| Stevens Seafoods Limited | Wholesale & retail | 2002 |
| Stevenson Motors Limited | Wholesale & retail | 2022 |
| Stevie Jayne Ltd | Hospitality | 2020 |
| Stevie Scaffolding Limited | Construction | 2019 |
| Stftrans Ltd | Transport & logistics | 2025 |
| Stick and Ship Limited | Administrative & support | 2025 |
| Stirling Defence Limited | Administrative & support | 2015 |
| Stitch Express Grimsby Limited | Other services | 2025 |
| Stmem Trading Limited | Wholesale & retail | 2025 |
| Stockology Ltd | Professional & scientific | 2015 |
| Stocks Heating Limited | Construction | 2026 |
| Stolz Limited | Other services | 2016 |
| Stonebow Media Limited | Information & communication | 2010 |
| Stones Aviation Holdings Limited | Transport & logistics | 2025 |
| Stones Family Holdings Limited | Financial services | 2026 |
| Stones Legal Holdings Limited | Financial services | 2026 |
| Stones Property Holdings Limited | Financial services | 2026 |
| Story INK Coffee Limited | Hospitality | 2019 |
| Storyours Limited | Information & communication | 2025 |
| Strafford Investments Ltd | Administrative & support | 2024 |
| Strategic BI Consult Ltd | Information & communication | 2022 |
| Strenghdeptuk Ltd | Arts & recreation | 2018 |
| Stretford Consultancy Services Limited | Construction | 2022 |
| Stride Building Services Limited | Construction | 2020 |
| Strideout 2025 Limited | Health & social care | 2025 |
| Strideout Ltd | Health & social care | 2010 |
| Stroke Links CIC | Other services | 2021 |
| Stromps U.K. Limited | Transport & logistics | 1983 |
| Stroud Vehicle Solutions Ltd | Wholesale & retail | 2018 |
| Stroykins 1978 Limited | Extraterritorial | 2014 |
| Structural Joinery Limited | Construction | 2013 |
| Stuart King Properties Limited | Real estate | 2022 |
| Stuart Margarson Plastering Ltd | Construction | 2024 |
| Stuart Nicholls K9 Security Ltd | Administrative & support | 2022 |
| Studentmobilephones.Com Ltd | Wholesale & retail | 2016 |
| Studio 36 Ltd. | Manufacturing | 2006 |
| Studio a Barber Shop Limited | Other services | 2019 |
| Studio a Hair Salon - Barber Shop Ltd. | Other services | 2015 |
| Studio Fibre Ltd | Professional & scientific | 2006 |
| Studio SP Limited | Professional & scientific | 2025 |
| Studiofettle Ltd | Arts & recreation | 2019 |
| Sturdy Groundworks Ltd | Construction | 2017 |
| Style a Tile Limited | Construction | 2019 |
| Style Ceiling & Wall Systems Limited | Construction | 2003 |
| Suaib Trade Ltd | Wholesale & retail | 2026 |
| SUBCON5 Limited | Professional & scientific | 2018 |
| Subzero (Grimsby) Limited | Manufacturing | 2016 |
| Suchi Medical Ltd | Health & social care | 2015 |
| Suiopn Limited | Wholesale & retail | 2021 |
| Suki Suan Ltd | Health & social care | 2016 |
| Sula Risk Management Limited | Administrative & support | 2022 |
| Sultan of Sutton Limited | Hospitality | 2022 |
| SUM Technical Services Ltd | Manufacturing | 2013 |
| Sumba Botanicals Limited | Manufacturing | 2025 |
| Summer Days Transport Limited | Transport & logistics | 2014 |
| Summers Lakeside Lodges Limited | Hospitality | 2019 |
| Summers LOG Cabins Ltd | Hospitality | 2020 |
| Summers Paradise Ltd | Hospitality | 2018 |
| Summers Plots Ltd | Hospitality | 2018 |
| Sun AMG Limited | Manufacturing | 2023 |
| Sunbow Fishing Company Limited | Administrative & support | 1976 |
| Sunderwo Engineering Limited | Professional & scientific | 2016 |
| Sunningdale 62 Limited | Extraterritorial | 2013 |
| Sunny Commercial Property Ltd | Real estate | 2025 |
| Sunny Property Development and Management Limited | Real estate | 2021 |
| Sunnys Safety Limited | Other services | 2025 |
| Sunnyside Ground Maintenance Limited | Administrative & support | 2002 |
| Sunnyside Pizza Ltd | Hospitality | 2026 |
| Sunnyview Conservatories Limited | Construction | 1996 |
| Sunshine Grimsby Ltd | Hospitality | 2025 |
| Sunshine Holistic Care Limited | Health & social care | 2025 |
| Sunshine Hub Limited | Administrative & support | 2025 |
| Sunshine Pictures Limited | Information & communication | 2017 |
| Superior Cutting Limited | Manufacturing | 2013 |
| Supply Drop Ltd | Wholesale & retail | 2018 |
| Support 2 Flourish Ltd | Health & social care | 2019 |
| Support Instrumentation Limited | Wholesale & retail | 1998 |
| Support Staff Services Limited | Administrative & support | 2012 |
| Supported Living Propco Ltd | Households | 2019 |
| Supreme Powder Finish Limited | Manufacturing | 2018 |
| Supreme Roofing Services Limited | Construction | 2016 |
| Supreme Seafood Ltd | Wholesale & retail | 2019 |
| Supreme Spuds GY Ltd | Hospitality | 2025 |
| Surestyle Shutters Ltd | Other services | 2025 |
| Sureview Limited | Administrative & support | 2017 |
| Surface Dsgn Ltd | Professional & scientific | 2018 |
| Surfaces & Groundworks Ltd | Construction | 2017 |
| Surfleet's Plumbing & Heating Ltd | Construction | 2026 |
| Surge Mechanical Ltd | Construction | 2023 |
| Surreal Flat Roofing UK Ltd | Construction | 2017 |
| Surrey Fire and Security Ltd | Administrative & support | 2017 |
| Survan Ltd | Professional & scientific | 2007 |
| Susan Baines Consultancy Limited | Professional & scientific | 2023 |
| Sutton Bean Limited | Administrative & support | 1993 |
| Suttons Property Limited | Real estate | 2025 |
| SV Inns Ltd | Real estate | 2009 |
| SV Retail Sales Ltd | Wholesale & retail | 2025 |
| SVA Logistics Ltd | Transport & logistics | 2023 |
| Svic Holdings Ltd | Financial services | 2025 |
| Svinnur UK Limited | Financial services | 2011 |