| Providence Property Rental Ltd | Real estate | 2021 |
| QOC Hospitality Ltd | Hospitality | 2021 |
| R C Withers & SON Limited | Transport & logistics | 2001 |
| R D S Haulage (SW) Limited | Transport & logistics | 2013 |
| R L Clapp and Sons (Cheesemakers) Limited | Manufacturing | 1974 |
| R Watkins Property Maintenance Ltd | Construction | 2018 |
| R.J.Draper & Company,Limited | Manufacturing | 1941 |
| Ralph Bending Limited | Real estate | 2004 |
| RB Create Limited | Information & communication | 2009 |
| Real Life Drama Records Ltd | Information & communication | 2018 |
| Rebecca Unwin Holdings Ltd | Professional & scientific | 2021 |
| Rebex Limited | Health & social care | 2025 |
| Recycling Engineers Services Limited | Professional & scientific | 2004 |
| Red Breast Productions Ltd | Information & communication | 2016 |
| Red Brick Building Tenancy Services Ltd | Real estate | 2012 |
| Red Green Go Ltd | Administrative & support | 2018 |
| Red Spring Classics & Sports Ltd | Wholesale & retail | 2021 |
| Redacap Limited | Information & communication | 2012 |
| Redlands Computing Limited | Information & communication | 2008 |
| Rees-Davies Properties Limited | Real estate | 2001 |
| Reproduction Furniture Ltd | Manufacturing | 2024 |
| Reservoir View (Cheddar) Limited | Real estate | 2022 |
| Resource Accounting Limited | Professional & scientific | 1996 |
| Richard Lewis Limited | Construction | 2003 |
| ROB Jones Cars (Glastonbury) Ltd | Wholesale & retail | 2022 |
| Robanna Estate Control LLP | | 2005 |
| Robins Way Management Ltd | Real estate | 2021 |
| Rocks Drove Consortium Limited | Arts & recreation | 1999 |
| Root & Stone Construction Ltd | Construction | 2025 |
| Root & Stone Landscaping Ltd | Administrative & support | 2025 |
| Rosanna Mckaig Ltd | Administrative & support | 2023 |
| Rosewood Carpentry Limited | Construction | 2022 |
| Round Table Enterprises Limited | Hospitality | 2017 |
| Ruddle Financial Management Limited | Financial services | 2025 |
| Runbikesurf Ltd | Manufacturing | 2021 |
| S J Field Ltd. | Real estate | 2013 |
| S J Green Limited | Agriculture & fishing | 2002 |
| S Love Bricklayers Limited | Construction | 2021 |
| S-Line Engineering Limited | Professional & scientific | 2012 |
| Sacred Wild Wellbeing CIC | Health & social care | 2024 |
| Sanctioned Events Ltd | Hospitality | 2023 |
| Sanctuary Pools Ltd | Construction | 2021 |
| Sanctuary Privacy Ltd | Information & communication | 2026 |
| Sank Cat Ltd | Hospitality | 2022 |
| Sarah Datta Consulting Limited | Professional & scientific | 2020 |
| Sarah Petherick Ltd | Wholesale & retail | 2003 |
| SAS Plumbing & Maintenance Ltd | Construction | 2022 |
| SAS Welding Services Limited | Construction | 2017 |
| Satan's Gravy Productions Ltd | Manufacturing | 2026 |
| Sattvica Limited | Professional & scientific | 2013 |
| Scholars Gate (Glastonbury) Management Company Limited | Households | 2004 |
| Scott's Gardening Services Ltd | Administrative & support | 2025 |
| Scrumpy Events Limited | Hospitality | 2025 |
| Scrumpy Munchies Limited | Hospitality | 2025 |
| Sean Thurley Limited | Information & communication | 2018 |
| Selene Events Ltd | Arts & recreation | 2013 |
| Selwood Accounts and Tax Ltd | Professional & scientific | 2014 |
| Servicegym Ltd | Other services | 2025 |
| Sewtech Somerset Limited | Professional & scientific | 1988 |
| Shades and Characters Limited | Information & communication | 1987 |
| Shamanic Gathering UK CIC | Arts & recreation | 2015 |
| Sharif Catering Ltd | Hospitality | 2024 |
| SIA Taylor Ltd | Manufacturing | 2016 |
| Signature Property Enhancements Ltd | Construction | 2019 |
| Signature Vehicle Enhancements Ltd | Manufacturing | 2020 |
| Silver Birch Gardens Ltd | Administrative & support | 2013 |
| Silver Linings (Bristol) Ltd | Construction | 2017 |
| Silver Street (Glastonbury) Limited | Households | 1988 |
| Simple Financial Management Limited | Professional & scientific | 2014 |
| Simple Publishing Limited | Information & communication | 2006 |
| Simple Records Limited | Information & communication | 2002 |
| Sirius Quantum Technologies Ltd | Information & communication | 2025 |
| SJG Business Support Limited | Professional & scientific | 2003 |
| SJH Garage Services Limited | Wholesale & retail | 2011 |
| Sky Sports Limited | Manufacturing | 2002 |
| Slab House Property Ltd | Construction | 2022 |
| Sloth Data Solutions Ltd | Information & communication | 2021 |
| SMC Development (SW) Ltd | Construction | 2018 |
| Social Web Limited | Administrative & support | 2024 |
| Sole Function Podiatry Limited | Health & social care | 2022 |
| Solea Foundation | Education | 1987 |
| Solomon Software (UK) Ltd | Information & communication | 1996 |
| Somerset Football Association Limited | Arts & recreation | 1999 |
| Somerset Perfumery Ltd | Wholesale & retail | 2018 |
| Somerset Plastering Limited | Construction | 2009 |
| Somerset Silver Ltd | Wholesale & retail | 2023 |
| Somerset Staffing Ltd | Professional & scientific | 2021 |
| Songbird Naturals Limited | Wholesale & retail | 2006 |
| Souleia Ltd | Wholesale & retail | 2026 |
| Soulvibe App Ltd | Health & social care | 2024 |
| Southampton Bookkeeping Limited | Professional & scientific | 2008 |
| Southbay Productions Limited | Information & communication | 2013 |
| Sparks Warehousing Limited | Financial services | 2011 |
| Spenlow and Jorkins Ltd | Wholesale & retail | 2023 |
| SPT & M Ltd | Transport & logistics | 2018 |
| SRH Recruitment Limited | Administrative & support | 2018 |
| ST Benedicts Nursing Home Limited | Health & social care | 2016 |
| ST Cecilia Care Home Limited | Health & social care | 2016 |
| ST. Cuthberts Stables Management Limited | Households | 1986 |
| Stanley C Baker and Sons Limited | Construction | 2018 |