| Sabre Systems Limited | Construction | 2012 |
| SAE Systems Limited | Administrative & support | 2005 |
| Safe Access Scaffold Ltd | Construction | 2019 |
| Safe STS Limited | Administrative & support | 2009 |
| Safe STS LNG Limited | Administrative & support | 2009 |
| Safe STS Transfer Technology Ltd | Transport & logistics | 2020 |
| Saga Crown Pallets Limited | Manufacturing | 2013 |
| Saint Virgo Clothing Limited | Wholesale & retail | 2021 |
| Sala Tonkin Limited | Construction | 2019 |
| Salty Sauna Ltd | Other services | 2025 |
| Salus Technical Solutions Ltd | Administrative & support | 2022 |
| SAM Holdings (2007) Limited | Manufacturing | 2006 |
| Samanthal Limited | Information & communication | 2020 |
| Samphire Trading Ltd | Real estate | 2019 |
| Samuel Aldred Limited | Financial services | 2023 |
| Samuel Grace Limited | Education | 2003 |
| Sand (Norfolk) Limited | Hospitality | 2020 |
| Sanderson Marine Craft Limited | Hospitality | 1947 |
| Sands Agricultural Finance Limited | Administrative & support | 1997 |
| Sands Agricultural Machinery Limited | Manufacturing | 1973 |
| Sands Engineering & Fabrications Limited | Extraterritorial | 1994 |
| Sandscratchers Ltd | Hospitality | 2021 |
| Sandy Dental Care Limited | Health & social care | 2022 |
| Sannick Group Limited | Professional & scientific | 2016 |
| Sar-Cel Energy Limited | Manufacturing | 2016 |
| Sarah Godbolt Limited | Health & social care | 2010 |
| Sararebi Ltd | Transport & logistics | 2022 |
| SAS Lasercutting Services Ltd | Extraterritorial | 2012 |
| SAS Sheetmetal & Fabrication Limited | Manufacturing | 2006 |
| SAT Phones Direct Limited | Information & communication | 1997 |
| Saturn Accountancy Services Ltd | Professional & scientific | 2011 |
| Saturn Healthcare (Holdings) Ltd | Financial services | 2010 |
| Saturn Healthcare Investments Limited | Financial services | 2016 |
| Saturn Healthcare Ltd | Health & social care | 2011 |
| Saturn Healthcare Properties Limited | Construction | 2025 |
| Saul's Flooring Ltd | Construction | 2020 |
| Saules Trans Ltd | Transport & logistics | 2019 |
| Save Hemsby Coastline | Professional & scientific | 2014 |
| Save the World Ltd | Administrative & support | 2022 |
| Sawley Ventures Limited | Financial services | 2019 |
| Sbcrosby Holdings Ltd | Real estate | 2020 |
| SBDP1 Limited | Health & social care | 2008 |
| SBP Home Improvements Limited | Construction | 2020 |
| SBS Care Homes Limited | Extraterritorial | 2014 |
| SC Contractors GY Ltd | Construction | 2026 |
| Scanners Limited | Information & communication | 1993 |
| Scarlet Poppy Property Investments Ltd | Real estate | 2022 |
| Scarnol Developments Ltd | Construction | 2021 |
| Scels Limited | Health & social care | 2013 |
| Schmidt Dental Limited | Health & social care | 2022 |
| Schneider Removals Ltd | Transport & logistics | 2023 |
| SCJ Services Limited | Mining & quarrying | 2024 |
| Scorpeo UK Limited | Financial services | 2012 |
| Scotsdale Laundry (Cambridge) Limited | Extraterritorial | 1946 |
| Scott Engineering Ltd | Professional & scientific | 2023 |
| Scott High Limited | Construction | 2008 |
| Scott Robert Vincent Properties Limited | Real estate | 2023 |
| Scott. a. Engineering Ltd | Construction | 2019 |
| Scotts Inns Limited | Hospitality | 2008 |
| Scratby Garden Centre Limited | Wholesale & retail | 1971 |
| Scratby Hall Caravan Park Limited | Hospitality | 1961 |
| Scribbles Day Nursery (Beacon Park) Limited | Education | 2018 |
| Scribbles Day Nursery (Gorleston) Ltd | Health & social care | 2013 |
| Scribbles Day Nursery (Seashore) Limited | Education | 2024 |
| Scroby Fayre Estates Limited | Real estate | 2002 |
| Scroby Fayre Limited | Real estate | 1979 |
| Scully Group Ltd | Other services | 2025 |
| SDC (GY) Limited | Construction | 2021 |
| Sddh Management Limited | Real estate | 2022 |
| Sdeg Limited | Wholesale & retail | 2006 |
| Sdhc Limited | Financial services | 2015 |
| Sdmra Limited | Mining & quarrying | 2022 |
| Sea and Land Fabrication Ltd | Manufacturing | 2021 |
| Sea Breeze Coastal Apartments Ltd | Real estate | 2024 |
| Sea JET Systems Limited | Mining & quarrying | 2022 |
| Sea View Guest House Ltd | Hospitality | 2019 |
| Sea View Stay Limited | Hospitality | 2022 |
| Seabed Scour Control Systems Limited | Manufacturing | 1990 |
| Seadell Shops Limited | Wholesale & retail | 2002 |
| Seafield Court Apartments Ltd | Real estate | 2020 |
| Seagull Garage Limited | Real estate | 1969 |
| Seagull Geotechnics Limited | Professional & scientific | 2015 |
| Seagull Private Hire Ltd | Transport & logistics | 2016 |
| Seahorse 2025 Ltd | Hospitality | 2025 |
| Seakins Property Solutions Limited | Real estate | 2025 |
| Seakins Storage Limited | Transport & logistics | 2001 |
| Sean's Cave Ltd | Wholesale & retail | 2022 |
| Searle & Partners Limited | Hospitality | 2009 |
| Searle Building Surveyors Ltd. | Professional & scientific | 2013 |
| Searleco Ltd | Professional & scientific | 2022 |
| Seaserve Ltd | Other services | 2023 |
| Seatrax (U.K.) Limited | Manufacturing | 1994 |
| Seatrax Equipment Services (UK) Limited | Extraterritorial | 2019 |
| Secunda Intentio Ltd | Education | 2021 |
| Secure IT Solutions Limited | Information & communication | 2025 |
| Secure Tours Limited | Real estate | 2002 |
| Security Partner Ltd | Administrative & support | 2021 |
| Seek OIL & GAS Services Limited | Mining & quarrying | 2023 |
| Seetrang Ltd | Hospitality | 2019 |
| Sefton Holiday Rentals Limited | Hospitality | 2025 |