| SAN Damiano Corporation Ltd | Health & social care | 2012 |
| Sana Interiors Ltd | Construction | 2026 |
| Sandbell Limited | Households | 1981 |
| Sanderson & Rattray Productions Ltd | Arts & recreation | 2024 |
| Sandhay Capital Ltd | Financial services | 2025 |
| Sandhay Constructions Ltd | Construction | 2008 |
| Sandor's Construction Ltd | Administrative & support | 2020 |
| Sandown Estates Limited | Real estate | 2016 |
| Sangarde Consulting Limited | Professional & scientific | 2020 |
| Sangeetha SNK Optometric Services Ltd | Health & social care | 2023 |
| Sangiorgio Property Limited | Households | 2024 |
| Sanitrux Limited | Agriculture & fishing | 1966 |
| Sanjam Properties Ltd | Real estate | 2015 |
| Sanjida Trading Ltd | Real estate | 2025 |
| Sans Soucie Children Services Ltd | Health & social care | 2023 |
| Sans Soucie Home Care Ltd | Health & social care | 2010 |
| Santander Properties Limited | Real estate | 1993 |
| Santat Wines Limited | Wholesale & retail | 1988 |
| Sante Verte Limited | Wholesale & retail | 2003 |
| Santon Switchgear Limited | Wholesale & retail | 1996 |
| Santos Management Ltd | Households | 2018 |
| SAP Professional Solutions Ltd | Information & communication | 2017 |
| Saphar Limited | Professional & scientific | 2003 |
| Sapote Limited | Information & communication | 2020 |
| Sapphire Bookkeeping Limited | Professional & scientific | 2014 |
| Sarabande Management (UK) Limited | Professional & scientific | 2020 |
| Sarah Cave Associates Limited | Education | 2014 |
| Sarah Craven Limited | Administrative & support | 2025 |
| Sarah Dip'N'Tea Ltd | Hospitality | 2019 |
| Sarah Naylor Consulting Limited | Professional & scientific | 2018 |
| Sarah Ndagire Ltd | Arts & recreation | 2018 |
| Saro Technologies Limited | Information & communication | 2025 |
| Sarvat Consultancy Ltd | Administrative & support | 2022 |
| SAS Affinity Limited | Financial services | 2026 |
| SAS Guildford Limited | Wholesale & retail | 1987 |
| Sasbery Spirits Ltd | Manufacturing | 2019 |
| Sassaby 2 Limited | Professional & scientific | 2008 |
| Savabien Ltd | Information & communication | 2020 |
| Savalan Solutions Ltd | Construction | 2014 |
| Save a Space Limited | Information & communication | 2017 |
| Saxby Willson Limited | Information & communication | 2012 |
| Saxon Strategic Solutions Limited | Information & communication | 2010 |
| Sayben Construction (Devon) Ltd | Construction | 2024 |
| Sayben Construction Limited | Construction | 1983 |
| Sazk Limited | Wholesale & retail | 2008 |
| SB Aviation Interiors Ltd | Professional & scientific | 2023 |
| SB Real Estate Innovation Limited | Real estate | 2025 |
| SB Solar Ltd | Construction | 2018 |
| SBP2 Ltd | Professional & scientific | 2022 |
| SBS Invest Ltd | Real estate | 2025 |
| SC Braidz & Cutz Ltd | Wholesale & retail | 2026 |
| SC Holiday Clubs Limited | Health & social care | 2023 |
| Scaleupdata Limited | Information & communication | 2022 |
| Scanvet UK Limited | Real estate | 1980 |
| Scaramango Technologies Limited | Professional & scientific | 2019 |
| Scarlett Property Ltd | Real estate | 2018 |
| Scattergoods Agency Limited | Administrative & support | 1995 |
| SCB Estates Limited | Real estate | 2021 |
| SCD Architects Limited | Professional & scientific | 2008 |
| SCH Management Limited | Hospitality | 1996 |
| Schiltron Engineering Consultancy Ltd | Professional & scientific | 2022 |
| Schmittzehe and Partners Legal Limited | Professional & scientific | 2012 |
| Scholar Properties Limited | Real estate | 2020 |
| School Zone Limited | Wholesale & retail | 1998 |
| Scibids Technology UK Ltd | Information & communication | 2019 |
| Sciecure Pharma Limited | Manufacturing | 2013 |
| Science Applications International Corporation (UK) Limited | Professional & scientific | 2024 |
| Sciqglobal Ltd | Professional & scientific | 2025 |
| Scitech Trustee Limited | Administrative & support | 2011 |
| Sckj Ltd | Financial services | 2026 |
| Sclk Consulting Limited | Health & social care | 2016 |
| Scope Medical Group Ltd | Health & social care | 2014 |
| Scope Medical Ltd | Health & social care | 2014 |
| Scope Medical Training Ltd | Education | 2014 |
| Scrivener Hall Limited | Information & communication | 2010 |
| Scroll Nation Limited | Professional & scientific | 2016 |
| Sctmobile Limited | Real estate | 2007 |
| Scully Consulting Limited | Information & communication | 2015 |
| Sculpture Management Limited | Arts & recreation | 2007 |
| SDG Music Ltd | Arts & recreation | 2013 |
| Seaglass Films Limited | Information & communication | 2025 |
| Seahorse Services Ltd | Professional & scientific | 2013 |
| Seamless Properties Ltd | Real estate | 2021 |
| Searcher Publications Limited | Wholesale & retail | 2005 |
| Searchkeep Limited | Real estate | 1992 |
| Searle Accounting Solutions Limited | Professional & scientific | 2017 |
| Seasonstory Limited | Financial services | 2025 |
| Seaspray Management Company Limited | Real estate | 2004 |
| Secheli Joinery & Carpentry Contractors Ltd | Construction | 2015 |
| Second Avondale Residents Association Limited | Households | 1980 |
| Second York Limited | Administrative & support | 2009 |
| Secret Garden Guildford Limited | Wholesale & retail | 2017 |
| Secure Data Recovery UK Ltd | Information & communication | 2024 |
| Secure Email Hosting Limited | Information & communication | 2009 |
| Securly Limited | Administrative & support | 2019 |
| Securta Ltd | Construction | 2025 |
| Sedgemoor Group Pension Trustees Limited | Financial services | 1987 |
| Sedgemoor Group Supplementary Pension Trustees Limited | Professional & scientific | 1987 |
| Sedgemoor Holdings Limited | Professional & scientific | 1997 |
| Sedgemoor Limited | Professional & scientific | 1934 |