| Rugcraft Limited | Wholesale & retail | 2021 |
| Rummel Ltd | Health & social care | 2014 |
| Runcie Ltd | Professional & scientific | 2023 |
| Russell 3 Property Limited | Real estate | 2024 |
| S & J Green Solutions Limited | Professional & scientific | 2018 |
| S & M Young LP | | 2006 |
| S & P Heating Ltd | Construction | 2007 |
| S & S Chemical Cleaning & Water Treatment Limited | Water & waste | 2000 |
| S P Newman | Construction | 2010 |
| S&A Heating & Plumbing Ltd | Construction | 2017 |
| S&P Property Group Ltd | Construction | 2026 |
| S.Collins Consultancy Limited | Construction | 2017 |
| S.D. Plastering Limited | Construction | 2002 |
| S.D. Watts Limited | Construction | 2007 |
| S.K.W. Property Services Ltd | Real estate | 2007 |
| S.P Fast Foods Ltd | Hospitality | 2022 |
| Sabatini Investments Limited | Real estate | 2006 |
| Sabrina HMO Limited | Real estate | 2026 |
| Safeharbor Healthcare Ltd | Health & social care | 2026 |
| Safety First Traffic Management Ltd | Construction | 2025 |
| Sail Consulting Limited | Information & communication | 2008 |
| Sail on Board Ltd | Administrative & support | 2016 |
| Sail Training International | Other services | 2003 |
| Sailing Britican Limited | Arts & recreation | 2019 |
| Sailtek Limited | Wholesale & retail | 2009 |
| Sailwithjoe Ltd. | Manufacturing | 2020 |
| Salecology AI Ltd | Professional & scientific | 2026 |
| Saleh Consulting (UK) Ltd | Professional & scientific | 2026 |
| Sales & Partners Limited | Wholesale & retail | 2026 |
| Salesbyfreya Ltd | Wholesale & retail | 2024 |
| Salfar Ltd | Wholesale & retail | 2022 |
| Salmon Electrical Engineering Ltd | Manufacturing | 2022 |
| Salmon Safety Services Limited | Education | 2007 |
| Sanders Ventures Limited | Professional & scientific | 2018 |
| Sandhu Supermarket Limited | Hospitality | 2011 |
| Sanford Properties Ltd | Real estate | 2023 |
| Sanie Restaurant Limited | Hospitality | 2025 |
| SAP Rental Properties Limited | Real estate | 2024 |
| Sarah Barrett Hairdressing Ltd | Other services | 2009 |
| Saupe Properties Ltd | Real estate | 2025 |
| Saville Court Management Company Limited | Households | 1992 |
| Sayan Curry Club Ltd | Hospitality | 2014 |
| Sbowling Ltd | Financial services | 2018 |
| SBT Hobbies & Autos Limited | Wholesale & retail | 2005 |
| SC Plumbers Ltd | Construction | 2014 |
| Schaff Partners LLP | | 2016 |
| SCJ Entertainment Ltd | Arts & recreation | 2008 |
| SCM International Limited | Professional & scientific | 2025 |
| Scomodo Ltd | Other services | 2019 |
| Scott Roberts (Carpets) Limited | Construction | 2002 |
| Sean.Linger Ltd | Manufacturing | 2018 |
| Search Party Recruitment Limited | Administrative & support | 2019 |
| Sebastion Consulting Ltd | Professional & scientific | 2025 |
| Secmee Ltd | Other services | 2024 |
| Secure Home Improvements Limited | Construction | 2008 |
| Sekules Consulting Ltd. | Information & communication | 2013 |
| Selden Masts Limited | Manufacturing | 1969 |
| Select Cards Ltd | Extraterritorial | 2009 |
| Sense & Sensorbility Ltd | Professional & scientific | 2025 |
| Senzak Medical Services Limited | Health & social care | 2024 |
| Serenity Aesthetics Clinic Ltd | Other services | 2019 |
| Serenity Nails and Beauty Limited | Other services | 2012 |
| Sermon Consulting Limited | Information & communication | 2007 |
| SET Sure Limited | Other services | 2020 |
| Seyi Attires Ltd | Manufacturing | 2022 |
| SGT Property Developments Limited | Real estate | 2018 |
| SHAKEPO12 Limited | Hospitality | 2022 |
| Shakes at Gosport Ltd | Hospitality | 2025 |
| Shamrock Pubs Ltd | Hospitality | 2026 |
| Shareholders Together Limited | Extraterritorial | 2026 |
| Sharples Music Limited | Professional & scientific | 2014 |
| Shaun Bulpitt Cleaning Services Ltd | Other services | 2002 |
| Sheehan Events Ltd | Hospitality | 2025 |
| Shekinah Vibe Ltd | Wholesale & retail | 2024 |
| Shepherd (Hospital Equipment) Limited | Wholesale & retail | 2000 |
| Shift IT Removals Limited | Administrative & support | 2011 |
| Shiny Smile Ltd | Health & social care | 2011 |
| SHJ Marine Ltd | Professional & scientific | 2023 |
| Shoe Deck Ltd | Wholesale & retail | 2012 |
| Shopafrods Limited | Wholesale & retail | 2025 |
| Showcreations Ltd | Arts & recreation | 2020 |
| Sicha Ltd | Real estate | 2022 |
| Sikania Ltd | Professional & scientific | 2017 |
| Silan Grill Ltd | Hospitality | 2018 |
| Silk Road Professionals UK Ltd | Information & communication | 2024 |
| Silver Palace Takeaway Ltd | Hospitality | 2015 |
| Simon Halliday Consultancy Ltd | Professional & scientific | 2025 |
| Simon Quays Properties Limited | Real estate | 2026 |
| Simon Reekie Carpentry Services Ltd | Construction | 2021 |
| Sirbo Ltd | Real estate | 2025 |
| Sisters Inn Arms Venues Limited | Hospitality | 2018 |
| Siteplan Southern Limited | Construction | 2003 |
| Sixiz Limited | Professional & scientific | 2017 |
| SJL Business Hub Ltd | Professional & scientific | 2024 |
| SJS Builders Limited | Construction | 2018 |
| SK Electrical & Mechanical Limited | Real estate | 2000 |
| SK Services (Southern) Limited | Construction | 2000 |
| Skandoor Ltd | Manufacturing | 2013 |
| Skillplace Group Ltd | Administrative & support | 2024 |
| Skirr Adventures Ltd | Other services | 1990 |