| Driveluxe Ltd | Wholesale & retail | 2021 |
| Driver Force Hire Ltd | Transport & logistics | 2016 |
| DRO Detailing Ltd | Wholesale & retail | 2020 |
| DRS Intervention Ltd | Health & social care | 2023 |
| Druggitt & Harding Limited | Construction | 2008 |
| Druk Limited | Professional & scientific | 2007 |
| Drummond Embroidery Limited | Wholesale & retail | 2024 |
| Drystone Radio Limited | Information & communication | 1998 |
| Drytino Limited | Wholesale & retail | 2023 |
| DS Building Systems Ltd | Construction | 2006 |
| DS Developing Limited | Real estate | 2003 |
| DS Security (Yorkshire) Ltd | Administrative & support | 2024 |
| DS2 Holdings Limited | Financial services | 2023 |
| Dsdodd Limited | Construction | 2023 |
| DST Holdings Ltd | Wholesale & retail | 2013 |
| DT Building and Groundworks Ltd | Construction | 2021 |
| DT Enterprise Solutions Limited | Professional & scientific | 2019 |
| DT Smiles Ltd | Health & social care | 2011 |
| DT Software Services Ltd | Information & communication | 2015 |
| DTH Joinery Limited | Construction | 2013 |
| DTH Media Limited | Professional & scientific | 2018 |
| Ducati Mondo Limited | Wholesale & retail | 2011 |
| Dudu-Vlm Enterprise Ltd | Health & social care | 2014 |
| Duffy Retaining Solutions Ltd | Construction | 2024 |
| Dugdale Compounds Limited | Manufacturing | 2013 |
| Dundee Farm Livery & Cattery Ltd | Agriculture & fishing | 2023 |
| Dunkirk Service & Maintenance Ltd | Other services | 2025 |
| Dunluce Chepstow Ltd | Wholesale & retail | 2025 |
| Dunston Daynes Ltd | Wholesale & retail | 2025 |
| Dutch Murphy Properties Limited | Real estate | 2025 |
| DV Group Holdings Limited | Financial services | 2025 |
| DV Media Ltd | Professional & scientific | 2024 |
| Dvrt Events Ltd | Hospitality | 2024 |
| DW NW Ltd | Real estate | 2025 |
| DWA Commercial Limited | Professional & scientific | 2020 |
| DWA Queensbury Ltd | Other services | 2017 |
| DX Clothing Limited | Wholesale & retail | 2017 |
| Dynamic Corp Limited | Real estate | 2020 |
| Dynamic Fragrance Corporation Ltd | Manufacturing | 2025 |
| Dynamic Motor Co. Ltd | Wholesale & retail | 2017 |
| Dynamic Shifts Group Ltd | Wholesale & retail | 2025 |
| Dyson Manufacturing Limited | Manufacturing | 2013 |
| E & H Developments Ltd | Real estate | 2024 |
| E Bulmer & Sons Limited | Manufacturing | 2010 |
| E H Oral Hygiene Limited | Health & social care | 2002 |
| E Harris & Sons Ltd | Wholesale & retail | 2019 |
| E Holden Counselling Ltd | Administrative & support | 2022 |
| E Jacobs Designs Limited | Professional & scientific | 2022 |
| E Jacobs Photography Ltd | Professional & scientific | 2018 |
| E K Styling Limited | Manufacturing | 2023 |
| E R Moore (Halifax) Ltd | Other services | 2015 |
| E Vision Halifax Ltd | Construction | 2022 |
| E. & C. Holden Limited | Hospitality | 1977 |
| E.Helliwell Limited | Extraterritorial | 1927 |
| E.R.T Access Ltd | Construction | 2024 |
| E2E SC Consulting Delivered Ltd | Professional & scientific | 2016 |
| E5 Property Limited | Hospitality | 2021 |
| EA Kicks Ltd | Wholesale & retail | 2025 |
| Eagerlux Limited | Real estate | 1987 |
| Eagle House Limited | Construction | 2019 |
| Eagleberg Properties Limited | Real estate | 2021 |
| Earthfit Ltd | Education | 2024 |
| Earthora Ltd | Wholesale & retail | 2025 |
| Earthworks Grab & Haulage Ltd | Water & waste | 2025 |
| Ease-E-Comfort Ltd | Wholesale & retail | 2024 |
| Easibuild Group Ltd | Construction | 2020 |
| East Corner Ltd | Wholesale & retail | 2021 |
| East West Catering Limited | Manufacturing | 2013 |
| Eastern Pride Store Limited | Wholesale & retail | 2022 |
| Eastlena Limited | Wholesale & retail | 2023 |
| Easy Car Park Limited | Administrative & support | 2024 |
| Easy Healthcare (Yorkshire) Limited | Administrative & support | 2021 |
| Easy Select Ltd | Wholesale & retail | 2026 |
| Easysearch Recruitment Ltd | Administrative & support | 2022 |
| EAT Halal Limited | Hospitality | 2020 |
| EAT Smart Move More Fitness and Nutrition Limited | Arts & recreation | 2025 |
| Ebcsa Facilities Limited | Arts & recreation | 2024 |
| Echanorge Enterprises Ltd | Wholesale & retail | 2025 |
| Echoscale Marketing Ltd | Professional & scientific | 2026 |
| Echotree Ltd | Administrative & support | 2015 |
| ECI Technical Services Limited | Construction | 2016 |
| Eckersley Properties Limited | Financial services | 2026 |
| Eclectrick Ltd | Information & communication | 2015 |
| Eclipse Climbing Limited | Wholesale & retail | 2013 |
| Eclipse Energy (Renewables) Limited | Construction | 2021 |
| Eclipse Energy Commercial Renewables Ltd | Construction | 2022 |
| Eclipse Renewables Ltd | Construction | 2024 |
| ECM Installations Limited | Construction | 2016 |
| Eco Affinity Limited | Information & communication | 2021 |
| Eco Paving Solutions Ltd | Construction | 2017 |
| Eco Retrofit Services Ltd | Construction | 2022 |
| Eco Therm (Yorkshire) Ltd | Construction | 2014 |
| Eco Upgrades Halifax Ltd | Professional & scientific | 2024 |
| Eco Windows (Northern) Limited | Manufacturing | 2008 |
| Eco-Lux Solutions Ltd. | Energy | 2015 |
| Ecobright Electrical Solutions Ltd | Energy | 2016 |
| Ecoflow Mechanical Ltd | Construction | 2019 |
| Ecolag Limited | Construction | 2016 |
| Ecoskim Ltd | Construction | 2024 |
| Ecosoils Ltd | Professional & scientific | 2024 |