| Samuelson Shows Limited | Administrative & support | 2016 |
| Samyra Properties Limited | Real estate | 2023 |
| Sanctum Enterprises Ltd | Real estate | 2024 |
| Sandaul Limited | Real estate | 2015 |
| Sanho Consulting Ltd | Hospitality | 2020 |
| Sanho Properties Ltd | Real estate | 2018 |
| Saniloma Properties Limited | Real estate | 2014 |
| Sans-Limit UK Company Ltd | Real estate | 2017 |
| Santosh Capital Limited | Construction | 2021 |
| Sapgrow Ltd | Real estate | 2017 |
| Sara Homes Group Ltd | Construction | 2025 |
| Sarah and Duck Limited | Administrative & support | 2010 |
| Saratoga Consulting Services Limited | Professional & scientific | 2022 |
| Sarian Homes Limited | Real estate | 2017 |
| SAS Capital Limited | Real estate | 2019 |
| Saxon Court (Surbiton) Residents Co. Limited | Households | 1985 |
| Scale Purple Ltd | Professional & scientific | 2025 |
| Scanclub Ltd | Professional & scientific | 2024 |
| SCG London Ltd | Health & social care | 2015 |
| Schandis Limited | Information & communication | 2010 |
| Sciqics Ltd | Information & communication | 2017 |
| Scoop and Waffle Limited | Wholesale & retail | 2021 |
| Scotney (Garages) Limited | Wholesale & retail | 1959 |
| Scotswissdevelopments Ltd | Real estate | 2017 |
| Scullise Communications Limited | Professional & scientific | 2018 |
| Sealrock Limited | Real estate | 2007 |
| Second Chillerton Residents Association (Hampton) Limited | Other services | 1981 |
| Seeca Music Limited | Information & communication | 2004 |
| Sekhon Consulting Limited | Professional & scientific | 2015 |
| Semper Fidelis Ltd | Real estate | 2015 |
| Sentinel Infrastructure Group Ltd | Professional & scientific | 2025 |
| Sequence Financial Limited | Administrative & support | 2023 |
| Seraphis Ltd | Wholesale & retail | 2019 |
| Serendipity Films Ltd | Information & communication | 2015 |
| Seriously Opinionated Ltd | Professional & scientific | 2020 |
| Servco-Uk Ltd | Extraterritorial | 2013 |
| Servicelink Ltd | Wholesale & retail | 2005 |
| Seven Cows Limited | Real estate | 2017 |
| Seventy Seven & Co Group Ltd | Administrative & support | 2026 |
| SF Healthcare Limited | Administrative & support | 2008 |
| Shahid and Nahida Khan Property Investment Limited | Real estate | 2010 |
| Shahmuir Associates Limited | Professional & scientific | 2013 |
| Shamal Desaur Design Consultancy Ltd | Wholesale & retail | 2015 |
| Shan Investment Property Ltd | Real estate | 2025 |
| Shanghai Village (Twickenham) Limited | Real estate | 2007 |
| Shapeshift Solutions Limited | Professional & scientific | 2025 |
| Shared Value Ltd | Professional & scientific | 2011 |
| Sharmella D Ltd | Real estate | 2017 |
| Shaun Knight Architecture Ltd | Professional & scientific | 2011 |
| Shayan Multi-Services Limited | Hospitality | 2011 |
| Shayan VIP Limited | Transport & logistics | 2019 |
| Sheen Gardening Co Limited | Administrative & support | 2015 |
| Sheengate Holdings Limited | Information & communication | 2020 |
| Sheengate Publishing Limited | Information & communication | 1998 |
| Sherborne in the Community | Real estate | 1993 |
| Sheridan Place Management Company Limited | Real estate | 1984 |
| Shew Limited | Professional & scientific | 2010 |
| Sheza Investment Ltd | Real estate | 2016 |
| Shickle Limited | Professional & scientific | 2008 |
| Shikra London Ltd | Wholesale & retail | 2023 |
| Shooterk UK Limited | Wholesale & retail | 2012 |
| Shooting Star Children's Hospices | Health & social care | 1994 |
| Shooting Star Marketing Limited | Wholesale & retail | 1995 |
| Shorewoods Developments Limited | Construction | 2007 |
| Show ME My Tech Limited | Information & communication | 2021 |
| Shree Ganesh Enterprises Ltd | Professional & scientific | 2022 |
| SHU Ventures Ltd | Real estate | 2016 |
| SIA Technology Asia Limited | Information & communication | 2014 |
| Sigma Financial Consulting Limited | Professional & scientific | 2024 |
| Sigor Limited | Professional & scientific | 2019 |
| Silly Incorporated Ltd | Information & communication | 2026 |
| Silver Drum Limited | Administrative & support | 2013 |
| Silver Stallion Services Limited | Wholesale & retail | 2025 |
| Silvercube Media Group Ltd | Education | 2016 |
| Silverstone Autos Ltd | Wholesale & retail | 2026 |
| Simon Humphries Ltd | Professional & scientific | 2011 |
| Simon Jones Transport Limited | Transport & logistics | 2021 |
| Simon Stockton Associates Ltd | Health & social care | 2019 |
| Simply Done Removals Ltd | Transport & logistics | 2023 |
| Sims Systems Limited | Manufacturing | 1993 |
| Sing Sing Properties Ltd | Real estate | 2018 |
| Singer Property Portfolio Ltd | Construction | 2024 |
| Singh Fudge Limited | Professional & scientific | 2021 |
| Singh Invest Ltd | Wholesale & retail | 2020 |
| Sinnovia Ltd | Professional & scientific | 2025 |
| Sjrw Osteopathy Ltd | Health & social care | 2011 |
| SK Sports Management PVT Ltd | Wholesale & retail | 2017 |
| SKE UK Distribution Ltd | Wholesale & retail | 2025 |
| SKN Horizons Ltd | Real estate | 2019 |
| SKN Skyline Ltd | Real estate | 2023 |
| Skyfield Logistics Limited | Transport & logistics | 2026 |
| Skypulse Property Ltd | Extraterritorial | 2017 |
| SL Associates Inc. Limited | Professional & scientific | 2017 |
| SL Locations Ltd | Real estate | 2025 |
| Slan Property Investments Ltd | Real estate | 2017 |
| SLD Consultancy Services Limited | Professional & scientific | 2026 |
| Sloggett Group Limited | Professional & scientific | 1988 |
| SM Ladybug Ltd | Arts & recreation | 2026 |
| SM Live Ltd | Information & communication | 2026 |
| Smart Figures Limited | Professional & scientific | 2014 |