| Erebor Wealth Ltd | Financial services | 2020 |
| Erebus Holdings Ltd | Other services | 2025 |
| Ergo Evolve Ltd | Wholesale & retail | 2020 |
| Eric Tcoms Ltd | Wholesale & retail | 2024 |
| Erimus Consultancy Services Ltd | Professional & scientific | 2016 |
| Eriss Limited | Professional & scientific | 2013 |
| ERM Marine Repairs Limited | Administrative & support | 2017 |
| Ermo Developments Limited | Other services | 2017 |
| Ernesther Ltd | Real estate | 2024 |
| Ernt Holdings Ltd | Manufacturing | 2025 |
| Erobik Ltd | Water & waste | 2018 |
| Eros Lowfell Ltd | Hospitality | 2026 |
| Errigal Tunnelling & Civil Engineering Ltd | Construction | 2024 |
| ES Property Ltd | Real estate | 2018 |
| ESE Lumos Ltd | Wholesale & retail | 2025 |
| Espoir Medical Aesthetics Training Ltd | Other services | 2025 |
| Esrog Limited | Hospitality | 2009 |
| Esse Essentialz Limited | Wholesale & retail | 2024 |
| Estate Capital Limited | Financial services | 2014 |
| Estate Homes Northumberland Ltd | Real estate | 2006 |
| Etechie Ltd | Information & communication | 2024 |
| Ethan Medical Services Ltd | Health & social care | 2025 |
| Ethan Phillips Ltd | Wholesale & retail | 2024 |
| Etherium Space Design Ltd | Professional & scientific | 2021 |
| Ethniq Collective Ltd | Wholesale & retail | 2023 |
| EU Business Services Limited | Transport & logistics | 2020 |
| Eureka Golf Limited | Wholesale & retail | 2010 |
| Euro Fire & Security Ltd | Administrative & support | 2023 |
| Euro Foods (GB) Limited | Manufacturing | 2005 |
| Euro Property Management Ltd | Construction | 2005 |
| Euromarket Wholesale Limited | Wholesale & retail | 1995 |
| Europa Roofing Limited | Construction | 2020 |
| European Circus Ltd | Arts & recreation | 2009 |
| European Endo Learning Academy Limited | Education | 2025 |
| European Vape Distribution Ltd | Wholesale & retail | 2019 |
| Eurova Ltd | Administrative & support | 2022 |
| Eurovent Hygiene Services Limited | Administrative & support | 2014 |
| Eurovent LEV Services Ltd | Administrative & support | 2023 |
| Eurovent Purifying Systems UK Limited | Administrative & support | 2006 |
| Euyy North West Ltd | Health & social care | 2023 |
| Event Colour Ltd | Wholesale & retail | 2013 |
| Ever 1855 Limited | Administrative & support | 2002 |
| Ever Adaptive Performance Ltd | Health & social care | 2021 |
| Ever Adaptive Training C.I.C. | Extraterritorial | 2024 |
| Ever Ready Apartments Limited | Hospitality | 2025 |
| Everbright Finance (UK) Ltd | Financial services | 2018 |
| Everdurance Ltd | Wholesale & retail | 2020 |
| Evergreen Salon (LOW Fell) Ltd | Other services | 2022 |
| Everready Cleaners Limited | Administrative & support | 2024 |
| Every Last Detail Events Limited | Other services | 2022 |
| Every Last Detail Limited | Administrative & support | 2021 |
| Everyday Elite Coaching Ltd | Arts & recreation | 2024 |
| Everything Lighting Limited | Wholesale & retail | 2024 |
| Eves Emporium Limited | Wholesale & retail | 2020 |
| EVM Trade Ltd | Wholesale & retail | 2017 |
| Evnt Inspirations Ltd | Hospitality | 2024 |
| Evolution (North East) Limited | Other services | 2003 |
| Evolution Bathrooms North East Ltd | Construction | 2026 |
| Evolution Home Maintenance Ltd | Construction | 2021 |
| Evolution Management Solutions Ltd | Administrative & support | 2018 |
| Evolve Therapy and Coaching UK Limited | Financial services | 2021 |
| EW (NE) Limited | Construction | 2025 |
| Exaltis Solutions Ltd | Administrative & support | 2017 |
| Excalibur Scaffolding North East Limited | Construction | 2023 |
| Excel Accounts FS Ltd | Professional & scientific | 2023 |
| Excel EMS LLP | | 2019 |
| Excellent Voyage Ltd | Wholesale & retail | 2025 |
| Excello Limited | Transport & logistics | 2005 |
| Excite Group Ltd | Wholesale & retail | 2022 |
| Exclusive Care Facilities Ltd | Construction | 2024 |
| Exclusive Care Group Ltd | Health & social care | 2015 |
| Exelvia Ltd | Professional & scientific | 2025 |
| Exmet Investment Limited | Real estate | 2008 |
| Experience Driving Limited | Education | 2002 |
| Experience Driving School Limited | Education | 2022 |
| Exponus Group Ltd | Education | 2021 |
| Exportpadi Limited | Financial services | 2025 |
| Express Engineering (Aerospace) Limited | Manufacturing | 2013 |
| Express Engineering (Fabrications) Limited | Manufacturing | 2023 |
| Express Engineering (Gateshead) Limited | Manufacturing | 1978 |
| Express Engineering (Group) Limited | Financial services | 2013 |
| Express Engineering (Holdings) Limited | Financial services | 2002 |
| Express Engineering (Industrial Products) Limited | Manufacturing | 2013 |
| Express Engineering Group Holdings Limited | Extraterritorial | 2025 |
| Express Garage Limited | Wholesale & retail | 2006 |
| Extension HR Limited | Administrative & support | 2011 |
| Extensive Holiday Solutions Ltd | Other services | 2024 |
| Extreme Health & Beauty Limited | Wholesale & retail | 2014 |
| Eyes Direct Limited | Health & social care | 2000 |
| F & a Housing Ltd | Real estate | 2014 |
| F & I Holdings Ltd | Financial services | 2016 |
| F Elliott Ltd | Real estate | 2024 |
| F H Kaufman Properties Ltd | Real estate | 2019 |
| F&I Management Limited | Administrative & support | 2003 |
| F. Newsome & SON Limited | Extraterritorial | 1991 |
| F.C. Business Operations Ltd | Extraterritorial | 1979 |
| F.E.S. Group (NE) Limited | Construction | 2016 |
| F.Handcock & Sons Limited | Wholesale & retail | 1956 |
| F1PCD Limited | Manufacturing | 2008 |
| FAB This Limited Limited | Manufacturing | 2025 |