| Samra Property Developments Ltd | Professional & scientific | 2018 |
| Sand Land Ltd | Hospitality | 2025 |
| Sander Investments Ltd | Financial services | 2021 |
| Sandford Property Limited | Real estate | 2017 |
| Sandvik Limited | Manufacturing | 1914 |
| Sandwell Builders Ltd | Construction | 2011 |
| Sandwell Carpets and Vinyl Warehouse Ltd | Financial services | 2017 |
| Sandwell Carpets Limited | Wholesale & retail | 1989 |
| Sansi Limited | Wholesale & retail | 2017 |
| Saporito B63 Ltd | Hospitality | 2025 |
| SAR Projects Limited | Professional & scientific | 2013 |
| Sarah Gardner Consulting Limited | Other services | 2019 |
| Sarah Gibbs Limited | Hospitality | 2026 |
| Sarkawt Foods Ltd | Wholesale & retail | 2026 |
| Sarya Group Ltd | Administrative & support | 2026 |
| SAS Cleaning Limited | Administrative & support | 2017 |
| Sass Electrics Limited | Construction | 2018 |
| Satinskin Aesthetic Clinic Ltd | Other services | 2022 |
| Satori Ltd | Professional & scientific | 2025 |
| Savada Metal Finishing Limited | Professional & scientific | 1972 |
| Savannah Tents Limited | Arts & recreation | 2025 |
| Save a Million Lives | Administrative & support | 2005 |
| Savvy Store Wholesale Ltd | Wholesale & retail | 2025 |
| Sawtrax UK Ltd | Manufacturing | 2026 |
| Sbte Ltd | Information & communication | 2008 |
| Scaffold Services Midlands Ltd | Construction | 2017 |
| Scalp Doctor Ltd | Other services | 2013 |
| Scalpellus Limited | Health & social care | 2020 |
| Scan-X Security EOT Limited | Professional & scientific | 2026 |
| Scan-X Security Limited | Manufacturing | 2010 |
| Scan-X Service Limited | Administrative & support | 2021 |
| School Life Limited | Information & communication | 2020 |
| School of Maths and Science Ltd | Other services | 2015 |
| Scimitar Limited | Real estate | 2025 |
| SCM Funeral Directors Ltd | Other services | 2020 |
| Scott Haddock Estate Agents Ltd | Real estate | 2025 |
| SCR Site Management Ltd | Construction | 2025 |
| Screamers Limited | Transport & logistics | 2000 |
| Scruples Bromsgrove Limited | Other services | 2022 |
| SD Pubs Ltd | Hospitality | 2025 |
| SDC Scaffold Design Consultants Ltd | Construction | 2020 |
| Seagreen Consultancy Limited | Professional & scientific | 2018 |
| Sealco International Limited | Wholesale & retail | 1991 |
| Sealco Limited | Extraterritorial | 2009 |
| Seals and Industrial Services Limited | Wholesale & retail | 2025 |
| Seamcor Limited | Information & communication | 2005 |
| Seamvex Data Systems Ltd | Information & communication | 2026 |
| Sean Lintern Ltd | Administrative & support | 2016 |
| Second City Investments Ltd. | Extraterritorial | 1994 |
| Second City Leisure Limited | Administrative & support | 2013 |
| Second City Ventures Limited | Construction | 1996 |
| Secure Glaze Birmingham Ltd | Wholesale & retail | 2026 |
| Securiclear Aluminium Systems Limited | Manufacturing | 1990 |
| SEE Media Limited | Other services | 2014 |
| Seedhouse Ventures Limited | Real estate | 2023 |
| Seismic Consulting Ltd | Information & communication | 2024 |
| Selcraft UK Limited | Manufacturing | 1973 |
| Select Group Holdings Limited | Construction | 1982 |
| Select Instalations Limited | Construction | 2014 |
| Select Windows (Home Improvements) Limited | Manufacturing | 1991 |
| Selly Oak Lets Ltd | Real estate | 2020 |
| Sensor Security Services Limited | Public administration | 2016 |
| SEO Results Limited | Information & communication | 2021 |
| Serenity Electrical Services Ltd | Construction | 2023 |
| Sergent Ltd | Financial services | 2005 |
| Serpentine Properties Ltd | Construction | 2024 |
| Service Guaranteed Limited | Health & social care | 2024 |
| Seven Security Limited | Information & communication | 2017 |
| Severn Broadcast Media Limited | Information & communication | 2019 |
| SF6 Free Switchgear Limited | Wholesale & retail | 2025 |
| SFB Developments Ltd | Real estate | 2022 |
| SGK Solutions Ltd | Professional & scientific | 2025 |
| SGN Holdings Limited | Financial services | 2016 |
| Shaah Express Travel & Tours Ltd | Administrative & support | 2016 |
| Shaftmoor Lane Residents Management Company Limited | Households | 2022 |
| Shakir Property Ltd | Real estate | 2024 |
| Shankar Enterprises Limited | Real estate | 2021 |
| Sharifi Holdings Ltd | Real estate | 2026 |
| Sharp Tech Services Limited | Manufacturing | 2020 |
| Shaw Loos Limited | Administrative & support | 2003 |
| Shelah Properties Limited | Real estate | 2021 |
| Shelve IT Self Storage Ltd | Real estate | 2025 |
| Shenstone Estates Ltd | Real estate | 2026 |
| Shephards Motors Limited | Wholesale & retail | 2007 |
| Sheppard Property Limited | Real estate | 2020 |
| Shergill Developments (Midlands) Limited | Real estate | 2004 |
| Sheri Marketing Ltd | Wholesale & retail | 2025 |
| Shewra Properties Ltd | Real estate | 2025 |
| Shine Facilities Global Ltd | Administrative & support | 2024 |
| Shinecore Ltd | Administrative & support | 2025 |
| Shinestation Ltd | Administrative & support | 2025 |
| Shipfry Limited | Hospitality | 2026 |
| Shipley (Leisure) Enterprises Limited | Arts & recreation | 1977 |
| Shiraz and Sons Properties Ltd | Households | 2021 |
| Shire House Developments Limited | Extraterritorial | 2019 |
| Shire House Residents RTM Company Ltd | Households | 2010 |
| Shire Wooden Floors Limited | Construction | 2017 |
| Shires Medical Solutions Limited | Health & social care | 2013 |
| Shoei Gallery UK Limited | Wholesale & retail | 2025 |
| Shop Nezt Ltd | Wholesale & retail | 2024 |