| Somers Steelstock Limited | Professional & scientific | 1951 |
| Sona Trading Limited | Transport & logistics | 2007 |
| Sophie BEA 17 Ltd | Wholesale & retail | 2025 |
| Sophie BEA 2021 Ltd | Wholesale & retail | 2021 |
| Sophora Estates Limited | Households | 2023 |
| Sosbg Ltd | Construction | 2020 |
| Soul Inah Bowl Ltd | Hospitality | 2019 |
| South Holt Farm Limited | Agriculture & fishing | 2019 |
| South Midlands Trading Limited | Wholesale & retail | 2025 |
| South West Childcare Services Ltd | Health & social care | 2014 |
| Southern Adolescent Care Services Ltd | Other services | 2009 |
| Sovereign Business Solutions Group Limited | Wholesale & retail | 1982 |
| Space Valley Ltd | Wholesale & retail | 2020 |
| Spanner Monkeyz Holdings Ltd | Wholesale & retail | 2017 |
| Spark Vibe Ltd | Administrative & support | 2026 |
| Sparkhill Foods Limited | Wholesale & retail | 2017 |
| SPD UK Services Ltd | Transport & logistics | 2025 |
| Specialised Community Services Limited | Health & social care | 2015 |
| Specsco Limited | Wholesale & retail | 2018 |
| Spector Welding Limited | Wholesale & retail | 2011 |
| Spectrum Independence Care Limited | Health & social care | 2015 |
| Speedshop Productions Limited | Information & communication | 2021 |
| Spencer Signs (UK) Limited | Manufacturing | 2001 |
| Spexmaniax Limited | Wholesale & retail | 2010 |
| Spire Landlord Solutions Limited | Financial services | 2017 |
| Spitfire Paddy the Movie Limited | Information & communication | 2022 |
| Spitfire Projects Limited | Administrative & support | 2003 |
| Sporting Protection Ltd | Manufacturing | 2023 |
| SPP Property Developments Limited | Real estate | 2014 |
| Sprintoval 2005 Limited | Real estate | 2005 |
| Sprintoval Limited | Real estate | 1983 |
| SPS Fitness Ltd | Other services | 2018 |
| SQM Services and Associates Ltd | Wholesale & retail | 2026 |
| SQUAR3D Property Limited | Real estate | 2024 |
| SRH Care Limited | Public administration | 2024 |
| SS Vehicle Recovery Solutions Limited | Transport & logistics | 2025 |
| SSA Land & Lettings Ltd | Construction | 2019 |
| SSE Vehicle Management Limited | Financial services | 2016 |
| Sserv Single PLY Limited | Construction | 2000 |
| ST 2015 Holdings Limited | Real estate | 2015 |
| ST Bridgets Management Company Ltd | Households | 2023 |
| ST Mary's EYE Clinic Limited | Other services | 2011 |
| ST. Eligius Group Limited | Financial services | 2011 |
| Stadium Structures Holdings Limited | Financial services | 2025 |
| Stadium Structures Limited | Construction | 2022 |
| Stage Studios Ltd | Arts & recreation | 2016 |
| Stagnest Limited | Manufacturing | 1984 |
| Stainless Surplus Stocks Limited | Wholesale & retail | 2002 |
| Stair Designs Limited | Manufacturing | 2001 |
| Stamford EYE Consultants Limited | Health & social care | 2021 |
| Stand Grace Services Ltd | Administrative & support | 2018 |
| Standfast Displays Limited | Manufacturing | 2001 |
| Stanley Farm Enterprises LLP | | 2008 |
| Star Courriers Ltd | Transport & logistics | 2020 |
| Star Group (Midlands) Ltd | Transport & logistics | 2015 |
| Star Network Properties Limited | Real estate | 2023 |
| Star Network Retail Limited | Information & communication | 2017 |
| Starshine Hand Car Wash Limited | Wholesale & retail | 2017 |
| Start 2 Finish Couriers Limited | Transport & logistics | 2009 |
| Stead Developments Ltd | Construction | 2020 |
| Steadiworks Limited | Information & communication | 2016 |
| Steam Plant Engineering Limited | Manufacturing | 2001 |
| Stebul Furniture Group Limited | Wholesale & retail | 2021 |
| Steel Security Solutions Limited | Manufacturing | 2014 |
| Steele Force Limited | Administrative & support | 2021 |
| Stefanutto Interactive Ltd | Professional & scientific | 2019 |
| Stelstocks Limited | Wholesale & retail | 1991 |
| Step Toes Dance Limited | Arts & recreation | 2004 |
| Stephen Mullings Limited | Professional & scientific | 2025 |
| Stephenson House Limited | Real estate | 2002 |
| Stepping OUT & About Ltd | Health & social care | 2024 |
| Sterling Ceramics (Dental Laboratory) Limited | Manufacturing | 2004 |
| Sterling HS Limited | Construction | 2025 |
| Sterling Poole Limited | Real estate | 2018 |
| Sterling Redux Holdings Limited | Financial services | 2018 |
| Sterling Redux Ltd | Real estate | 1991 |
| Steve Barratt Limited | Financial services | 2006 |
| Steven ENT Limited | Hospitality | 2025 |
| Steves Home Heating Services Ltd | Manufacturing | 2024 |
| Steves News Ltd | Wholesale & retail | 2018 |
| Stewart & Taylor Properties Ltd | Real estate | 2017 |
| Stewart Sisters Limited | Real estate | 2017 |
| Stinchcombe Property Group Limited | Real estate | 2023 |
| STL Smartways Technology Limited | Professional & scientific | 1994 |
| Stockwyche Manor Limited | Real estate | 2025 |
| Stoneport Asset Management Limited | Transport & logistics | 1959 |
| Stoneport Holdings Ltd | Manufacturing | 2016 |
| Stoneridge Developments Limited | Construction | 1989 |
| Storks Boutique Ltd | Wholesale & retail | 2023 |
| Storm Bespoke Secondary Glazing Limited | Construction | 2009 |
| Storm Windows Holdings Limited | Financial services | 2021 |
| Stormin Development Ltd | Information & communication | 2025 |
| Stour Vale Academy Trust | Education | 2011 |
| Stourport Bars Ltd | Hospitality | 2023 |
| Strategic Workforce Development Consultancy Group Limited | Professional & scientific | 2024 |
| Strength Fabs Limited | Manufacturing | 2017 |
| Stress Solutions UK Limited | Professional & scientific | 2005 |
| Strive Homes Ltd | Real estate | 2021 |
| Structural Carpentry Limited | Manufacturing | 2011 |
| Structural Homes and Lettings Limited | Real estate | 2022 |