| Southfleet Home Solutions Ltd | Construction | 2026 |
| Sovereign Estates & Management Ltd. | Extraterritorial | 1986 |
| Sovereign Hair Ltd | Wholesale & retail | 2023 |
| SP Asset Finance Ltd | Financial services | 2025 |
| SP Asset Investments Ltd | Real estate | 2024 |
| SP Asset Management Ltd | Households | 2025 |
| SP Blue Solutions Ltd | Transport & logistics | 2018 |
| SP Investment Solutions Ltd | Real estate | 2025 |
| SP Jointing Services Limited | Construction | 2024 |
| Spa Transport Ltd | Transport & logistics | 2017 |
| Spaak Ltd | Wholesale & retail | 2022 |
| Spark Construction Ltd | Construction | 2015 |
| Sparkle and Shield Solutions Ltd. | Other services | 2024 |
| Sparkling Fairy Services Ltd | Construction | 2023 |
| Sparkling Property Services Ltd | Administrative & support | 2009 |
| Sparklingfingers Ltd | Administrative & support | 2025 |
| Sparks & Co (Builders Merchants) Limited | Wholesale & retail | 1975 |
| Spathom Ltd | Information & communication | 2023 |
| SPC Brickwork Contractors Limited | Construction | 2012 |
| Spec Event Decorations Limited | Energy | 2016 |
| Spec Gas-Electrics and Facilities Management Limited | Construction | 2021 |
| Specialist RAW Pet Foods Ltd | Wholesale & retail | 2018 |
| Specialist Rendering Services Ltd | Construction | 2011 |
| Spectrum Engineering & Transmission Company Limited | Professional & scientific | 1992 |
| Spectrum Flooring Ltd | Construction | 2025 |
| Spectrum Immigration and Employment Ltd | Administrative & support | 2021 |
| Spectrum Maintenance Ltd | Construction | 2023 |
| Spectrum Management Company Limited | Real estate | 1988 |
| Speed MP Ltd | Transport & logistics | 2019 |
| Spencer West Partnership Ltd | Professional & scientific | 2023 |
| Spica Properties Limited | Real estate | 2025 |
| Spices Asian Food Ltd | Wholesale & retail | 2022 |
| Spice’S of India (Meopham) Ltd | Hospitality | 2026 |
| Spin & Chill Lounge Ltd | Wholesale & retail | 2025 |
| Spin Physio Ltd | Health & social care | 2019 |
| Spindle Developments Limited | Real estate | 2018 |
| Spindles Carpentry and Construction Ltd | Construction | 2022 |
| Spinnaker Developments Ltd | Construction | 2017 |
| Spinux Solutions Ltd | Information & communication | 2024 |
| Spiralo Ltd | Transport & logistics | 2025 |
| Spirits of the Revolution Ltd | Professional & scientific | 2012 |
| Spital Investments Limited | Real estate | 2021 |
| SPM Group Ltd | Administrative & support | 2016 |
| Spoons and Coasters Limited | Wholesale & retail | 2023 |
| SPORTSCARE4YOU Limited | Health & social care | 2024 |
| Spotless G Clean Limited | Administrative & support | 2025 |
| Sprayed Concrete Limited | Extraterritorial | 2005 |
| Springhead Health Limited | Health & social care | 2019 |
| Springhead Security Facility Management Ltd | Financial services | 2023 |
| Springrain Consult Limited | Information & communication | 2024 |
| Springvale Contractors Limited | Extraterritorial | 1976 |
| Sprint Engineering and Lubricants Ltd | Wholesale & retail | 1989 |
| Sprint Engineering Services Limited | Manufacturing | 2006 |
| Sprint Lubricant Services Limited | Wholesale & retail | 1992 |
| Sps-Uk Limited | Manufacturing | 2022 |
| Spss QS Ltd | Professional & scientific | 2021 |
| Spsworks Limited | Professional & scientific | 2016 |
| SQR Security Ltd | Extraterritorial | 2025 |
| Squareface Ltd | Professional & scientific | 2021 |
| Squiffy Ltd | Wholesale & retail | 2023 |
| Squires Carpentry Limited | Manufacturing | 2016 |
| SR Chahal Ltd | Real estate | 2026 |
| SR Hills Electrical Services Ltd | Construction | 2009 |
| SR Hub Ltd | Financial services | 2023 |
| Srgs Properties Ltd | Real estate | 2023 |
| SRI Neelakanta Ltd | Hospitality | 2025 |
| SRJ Construction Ltd | Construction | 2026 |
| SRP Financial Ltd | Financial services | 2011 |
| SS Construction (Kent) Ltd | Construction | 2023 |
| SS Contraction Limited Limited | Construction | 2025 |
| SSA Construction Service Limited | Construction | 2014 |
| Ssdl Limited | Information & communication | 2023 |
| Ssenyondo Terrie Tyra Ltd | Health & social care | 2014 |
| SSS Construction Services Ltd | Construction | 2019 |
| Sstharun Limited | Wholesale & retail | 2026 |
| Sstm Transport Ltd | Water & waste | 2011 |
| ST Clements Lakes Management Company Limited | Households | 2016 |
| ST James Court (Gillingham) Management Company Limited | Households | 2002 |
| ST James Properties Ltd | Real estate | 2024 |
| ST James' Mews Management Company (Leeds) Limited | Real estate | 2004 |
| ST Thomas Hill Homes Ltd | Real estate | 2020 |
| ST. Annes Court Limited | Households | 1997 |
| ST. Clements Close Management Company Limited | Households | 1993 |
| ST. Edith's Pre-School Limited | Education | 2005 |
| Stableguard Security Solutions Ltd | Public administration | 2023 |
| Staff Joinery Limited | Professional & scientific | 2014 |
| Stallion Investments & Development Ltd | Professional & scientific | 2021 |
| Stan Construction Limited | Construction | 2014 |
| Stan Enterprise Limited | Transport & logistics | 2018 |
| Stan&N Services Limited | Construction | 2019 |
| Standbuild Masters Ltd | Administrative & support | 2025 |
| Standby Cabling Ltd | Construction | 2025 |
| Standon News Ltd | Wholesale & retail | 2014 |
| Stanhill Farms Limited | Real estate | 1947 |
| Stanhope (Site 2) Management Company Limited | Real estate | 2010 |
| Stanhope (Site 3) Management Company Limited | Real estate | 2008 |
| Stanica Trans Limited | Transport & logistics | 2017 |
| Stanton Court (RM10) RTM Company Limited | Households | 2019 |
| Star Engineering Holdings Limited | Financial services | 2017 |
| Star Holdings Group Ltd | Financial services | 2024 |