| SC Works Limited | Administrative & support | 2005 |
| Sckc Electrical Ltd | Manufacturing | 2017 |
| Scotesports CIC | Arts & recreation | 2024 |
| Scott & Turley Limited | Administrative & support | 2019 |
| Scott Deeney Contract Services Limited | Wholesale & retail | 2025 |
| Scotts Takeaway Ltd | Hospitality | 2025 |
| Sdbl Holdings Limited | Real estate | 2024 |
| SDR Development Group Ltd | Construction | 2026 |
| SE7EN Store Plus Ltd | Wholesale & retail | 2025 |
| Seagull Workshop Ltd | Real estate | 2020 |
| Secret Salon PG Limited | Other services | 2018 |
| Securescot Limited | Administrative & support | 2006 |
| Seil Investments Limited | Real estate | 2020 |
| Self Care by Sophie Ltd | Other services | 2025 |
| Selkie Trading Limited | Hospitality | 2026 |
| Semiconductor Technology Limited | Manufacturing | 2014 |
| Serca Tours Ltd | Transport & logistics | 2022 |
| Sercom Solutions | | 1993 |
| Serene Recovery Lounge Ltd | Other services | 2026 |
| Serial Grillers Ltd | Hospitality | 2020 |
| Sfark Ltd | Wholesale & retail | 2025 |
| SG News Ltd | Wholesale & retail | 2017 |
| SGK Property Limited | Real estate | 2018 |
| SGK Retail Group Limited | Wholesale & retail | 2021 |
| Shah Safeer Sweet House Ltd | Hospitality | 2014 |
| Shining House Ltd | Wholesale & retail | 2022 |
| Ships' Accommodation Solutions Ltd. | Professional & scientific | 2005 |
| Shipyard GIN (Scotland) Limited | Wholesale & retail | 2021 |
| Shivil Limited | Wholesale & retail | 2018 |
| Shopperboss Limited | Wholesale & retail | 2022 |
| Silent Stories Ltd | Health & social care | 2024 |
| Silera Limited | Professional & scientific | 2008 |
| Silver Labs Ltd | Manufacturing | 2019 |
| Simply Central Heating & Plumbing Ltd | Wholesale & retail | 2020 |
| Singing Spaces CIC | Education | 2023 |
| Sisterco Limited | Hospitality | 2019 |
| Sizzle & Cream Limited | Hospitality | 2022 |
| Skandiaverken Ltd. | Wholesale & retail | 1999 |
| Skim Foods Limited | Hospitality | 2024 |
| Skim Properties Limited | Real estate | 2023 |
| Skye Stays Ltd | Real estate | 2024 |
| Skypics (Scotland) Limited | Information & communication | 2025 |
| Slate Island Developments Limited | Real estate | 2020 |
| Slushed Desserts Limited | Hospitality | 2024 |
| Slushed Ltd | Hospitality | 2021 |
| SM Leisure Limited | Other services | 2014 |
| SM Taxi Services Inverclyde Limited | Transport & logistics | 2011 |
| Smart Marketing for Accountants Limited | Other services | 2019 |
| Smart Property Lets Ltd | Real estate | 2022 |
| SMC Digital Tech Ltd | Information & communication | 2025 |
| SMC Property Development Ltd. | Real estate | 2003 |
| Smcv Ltd | Construction | 2017 |
| Smith Access Services Ltd | Construction | 2025 |
| Smoothie Bros Ltd | Hospitality | 2025 |
| Smoothie Cruisers Ltd. | Extraterritorial | 2007 |
| Smze Courier Services Ltd | Transport & logistics | 2025 |
| Snowbird Investments Limited | Professional & scientific | 2002 |
| Snowbird Property Limited | Real estate | 2002 |
| Soluxe Tanning Limited | Wholesale & retail | 2025 |
| South Lanarkshire Building Supplies Limited | Extraterritorial | 2019 |
| Spartan Specialist Services Ltd | Construction | 2018 |
| Spence Textiles Limited | Wholesale & retail | 2020 |
| Spike Multimedia Limited | Information & communication | 2005 |
| Split Clothing Limited | Wholesale & retail | 2021 |
| Spno Training & Logistics Ltd | Education | 2015 |
| Sportsco Limited | Extraterritorial | 2013 |
| Spot.Drinks Ltd | Manufacturing | 2025 |
| Squared Insurance Brokers Limited | Financial services | 2019 |
| SRA Wash Ltd | Other services | 2025 |
| Srush Paint Ltd | Construction | 2023 |
| Stage & Logistics International Ltd | Professional & scientific | 2015 |
| Star WOK 168 Ltd | Hospitality | 2025 |
| STATION08 Ltd | Wholesale & retail | 2025 |
| Stellar and Stars Ltd | Wholesale & retail | 2023 |
| Stepwell Consultancy Ltd. | Health & social care | 2008 |
| Stevenson FMS Ltd | Construction | 2025 |
| Stewart's Hair & Beauty Limited | Other services | 2012 |
| Stirling Marine Consultancy Ltd | Other services | 2010 |
| Stirrat Group Limited | Manufacturing | 2015 |
| Stubhill Limited | Wholesale & retail | 2019 |
| Style Diva Ltd | Extraterritorial | 2025 |
| Subiaco Investment Holdings Limited | Real estate | 2012 |
| Swan Grace Pilates (Greenock) Ltd | Arts & recreation | 2026 |
| Sweeney Bookkeeping Ltd | Professional & scientific | 2025 |
| Swilcan Holdings Limited | Construction | 2025 |
| Swordfish Signs Limited | Professional & scientific | 2004 |
| Syed Grocery Ltd | Wholesale & retail | 2024 |
| Symington Welding Services Limited | Construction | 1997 |
| Systemsdash Services Limited | Information & communication | 2025 |
| Tall Tale Creative Ltd | Professional & scientific | 2021 |
| Tartan Energy Ltd | Energy | 2025 |
| Tartan House Construction Ltd | Construction | 2013 |
| Tartan Tarmac LLP | | 2015 |
| Taylor Telecommunications Ltd. | Information & communication | 2007 |
| Taylormade Trinkets Ltd | Wholesale & retail | 2025 |
| Teaglach MCB Ltd | Professional & scientific | 2023 |
| Team Guardian Ltd | Administrative & support | 2024 |
| Tech & Travel Ltd | Other services | 2020 |
| Tekkeys Ltd | Wholesale & retail | 2023 |
| Tenebrarius Limited | Professional & scientific | 2023 |