwick Limited | Other services | 2014 |
| Rumball Sedgwick Surveying Limited | Professional & scientific | 2021 |
| Rush Music Limited | Information & communication | 2010 |
| Rushbrooke Services Limited | Health & social care | 2025 |
| Rushton Consulting Limited | Professional & scientific | 2008 |
| Russian Ice Stars Limited | Arts & recreation | 1995 |
| Rycote Leisure Ltd | Wholesale & retail | 2020 |
| S & G Home and Leisure Ltd | Information & communication | 2013 |
| S Bish Estate Planning Ltd | Professional & scientific | 2023 |
| S Harrison Purchasing Ltd | Administrative & support | 2023 |
| S J Hill Consulting Ltd | Information & communication | 2026 |
| S Lipscomb Property Limited | Real estate | 2020 |
| S&A Stunning Homes Ltd | Construction | 2022 |
| S. J. Burrell Limited | Health & social care | 2010 |
| S. Sarkar Limited | Health & social care | 2013 |
| S.Culmer Consulting Ltd | Public administration | 2019 |
| S.I.M.C Trading Limited | Wholesale & retail | 2025 |
| S4RG Ltd | Information & communication | 2020 |
| Saadi Gymnastics Ltd | Education | 2017 |
| Saar Solutions Ltd | Information & communication | 2018 |
| Sabelhold Flat Management Company Limited | Households | 1978 |
| Sabin Limited | Professional & scientific | 2014 |
| Sachelle Interior Designs Limited | Construction | 1980 |
| Safe Flight Limited | Professional & scientific | 2022 |
| Sail Consultancy Limited | Professional & scientific | 2018 |
| SAM Mackney SPV1 Ltd | Real estate | 2025 |
| SAN Holdings Limited | Professional & scientific | 2017 |
| Sandpit Management Company Limited | Households | 1981 |
| Sandtoft Flat Management Company Limited | Households | 1981 |
| Santolina Services Ltd | Professional & scientific | 2025 |
| Sapience IT Limited | Information & communication | 2016 |
| Saptha Kannigal Properties Limited | Real estate | 2021 |
| Sarah Bundock Ltd | Wholesale & retail | 2019 |
| Sarah L Richardson Limited | Professional & scientific | 2007 |
| Sarah Murfitt Consulting Limited | Professional & scientific | 2015 |
| Sarah Pritchard Design Limited | Professional & scientific | 2021 |
| Sarah Pritchard Limited | Professional & scientific | 2020 |
| Sarikaya Plumbing and Heating Ltd | Construction | 2021 |
| Sarisin Export & Import Consultancy Ltd | Wholesale & retail | 2020 |
| Sarlas Racing Team Limited | Arts & recreation | 2023 |
| Satori Motorworks Ltd | Wholesale & retail | 2023 |
| Satori PPF Riverside Ltd | Wholesale & retail | 2024 |
| Satori Storage Riverside Ltd | Wholesale & retail | 2024 |
| Sauce Consultancy Limited | Other services | 2018 |
| Sauncey Avenue Property Limited | Administrative & support | 2009 |
| Savvy One Limited | Professional & scientific | 2025 |
| Savytech Limited | Hospitality | 2009 |
| SB Infotech Ltd | Information & communication | 2026 |
| SBP Management and Engineering Solutions Ltd. | Construction | 2016 |
| SBP Property Development Ltd | Real estate | 2021 |
| SC Events Marketing Limited | Hospitality | 2022 |
| Scaffolding Prestige Limited | Construction | 2023 |
| Scandia Foods (UK) Limited | Wholesale & retail | 1988 |
| Scandic Foods Limited | Wholesale & retail | 1999 |
| Scarlett’S Kitchen Limited | Hospitality | 2026 |
| SCG Software Ltd | Information & communication | 2013 |
| Schurkee Ltd | Manufacturing | 2024 |
| Scrabo Holdings Limited | Professional & scientific | 2016 |
| Scully Physio Ltd | Health & social care | 2026 |
| Sculpt Academy Limited | Other services | 2023 |
| SD Shopfitting Contracts Limited | Construction | 2003 |
| SDH Quality Properties Ltd | Real estate | 2023 |
| Season Change Ltd | Hospitality | 2024 |
| Sebastian Morgan Limited | Professional & scientific | 1999 |
| SEC Consulting Services Ltd | Professional & scientific | 2025 |
| Second Chiltern Park (Management) Limited | Households | 1976 |
| Second Mind Systems Ltd | Information & communication | 2025 |
| Secondhalf Limited | Wholesale & retail | 2018 |
| Secura Solutions Limited | Administrative & support | 2023 |
| Sedgewick Flat Management Company Limited | Households | 1983 |
| Seekers Games Limited | Manufacturing | 2018 |
| Selectus Property Limited | Other services | 2011 |
| Selva Consulting Services Limited | Professional & scientific | 2018 |
| SEN Gurung Ltd | Wholesale & retail | 2021 |
| Sensible Care Limited | Extraterritorial | 2012 |
| Sentavision Limited | Professional & scientific | 2021 |
| Sentinel Advanced Security Services Ltd | Administrative & support | 2025 |
| Seomra Design Limited | Professional & scientific | 2020 |
| SEP Property Investment Ltd | Real estate | 2017 |
| Seren Wealth Ltd | Financial services | 2025 |
| Serenity Supported Living Services Ltd | Health & social care | 2023 |
| Service to Others Ltd | Other services | 2019 |
| Sexton Financial Services Limited | Financial services | 2016 |
| SFH Event Partners Limited | Hospitality | 2025 |
| SG Realty Limited | Real estate | 2022 |
| SGM Renewables Ltd | Construction | 2022 |
| Shafford Boutique Accommodation Ltd | Hospitality | 2022 |
| Shah Bain Limited | Real estate | 2021 |
| Shapes First Ltd | Extraterritorial | 2024 |