| Safety Integrity Solutions Ltd | Professional & scientific | 2021 |
| Safety Renaissance Limited | Public administration | 2024 |
| Saffron Social Care and Integrated Services Group Ltd | Health & social care | 2019 |
| Sage Flooring Ltd | Construction | 2022 |
| Sahasrakshi Services Ltd | Wholesale & retail | 2013 |
| Sai-Shyam Healthcare Ltd | Wholesale & retail | 2023 |
| Sailing International Trade Co., Limited | Wholesale & retail | 2023 |
| Sainivriti Consulting Limited | Professional & scientific | 2022 |
| Saint Investment & Development Limited | Real estate | 2019 |
| Saja Haulage Limited | Transport & logistics | 2023 |
| Saji John Properties Ltd | Real estate | 2023 |
| SAK Foods Ltd | Hospitality | 2025 |
| Sakriya Health Ltd | Education | 2025 |
| Salahm Limited | Real estate | 2021 |
| Salaris Limited | Information & communication | 2025 |
| Salisbury & Avon Gazette Ltd | Extraterritorial | 2022 |
| Salisbury Self Storage Ltd | Transport & logistics | 2023 |
| Salisbury Training Solutions Ltd | Construction | 2025 |
| Salisbury Window Cleaning Services Limited | Administrative & support | 2015 |
| Salmahumain Limited | Wholesale & retail | 2024 |
| Salsabeel Life Coaching Ltd | Health & social care | 2025 |
| Salute Rigging Services Limited | Construction | 2015 |
| SAM Haulage Limited | Transport & logistics | 2015 |
| SAM Lebeau Engineering Ltd | Construction | 2018 |
| Samad's Properties Limited | Real estate | 2024 |
| Samalyve Services Ltd | Construction | 2025 |
| Samananny Ltd | Health & social care | 2026 |
| Samaram & Co Ltd | Financial services | 2025 |
| Sambol Global (UK) Ltd | Professional & scientific | 1999 |
| Same Day Medical Ltd | Health & social care | 2024 |
| Samelal Limited | Wholesale & retail | 2026 |
| Sams Vegan Plate Ltd | Hospitality | 2025 |
| Samson Bespoke Construction Ltd | Construction | 2025 |
| Samuel Montagu FC Ltd | Other services | 2022 |
| Samuelson Services Limited | Information & communication | 2017 |
| SAN Lucas MRI Radiography and Sonography Solution Ltd | Health & social care | 2024 |
| Sanbeck Properties Limited | Real estate | 2021 |
| Sanctions Risk Advisory Ltd | Professional & scientific | 2026 |
| Sands Initiatives Ltd | Education | 2025 |
| Sandu Constructions London Ltd | Construction | 2019 |
| Sanncal Limited | Wholesale & retail | 2018 |
| Sansom & Strong Electrical Contractors Ltd | Construction | 2012 |
| Sansom Commercial Limited | Professional & scientific | 2017 |
| Santorini Savor of Gyors Ltd | Hospitality | 2025 |
| Sapphire Care (Kent) Limited | Health & social care | 2024 |
| Sarah Brown Holdings Ltd | Real estate | 2019 |
| Sarah Jayne Aesthetics Academy Ltd | Education | 2023 |
| Saraluca Properties Limited | Real estate | 2020 |
| Sarina T Stores Ltd | Wholesale & retail | 2025 |
| Sarps & Co Healthcare Ltd | Health & social care | 2020 |
| Sarum Life Sciences Limited | Professional & scientific | 2022 |
| SAS 96 Limited | Real estate | 2022 |
| SAS Driver Hire Limited | Transport & logistics | 2021 |
| SAS Investments Ltd | Real estate | 2019 |
| Satnam Property Ltd | Financial services | 2000 |
| Saved to Serve International Limited | Hospitality | 2023 |
| Savu Solution Ltd | Manufacturing | 2025 |
| Saxon Engineering (Medway) Limited | Manufacturing | 2010 |
| Saxon Surveyors Ltd | Professional & scientific | 2020 |
| SB Commercial Associates Ltd | Professional & scientific | 2026 |
| SB Roofing and Building Ltd | Construction | 2026 |
| Sbqs Services Limited | Professional & scientific | 2018 |
| SCA Cleaning Services Ltd | Administrative & support | 2026 |
| Scaffsafe Consultants Ltd | Public administration | 2019 |
| Scaffsheet Ltd | Construction | 2025 |
| School of African Languages Limited | Education | 2020 |
| Schooldxp Limited | Information & communication | 2025 |
| Schulze Gang Ltd | Arts & recreation | 2025 |
| Scll Consultancy Ltd | Construction | 2015 |
| Scooter Wizards Ltd | Manufacturing | 2026 |
| Scott Security Systems Ltd | Administrative & support | 2018 |
| SCS Consultancy Services Limited | Construction | 2023 |
| SCS Student Properties Limited | Real estate | 2020 |
| Sculpt PT Ltd | Extraterritorial | 2018 |
| SD Utility Services Ltd | Construction | 2026 |
| SDF Electrical Ltd | Construction | 2026 |
| SDT Consulting Limited | Other services | 2015 |
| Seafood and Grill Sensations Ltd | Hospitality | 2024 |
| SEAGULL82 Ltd | Transport & logistics | 2020 |
| Seamsa Ltd | Real estate | 2020 |
| Sean Colohan Roofing Ltd | Construction | 2025 |
| Seanars Ltd | Hospitality | 2023 |
| Search Financial Limited | Administrative & support | 2005 |
| Searui International Limited | Manufacturing | 2016 |
| Seasons Heating & Aircon Ltd | Construction | 2012 |
| Seaton Court (Devon) Limited | Real estate | 2005 |
| SEB (UK) Fluid Controls Holdings Ltd | Manufacturing | 2019 |
| SEC Supplies & Fixings Ltd | Wholesale & retail | 2013 |
| Securise Limited | Construction | 2021 |
| Sedley Close Residents Company Limited | Households | 1976 |
| Sedx Ltd | Education | 2023 |
| Seeme Cycle Limited | Wholesale & retail | 2024 |
| Sehjal Supermarket Limited | Wholesale & retail | 2019 |
| Sekai Recruitment Ltd | Administrative & support | 2025 |
| Selfe Services Ltd | Professional & scientific | 2018 |
| Selfe Trading Ltd | Financial services | 2021 |
| Selor Transport Limited | Transport & logistics | 1999 |
| Selor Transport Logistics Limited | Transport & logistics | 2021 |
| Semnaya Limited | Construction | 2020 |
| Semoza Holdings Ltd | Administrative & support | 2024 |