| CP Lighting Centre Limited | Wholesale & retail | 2011 |
| CP North East Maintenance Limited | Administrative & support | 2015 |
| Cpma Limited | Professional & scientific | 1997 |
| Cpom Property Ltd | Real estate | 2024 |
| CPT Telecom Limited | Information & communication | 2015 |
| Crabco Limited | Manufacturing | 2007 |
| Crabtree of Gateshead (Holdings) Limited | Manufacturing | 2005 |
| Crabtree of Gateshead Limited | Manufacturing | 2002 |
| Crafting Hope CIC | Professional & scientific | 2024 |
| Crag Estates Limited | Real estate | 2015 |
| Craggs Automotive (C.A.R.S) Limited | Wholesale & retail | 2026 |
| Craggs Automotive Repair & Service (C.A.R.S) Limited | Wholesale & retail | 2026 |
| Craig Fairley Limited | Construction | 2025 |
| Craig Giles Wealth Management Ltd | Financial services | 2020 |
| Craig's TIP Top Tick Tocks Ltd | Manufacturing | 2025 |
| Crandus (Contractors) Limited | Real estate | 1956 |
| Cranston Joinery Limited | Construction | 2024 |
| Crawford Electrical Limited | Construction | 2012 |
| CRB Specialist Construction Ltd | Construction | 2026 |
| CRC Estates Ltd | Real estate | 2025 |
| Creativ Technologies Ltd | Information & communication | 2024 |
| Creative Cutting Properties Limited | Real estate | 2013 |
| Creative Install Limited | Construction | 2008 |
| Creative Pop-Ups Ltd | Hospitality | 2022 |
| Creatorsagency Ltd | Professional & scientific | 2026 |
| Cree's Energy Ltd | Construction | 2022 |
| Creme DE LA Creme Estates Ltd | Extraterritorial | 2011 |
| Cresswell Home Farm (Management Company) Limited | Real estate | 2016 |
| Crewkerne Dent and Implant Centre Ltd | Health & social care | 2023 |
| CRF Investments Ltd | Extraterritorial | 2010 |
| Crichton Wills, Trusts and Probate (North East) Limited | Professional & scientific | 2013 |
| Crick Link Limited | Administrative & support | 2022 |
| Crispr Pharmaceutical Company Ltd | Wholesale & retail | 2024 |
| Criterion Interior Solutions Limited | Construction | 2013 |
| CRK Consultancy Ltd | Wholesale & retail | 2019 |
| Crlo Ltd | Real estate | 2026 |
| CRN Joinery Ltd | Construction | 2015 |
| Croftkirk Corporation Ltd | Administrative & support | 2009 |
| Croftridge Properties Limited | Real estate | 2024 |
| Croftridge Property LLP | | 2025 |
| Crossco (1411) Limited | Extraterritorial | 1984 |
| Crossco (173) | Extraterritorial | 1995 |
| Crossco N0.3 Unlimited | Professional & scientific | 2007 |
| Crossco NO. 4 Unlimited | Professional & scientific | 2007 |
| Crothers and Sons Limited | Hospitality | 2004 |
| Crown and Ivory Ltd | Health & social care | 2025 |
| Crown Basket Estates Ltd | Real estate | 2026 |
| Crowncare Group Limited | Health & social care | 2018 |
| Crowne Events Ltd | Real estate | 2023 |
| Crowntree Products Limited | Wholesale & retail | 2003 |
| Crowther Lodge Motor Company Limited | Wholesale & retail | 2013 |
| Crusoes Tynemouth Limited | Hospitality | 2024 |
| CRV 2024 Ltd | Health & social care | 2024 |
| CS Health Limited | Health & social care | 2017 |
| CS Motor Engineering Limited | Wholesale & retail | 2015 |
| Cseh Ltd | Health & social care | 2014 |
| CST Vehicle Detailing Ltd | Wholesale & retail | 2024 |
| CST Vehicle Solutions Ltd | Wholesale & retail | 2024 |
| CT GAS & Heating Ltd | Construction | 2022 |
| CT Welding Ltd | Manufacturing | 2026 |
| Ctrl Hub Limited | Information & communication | 2015 |
| Cuepoint Creative Learning CIC | Education | 2026 |
| Cuepoint Learning Ltd | Education | 2025 |
| Cuepos Ltd | Information & communication | 2025 |
| Cullertony Limited | Wholesale & retail | 2025 |
| Cultural Freelancers CIC | Arts & recreation | 2020 |
| Cumbrian Dreams Ltd | Real estate | 2021 |
| Cumbrian Dreams PM Ltd | Administrative & support | 2023 |
| Cumbrian Retreats Limited | Real estate | 2026 |
| Cumbrian Spas Ltd | Other services | 2023 |
| Cupa Roofing Limited | Construction | 2019 |
| Curry and Peas Ltd | Hospitality | 2024 |
| Curry Garden Coatsworth Road Limited | Hospitality | 2023 |
| Curry HUT NE Ltd | Hospitality | 2024 |
| Curtain Charisma Ltd | Wholesale & retail | 2020 |
| Custom Eco Pack Ltd | Manufacturing | 2025 |
| Custom LED Limited | Wholesale & retail | 2013 |
| Custom Tint Ltd | Wholesale & retail | 2003 |
| CUT Above Aesthetics Ltd | Other services | 2025 |
| CVC Engineering Limited | Construction | 2015 |
| CW Fabrication Services Ltd | Other services | 2016 |
| CW GBP Limited | Information & communication | 2025 |
| CXH Engineering Limited | Professional & scientific | 2026 |
| CY & M Kaufman Limited | Real estate | 2017 |
| Cyber Governance Ltd | Information & communication | 2014 |
| Cyberinova Limited | Information & communication | 2023 |
| Cyberlytica Limited | Information & communication | 2025 |
| Cynegy Limited | Information & communication | 2025 |
| Czyz Investment Ltd | Real estate | 2021 |
| Czyz Ltd | Health & social care | 2019 |
| D & D North East Properties Ltd | Real estate | 2012 |
| D & L Appliances & Plumbing Services Ltd | Construction | 2019 |
| D & M Brickwork & Repointing NE Limited | Construction | 2025 |
| D a G Financial Ltd | Financial services | 2006 |
| D a Properties (Northern) Ltd | Real estate | 2008 |
| D and L Distribution Services Ltd | Transport & logistics | 2023 |
| D and S Structural Engineers Ltd | Professional & scientific | 2024 |
| D Angel Holdings Ltd | Professional & scientific | 2026 |
| D B Property Group ( N E ) Ltd | Construction | 2022 |
| D Berry (Gateshead) Limited | Health & social care | 2011 |