| Salko UK Limited | Construction | 2000 |
| Saltmarshe Consultancy Ltd | Administrative & support | 2015 |
| SAM Atkinson LLP | | 2010 |
| SAM Davey Motors and Maintenance Ltd | Wholesale & retail | 2025 |
| SAM Rollinson Limited | Professional & scientific | 2013 |
| Samudra Design Ltd | Wholesale & retail | 2024 |
| Sandbox Accounting Ltd | Professional & scientific | 2020 |
| Sanderson&Co Ltd | Real estate | 2025 |
| Sandpiper Bay Ltd | Hospitality | 2025 |
| Sandwood Kennels Limited | Agriculture & fishing | 2026 |
| Sara (DE) Ltd | Hospitality | 2024 |
| SAS Accounting for Aesthetics Limited | Professional & scientific | 2020 |
| Savanna Mcdermott Limited | Health & social care | 2022 |
| SC Mason Limited | Construction | 2025 |
| Scattered Audio Visual Limited | Wholesale & retail | 2020 |
| Scatterling Ltd | Hospitality | 2024 |
| SCF Fire Safety Limited | Professional & scientific | 2010 |
| Scoot - Let’S GET a Move on Ltd | Real estate | 2019 |
| Scott Frankland TM Ltd | Construction | 2025 |
| Screedtec UK Ltd | Construction | 2026 |
| Scutt Farming | Agriculture & fishing | 2006 |
| Scutt's Eggs Limited | Agriculture & fishing | 2025 |
| Sea-Haul Clearing Limited | | 1989 |
| Seanmite Global Link Limited | Wholesale & retail | 2024 |
| Seckler Transport Ltd | Transport & logistics | 2017 |
| Sector 7 Motorsport Limited | Wholesale & retail | 2025 |
| Segways Consultants Ltd | Professional & scientific | 2026 |
| Self Store Goole Ltd | Transport & logistics | 2021 |
| Sellbon Properties Limited | Real estate | 2023 |
| SEV Transport Ltd | Transport & logistics | 2016 |
| SH Transport Ltd | Transport & logistics | 2013 |
| Shaft Kaya Limited | Hospitality | 2025 |
| Shapla Express Ltd | Hospitality | 2026 |
| Shapla Goole Ltd | Hospitality | 2024 |
| Sharp EYE Detail Ltd | Wholesale & retail | 2020 |
| Shears Real Estate Ltd | Real estate | 2023 |
| Sheds UK Inc Ltd | Construction | 2023 |
| Shedshare Limited | Real estate | 2024 |
| Sherburn Property Limited | Real estate | 2022 |
| Sherburn Rubber Company Limited | Wholesale & retail | 1995 |
| Sherwood Restaurants Ltd | Hospitality | 2008 |
| Shfc Limited | Professional & scientific | 2012 |
| Shillings Capital Ltd | Real estate | 2023 |
| Shire Spaces Ltd | Real estate | 2017 |
| Shires Engineering Developments Limited | Manufacturing | 1999 |
| Shore Creative Ltd | Information & communication | 2004 |
| Shout Design and Print Ltd | Professional & scientific | 2021 |
| Showdown Music Limited | Professional & scientific | 2009 |
| Sib.Travel Ltd | Transport & logistics | 2024 |
| Siddicks Family Holdings Ltd | Financial services | 2026 |
| Siddicks RE Ltd | Real estate | 2026 |
| Sign & Display Solutions Limited | Wholesale & retail | 2013 |
| Signature Corp Ltd | Professional & scientific | 2017 |
| Signetext Limited | Manufacturing | 2002 |
| Silva Engineering Services Limited | Manufacturing | 2023 |
| Simon Gibson Transport Limited | Transport & logistics | 2002 |
| Simply Urban Cafe Ltd | Hospitality | 2019 |
| Simpson Accounting Services Limited | Professional & scientific | 2010 |
| SJP Haulage Ltd | Transport & logistics | 2025 |
| SJR Consultants Ltd | Professional & scientific | 2024 |
| SJS Developments (Yorkshire) Ltd | Construction | 2024 |
| Skelton Transport Ltd | Transport & logistics | 2014 |
| Skjgl Holdings Ltd | Financial services | 2023 |
| Smallwood Homes Limited | Other services | 2001 |
| Smart Score Data Limited | Information & communication | 2024 |
| SMK Electrical Limited | Construction | 2020 |
| SMS House Management Company Limited | Hospitality | 1994 |
| Snaith Carwash Ltd | Wholesale & retail | 2023 |
| Snaith Management (Irrigation) Limited | Water & waste | 1986 |
| Snaith Management (Roads) Limited | Real estate | 1986 |
| Snaith Management Ltd | Professional & scientific | 2024 |
| Snaith Solutions Ltd | Information & communication | 2015 |
| Snapshot Consulting Limited | Professional & scientific | 2022 |
| Snlb Ltd | Manufacturing | 2011 |
| Snoots Dog Grooming Training School Ltd | Education | 2026 |
| Softscape(Goole) Ltd | Transport & logistics | 2011 |
| Sopay Rides Hand Car Wash Ltd | Wholesale & retail | 2024 |
| Sophie Mort Photography Ltd | Professional & scientific | 2022 |
| South Lincs Cement Limited | Transport & logistics | 2023 |
| Southerton Investments Limited | Professional & scientific | 2001 |
| Southfork Innovations Limited | Manufacturing | 1997 |
| Spaldington Holdings Limited | Agriculture & fishing | 2013 |
| Spaldington Residents CIC | Other services | 2020 |
| Spark Accommodation Ltd | Hospitality | 2021 |
| Sparked Marketing Limited | Professional & scientific | 2026 |
| Sparks Electrical (North) Limited | Construction | 2022 |
| Spartan Risk Ltd | Professional & scientific | 2025 |
| Spatialevo Ltd | Information & communication | 2025 |
| Specialised Project Services Ltd | Construction | 2020 |
| Spectrum Quantity Surveying Ltd | Professional & scientific | 2024 |
| Spencer & Co Recruitment Limited | Administrative & support | 2026 |
| Spice Garden (Goole) Ltd | Administrative & support | 2014 |
| Spooners Services Ltd | Administrative & support | 2026 |
| Spotlight Cleaning Ltd | Administrative & support | 2025 |
| Spotlight Estates Ltd | Hospitality | 2024 |
| Spotlight Safety Ltd | Professional & scientific | 2024 |
| Spraying & Painting Specialists Limited | Construction | 2007 |
| Sprayless Scratch Repair UK Limited | Manufacturing | 2017 |
| Spring Clean Cleaning Services Ltd | Administrative & support | 2025 |
| SRA Tech Ltd | Information & communication | 2018 |