| SC Rugs and Homeware Limited | Manufacturing | 2016 |
| SCA Properties (Lincolnshire) Limited | Real estate | 2025 |
| Scaffmag Limited | Information & communication | 2018 |
| Scalp Innovations Limited | Health & social care | 2016 |
| Scangrit Ltd. | Transport & logistics | 1995 |
| Scarlett Steel Limited | Construction | 2016 |
| Scartho Cars Ltd | Transport & logistics | 2022 |
| Scartho Dental Care Limited | Health & social care | 2012 |
| Scartho Eyecare Limited | Wholesale & retail | 2014 |
| Scartho Finance Company Limited | Financial services | 1962 |
| Scartho Fisheries Limited | Hospitality | 2014 |
| Scartho Junior Academy Limited | Education | 2011 |
| Scartho News Extra Limited | Wholesale & retail | 2019 |
| Sccm Consultants Ltd | Information & communication | 2013 |
| Scentify Ltd | Wholesale & retail | 2024 |
| Schofield Enterprises Limited | Real estate | 2009 |
| School of Risk Ltd | Professional & scientific | 2017 |
| Scilla Rose Limited | Other services | 2018 |
| SCL Consulting Solutions Ltd | Information & communication | 2018 |
| SCM Delivery Ltd | Transport & logistics | 2025 |
| SCM Trans&Repair Ltd | Manufacturing | 2020 |
| Scott Services Lincs Ltd | Construction | 2025 |
| Scott's Meats Ltd | Wholesale & retail | 2021 |
| Scottnog Ltd | Construction | 2020 |
| Scratch Meals Ltd | Manufacturing | 2009 |
| Scream Brewing Company Ltd | Manufacturing | 2025 |
| Scunthorpe Sweeper Hire Ltd | Water & waste | 2020 |
| SCV Logistics Ltd | Transport & logistics | 2025 |
| SD Green Energy Limited | Manufacturing | 2025 |
| SD Plumbing Services by Warm Assure Ltd | Construction | 2015 |
| SD Services Humber Ltd | Construction | 2025 |
| SD Welding & Inspection Services Ltd | Professional & scientific | 2020 |
| SDB Access & NDT Services Ltd | Professional & scientific | 2025 |
| SDB Mechanical Services Limited | Wholesale & retail | 2025 |
| SDG Services Limited | Water & waste | 2018 |
| Sdjb Bolt Technicians Limited | Construction | 2018 |
| Seafish Processing Limited | Manufacturing | 2017 |
| Seafish Sales Limited | Wholesale & retail | 2017 |
| Seafood Cottage Limited Partnership | | 2012 |
| Seafood Direct UK Ltd | Wholesale & retail | 2019 |
| Seafood Grimsby & Humber Alliance Limited | Wholesale & retail | 2020 |
| Seafreeze Limited | Wholesale & retail | 2002 |
| Seaside Cleans Ltd | Administrative & support | 2025 |
| Seaspray Marine Ltd | Construction | 2018 |
| Seaview Cleethorpes Limited | Manufacturing | 2002 |
| Seaview Garden Services Ltd | Administrative & support | 2025 |
| SEB & Jovi Ltd | Transport & logistics | 2023 |
| Secret Seas Ltd | Hospitality | 2023 |
| Secret Surgery Limited | Health & social care | 2010 |
| Securefx Solutions Ltd | Information & communication | 2025 |
| Seel Engineering Solutions (SES) Ltd | Professional & scientific | 2022 |
| Select Cars Grimsby Limited | Real estate | 2011 |
| Select Executive Travel Ltd | Transport & logistics | 2023 |
| Selectarrow Ltd | Information & communication | 2019 |
| Selin Maria Transport Ltd | Transport & logistics | 2026 |
| Selsig Limited | Information & communication | 2018 |
| Selvic Handling & Warehousing Limited | Transport & logistics | 1993 |
| Selvic Shipping Services Limited | Transport & logistics | 1977 |
| Send Friends Support CIC | Education | 2025 |
| Sensory Cinema UK CIC | Health & social care | 2023 |
| Sentinel Management Solutions Ltd | Information & communication | 2026 |
| Senvo UK Ltd | Wholesale & retail | 2018 |
| Seoulia Ltd | Wholesale & retail | 2026 |
| Serene Home Solutions Ltd | Real estate | 2023 |
| Serks Security Ltd | Administrative & support | 2019 |
| Sermo Automation Ltd | Manufacturing | 2026 |
| Servat Construction Ltd | Professional & scientific | 2018 |
| Service With a Tile (Anglia) Limited | Other services | 2016 |
| Servicentric Ltd | Information & communication | 2019 |
| Setdec Limited | Construction | 2010 |
| Seth and Bear Ltd | Wholesale & retail | 2020 |
| Seva (UK) Ltd | Hospitality | 2014 |
| Seven Grey Futures Limited | Wholesale & retail | 2015 |
| Seven Stars Car Wash Ltd | Wholesale & retail | 2023 |
| SEW Perfectly Enchanted Ltd | Wholesale & retail | 2025 |
| Seyab Limited | Real estate | 1974 |
| SFA Estates Limited | Real estate | 2025 |
| Sfbb Training Ltd | Professional & scientific | 2025 |
| Shackleton House Management Limited | Real estate | 2007 |
| Shadow Construction Site Management Limited | Construction | 2006 |
| Shadows of Beauty Ltd | Extraterritorial | 2024 |
| Shaf JB Ltd | Health & social care | 2022 |
| Shahi Online Store Ltd | Wholesale & retail | 2017 |
| Shamrock Property Services Ltd | Construction | 2025 |
| Shand Property Ltd | Real estate | 2024 |
| Shapeu Personal Training Limited | Other services | 2017 |
| Sharon Carr Limited | Professional & scientific | 2012 |
| Sharper Engineering Ltd | Professional & scientific | 2024 |
| Sharpfish Limited | Manufacturing | 2001 |
| Shaun Dufty Limited | Professional & scientific | 2020 |
| Shaun Jackson Electrical Limited | Construction | 2015 |
| Shdw Operations Limited | Construction | 2015 |
| Shearer Bar Limited | Hospitality | 2026 |
| Sheilds Vocational Training Limited | Education | 2014 |
| Shekas Retail Ltd | Wholesale & retail | 2010 |
| Shellbay Composites Limited | Construction | 2009 |
| Shelphen Care Limited | Extraterritorial | 1989 |
| Shen Hand Car Wash Ltd | Wholesale & retail | 2024 |
| Shephard Estates Ltd | Real estate | 2023 |
| Shepherd Management Consultancy Limited | Administrative & support | 2014 |