| DJP Finance Limited | Administrative & support | 2015 |
| Dods-Tech Ltd | Construction | 2019 |
| DP Automotive Group Limited | Wholesale & retail | 2017 |
| Draycott & Kirk LLP | | 2021 |
| Drop and Go Laundry Services Ltd | Other services | 2023 |
| Dsproductions Ltd | Transport & logistics | 2025 |
| DTW Communications & Marketing Limited | Information & communication | 1988 |
| Durai Enterprises Ltd | Wholesale & retail | 2025 |
| DWE Electrical Testing and Installation Limited | Construction | 2016 |
| Dwela Limited | Real estate | 2017 |
| Dynamic Machine Tools Limited | Wholesale & retail | 2003 |
| Dynamic Machine Tools Servicing Limited | Manufacturing | 2010 |
| Eclf Teeside Ltd | Construction | 2026 |
| Eden Bakes & Brews Limited | Hospitality | 2025 |
| ELG Aesthetics Limited | Other services | 2024 |
| Elite Training Limited | Information & communication | 1999 |
| Ella Barbers Ltd | Other services | 2023 |
| Elrin Project Services Ltd | Professional & scientific | 2014 |
| Elunaluxe Aesthetics Limited | Other services | 2024 |
| Endless Findds Ltd | Wholesale & retail | 2025 |
| Energis AV Limited | Professional & scientific | 2022 |
| Energis Electricity Developments Limited | Professional & scientific | 2018 |
| Energis Property Limited | Real estate | 2022 |
| Energis UK Holdings Limited | Financial services | 2022 |
| Enfield Butchers Limited | Wholesale & retail | 2006 |
| Euremica Limited | Real estate | 1967 |
| European Subsea Cables Association | Other services | 2011 |
| Every MAN CAN CIC | Wholesale & retail | 2024 |
| Express One Car Wash Ltd | Administrative & support | 2025 |
| F & P Consult Limited | Professional & scientific | 2016 |
| F&F Offshore Services Ltd | Construction | 2026 |
| F.J. Booth Construction Limited | Construction | 2006 |
| Farecab Company Limited | Transport & logistics | 2021 |
| Farmhouse Kitchen & Coffee House Ltd | Hospitality | 2025 |
| Farndale HV Services Ltd | Energy | 2025 |
| Feed-Em Limited | Administrative & support | 2003 |
| FG 229 Limited | Hospitality | 2025 |
| FJ Booth Engineering Limited | Construction | 2019 |
| FJ Booth Limited | Construction | 2019 |
| FL Harding Logistics Ltd | Transport & logistics | 2025 |
| Fleur Harding Logistics Limited | Transport & logistics | 2025 |
| Folkescare Limited | Health & social care | 2008 |
| Foundry Rentals Ltd | Real estate | 2025 |
| Frame and Focus Photography Ltd | Wholesale & retail | 2023 |
| Fritto & Misto LLP | | 2017 |
| FRY Chicks Guisborough Ltd | Hospitality | 2025 |
| FRY Chiks Ltd | Hospitality | 2024 |
| Frychiks-Guisborough Ltd | Hospitality | 2025 |
| Full Bore Competitions Limited | Wholesale & retail | 2026 |
| G a Site Investigation Limited | Professional & scientific | 2009 |
| Galley Hill Farm Limited | Arts & recreation | 1975 |
| GAN Technical Services Limited | Professional & scientific | 2015 |
| Gardens Awakened Ltd | Administrative & support | 2022 |
| Gardens Revitalised Limited | Agriculture & fishing | 2004 |
| Geno's of Saltburn Ltd | Other services | 2024 |
| Georgia Rooney Limited | Professional & scientific | 2024 |
| Gisborough Priory Project Limited | Arts & recreation | 2003 |
| Gisborough Property Holdings Ltd | Professional & scientific | 2015 |
| GJJ Solutions Ltd | Professional & scientific | 2026 |
| Glow TAN Centre Ltd | Other services | 2021 |
| GME Fire Training & Risk Consultancy Limited | Professional & scientific | 2014 |
| GOD Gifts Ltd | Wholesale & retail | 2025 |
| Goddess Beauty Pro Cosmetics Ltd | Wholesale & retail | 2024 |
| Goldcrest Construction Limited | Construction | 1992 |
| Golden Light Therapy Limited | Health & social care | 2025 |
| Goldring-Lean-Consulting Limited | Professional & scientific | 2020 |
| Gracelands Care Home Limited | Health & social care | 1996 |
| Graham Electrical Energy Solutions Ltd | Construction | 2022 |
| Granite MIK Ltd | Construction | 2024 |
| Greenvale Properties Limited | Real estate | 1999 |
| Greythorpe Estates Ltd | Real estate | 2019 |
| Greythorpe Residential Ltd | Real estate | 2025 |
| Grizzly Wears Clothing Ltd | Wholesale & retail | 2021 |
| GTB Holdings Ltd | Financial services | 2020 |
| Guardyork Limited | Real estate | 1984 |
| Guisborough Angling Club Ltd | Agriculture & fishing | 2011 |
| Guisborough Bookshop Limited | Wholesale & retail | 2012 |
| Guisborough Car Sales Limited | Wholesale & retail | 2001 |
| Guisborough Cars Ltd | Administrative & support | 2019 |
| Guisborough Food Ltd | Hospitality | 2026 |
| Guisborough Funeral Services Ltd | Other services | 2021 |
| Guisborough Gateway Ltd | Hospitality | 2021 |
| Guisborough Hair Holdings Ltd | Other services | 2025 |
| Guisborough Mobile Physiotherapy Ltd | Health & social care | 2018 |
| Guisborough Model Flying Club Ltd | Administrative & support | 2017 |
| Guisborough Mortgage Centre Limited | Financial services | 2003 |
| Guisborough Museum Limited | Arts & recreation | 1990 |
| Guisborough Property Ltd | Real estate | 2013 |
| Guisborough Recycling Hub CIC | Wholesale & retail | 2019 |
| Guisborough Rugby Union Football Club Limited | Arts & recreation | 2017 |
| Guisborough Stores Ltd | Wholesale & retail | 2025 |
| Guisborough Tandoori Ltd | Hospitality | 2024 |
| Guisborough Town Football Club | Education | 2023 |
| Guisborough Town Hall Gateway Community Interest Company | Information & communication | 2020 |
| Guisborough Tyre & Brake Limited | Wholesale & retail | 2018 |
| H S Homes Limited | Real estate | 2007 |
| Hackneyg&C Limited | Professional & scientific | 2025 |
| Hall Financial Ltd | Financial services | 2017 |
| Hannah's Housekeeping Ltd | Administrative & support | 2023 |
| Harebrain Ltd | Extraterritorial | 2021 |