| Creative CAD & Media Services Limited | Professional & scientific | 2022 |
| Credence & Co UK Ltd | Real estate | 2023 |
| Crefoirt Ltd | Extraterritorial | 2024 |
| Crescent Supported Living Limited | Health & social care | 2018 |
| Cresta Original Expertise Ltd | Information & communication | 2025 |
| Crestfield Advisory Limited | Professional & scientific | 2026 |
| Crestwood Consulting Group Ltd | Information & communication | 2026 |
| Crew-Smith Construction Ltd | Construction | 2026 |
| Crimpcraft Limited | Wholesale & retail | 2023 |
| Crispy's Foods Ltd | Hospitality | 2020 |
| Crocodile Spirit Limited | Arts & recreation | 2006 |
| Croftmount I.T. Limited | Information & communication | 1999 |
| Crofton Investments Limited | Financial services | 2000 |
| Cromwell Estates (Glos) Limited | Real estate | 2015 |
| Cronos Express Limited | Transport & logistics | 2023 |
| Cross Country Environmental Limited | Administrative & support | 2009 |
| Cross Hands Garage Limited | Wholesale & retail | 2016 |
| Crosshaven Limited | Real estate | 2022 |
| Crossroads Care Gloucestershire Limited | Health & social care | 2002 |
| Crowndraws Ltd | Information & communication | 2026 |
| Crowned Elegance Limited | Wholesale & retail | 2015 |
| Crownhawk Limited | Real estate | 1999 |
| CRP Subsea Holdings Limited | Manufacturing | 2020 |
| CRP Subsea Limited | Manufacturing | 1978 |
| Cryptoshell Ltd | Extraterritorial | 2018 |
| Crystal Clean (SW) Ltd | Administrative & support | 2024 |
| Crystal Clear Gloucestershire Cleaning Services Ltd | Administrative & support | 2025 |
| Crystal Orbit Ltd | Wholesale & retail | 2022 |
| Crystal Point Cleaning Services Ltd | Administrative & support | 2025 |
| Crystal Twenty Four Limited | Wholesale & retail | 2026 |
| CS Badminton Club Ltd | Arts & recreation | 2023 |
| CS Harris Events Ltd | Arts & recreation | 2024 |
| CS Law Limited | Financial services | 2019 |
| CSR Comms Ltd | Information & communication | 2020 |
| Csrl Property Company Limited | Hospitality | 2018 |
| CT Contractors Ltd | Construction | 2020 |
| CTD Events Ltd | Arts & recreation | 2024 |
| Ctih Limited | Administrative & support | 2007 |
| Ctrl Male Image Ltd | Other services | 2024 |
| CUE Recruitment Ltd | Administrative & support | 2018 |
| Cuff Management Group Ltd | Real estate | 2021 |
| Cullimores MIX Limited | Construction | 1971 |
| Culturebreakfast Ltd | Professional & scientific | 2026 |
| Culver Construction Ltd | Construction | 2023 |
| Cuong Hung Pham Ltd | Other services | 2023 |
| Cuong Pham Ltd | Other services | 2017 |
| Cuong Thinh Phat Ltd | Other services | 2025 |
| Cuppacard Ltd | Information & communication | 2024 |
| Cura Inclusive Ltd | Health & social care | 2024 |
| Curatec Ltd | Wholesale & retail | 2026 |
| Cure Care Limited | Manufacturing | 2021 |
| Curry House Limited | Hospitality | 2018 |
| Curry National Ltd | Hospitality | 2025 |
| Cursed Flail Limited | Professional & scientific | 2024 |
| Curtain Call Limited | Arts & recreation | 2022 |
| Cutover Solutions Ltd | Information & communication | 2025 |
| CVF Rochdale Ltd | Wholesale & retail | 2017 |
| CW Aucamp Ltd | Wholesale & retail | 2025 |
| CWC MS Ltd | Information & communication | 2026 |
| Cwirek Ltd | Transport & logistics | 2021 |
| CWP Enterprises Ltd | Administrative & support | 2010 |
| CWP Estates Ltd | Real estate | 2013 |
| Cwsl Ltd | Wholesale & retail | 2004 |
| CY Associates (Shire) Ltd | Professional & scientific | 2015 |
| CY2 Group Limited | Financial services | 2025 |
| CY2 Limited | Information & communication | 2019 |
| CY2 Property Limited | Real estate | 2025 |
| Cyber Angels Limited | Information & communication | 2020 |
| Cyber Teko Ltd | Professional & scientific | 2020 |
| CYBER5 Internet Ltd | Manufacturing | 2018 |
| Cybernetic Software Systems Ltd | Information & communication | 2018 |
| Cygnus Alpha Events Limited | Administrative & support | 2017 |
| Cylern Ltd | Professional & scientific | 2020 |
| CYP 3 Ltd | Hospitality | 2023 |
| Czechland Limited | Wholesale & retail | 2006 |
| D & J Bars Ltd | Administrative & support | 2012 |
| D & J Light Freight Limited | Transport & logistics | 2018 |
| D & O Services Ltd | Construction | 2019 |
| D B Douglas Construction Ltd | Construction | 2014 |
| D Cooper Motor Repairs Ltd | Wholesale & retail | 2004 |
| D Dickinson Property Ltd | Households | 2024 |
| D G Welding (Gloucestershire) Ltd | Construction | 2014 |
| D J a Construction Consultants Ltd | Administrative & support | 2017 |
| D J Hunters Limited | Wholesale & retail | 2023 |
| D J Read Limited | Construction | 2016 |
| D Kent Fencing Ltd | Construction | 2018 |
| D N Doughty Holdings Limited | Real estate | 2023 |
| D Palmer Electrical Limited | Manufacturing | 2016 |
| D Perrins Cars Ltd | Wholesale & retail | 2019 |
| D R Eggleton (Developments) Ltd | Construction | 2003 |
| D R T Floor Screeding Specialists Limited | Construction | 2004 |
| D Taylor Roofing Ltd | Construction | 2017 |
| D&G Marian Ltd | Real estate | 2023 |
| D&J Property Developments & Management Ltd | Construction | 2025 |
| D&M Quality Cleaning Services Ltd | Administrative & support | 2023 |
| D'Abitot Solutions Ltd | Professional & scientific | 2015 |
| D. Sankey Limited | Administrative & support | 2013 |
| D.A. & D.D. Prout Ltd | Wholesale & retail | 2010 |
| D.B.D Sales & Services Ltd | Manufacturing | 2012 |
| D.H. Juggins Limited | Construction | 2002 |