| Sltk Ltd | Wholesale & retail | 2025 |
| Slumgothic Limited | Arts & recreation | 2006 |
| SM & LM Anderson Limited | Agriculture & fishing | 2012 |
| Smaller Electrical Projects Ltd | Professional & scientific | 2025 |
| Smart Construction RO Ltd | Construction | 2024 |
| Smartphone Guys Ltd | Wholesale & retail | 2020 |
| Smiffys II Ltd | Wholesale & retail | 2024 |
| Smile Data Security Limited | Information & communication | 2015 |
| Smith & Johnson (Keighley) Limited | Manufacturing | 1993 |
| Smithinns Limited | Hospitality | 2009 |
| Smyth.Victoria Ltd | Other services | 2017 |
| Soban Brewing Co Ltd | Wholesale & retail | 2025 |
| Social Value Engine Limited | Information & communication | 2022 |
| Solar and Power Solutions Ltd | Construction | 2021 |
| Solar Team (UK) Ltd | Construction | 2011 |
| Sold Sold Sold Ltd | Wholesale & retail | 2025 |
| Soltat Limited | Other services | 2023 |
| SON JAY Holdings Ltd | Financial services | 2024 |
| Sothy Limited | Real estate | 2024 |
| Sound Control Limited | Other services | 2024 |
| Sound in Control Limited | Wholesale & retail | 2021 |
| Southdene Residential Ltd | Real estate | 2023 |
| Sparkacus Limited | Construction | 2015 |
| Special Place Property Investments Ltd | Real estate | 2025 |
| Spencera Consulting Ltd | Administrative & support | 2014 |
| SPH Practitioner Ltd | Other services | 2022 |
| Spiderline Logistics Limited | Transport & logistics | 2019 |
| SPL Accounting Ltd | Administrative & support | 2011 |
| Spoon Media Limited | Information & communication | 2006 |
| Spraying by Numbers Ltd | Construction | 2018 |
| Sprengstoff Marketing Limited | Professional & scientific | 2024 |
| Springcroft Consulting Limited | Other services | 2022 |
| Squeakygem Limited | Other services | 2023 |
| SRL Welding Ltd | Manufacturing | 2020 |
| SRS Vehicle Security Ltd | Manufacturing | 2019 |
| Ssell Ltd | Wholesale & retail | 2025 |
| SSL (Lincolnshire) Ltd | Other services | 2019 |
| ST Andrews (MPS) Limited | Health & social care | 2008 |
| Stacy Keast Limited | Other services | 2024 |
| Stage Digital Ltd | Professional & scientific | 2015 |
| Stallard Kane Associates Limited | Administrative & support | 2002 |
| Stallard Kane Group Limited | Financial services | 2021 |
| Stallions Direct Limited | Agriculture & fishing | 2021 |
| Standard Nutrafoods Limited | Manufacturing | 2017 |
| Stanfirm Limited | Construction | 2011 |
| Staniforth Limited | Information & communication | 2015 |
| Stanwayn Limited | Construction | 2011 |
| Statutory Equipment Inspection Solutions Ltd | Professional & scientific | 2025 |
| Stdc Ltd | Information & communication | 2009 |
| Steel Town Scaffolding Ltd | Construction | 2022 |
| Steph and Eddie's Taxi Ltd | Transport & logistics | 2025 |
| Steve Brady Developments Limited | Construction | 2004 |
| Stilecroft (MPS) Limited | Health & social care | 2007 |
| Stonecastle Improvements Limited | Construction | 2005 |
| Stoneholme Capital Limited | Agriculture & fishing | 2021 |
| Stoneridge Farm Ltd | Agriculture & fishing | 2025 |
| Stortec Engineering Limited | Manufacturing | 2018 |
| Stretch Fit Pilates & Therapy Ltd | Arts & recreation | 2020 |
| Stride Safety Ltd | Professional & scientific | 2012 |
| Stronger Routes CIC | Health & social care | 2025 |
| STS Commercials T/A STS Commercials Ltd | Wholesale & retail | 2018 |
| Stur Limited | Administrative & support | 2025 |
| Sturton by Stow Youth Club Limited | Arts & recreation | 2012 |
| Style Lounge Blyton Limited | Other services | 2019 |
| Sudari Aesthetics Limited | Other services | 2017 |
| Sufian Cusine Limited | Hospitality | 2020 |
| Sultpro Limited | Information & communication | 2015 |
| Sumit Construction Consultancy Ltd | Professional & scientific | 2024 |
| Summitstone Adventures Ltd | Administrative & support | 2025 |
| Sunflower Park Ltd | Agriculture & fishing | 2024 |
| Supplybase Solutions Ltd | Wholesale & retail | 2009 |
| SUPPORT2ENHANCE Limited | Education | 2026 |
| Supported Environments Limited | Construction | 2014 |
| Surespray Limited | Other services | 2024 |
| Surestaff Lincs. Limited | Administrative & support | 2008 |
| Surestay Properties Ltd | Construction | 2022 |
| Sutton Building Services Ltd | Construction | 2015 |
| Svald Ltd | Administrative & support | 2025 |
| Swan Sales and Lettings Limited | Real estate | 2019 |
| Swayne Professional Services Ltd | Information & communication | 2017 |
| SWC Construction Ltd | Construction | 2023 |
| Swift Deer Limited | Health & social care | 2024 |
| Sylvia's Café Ltd | Hospitality | 2025 |
| Symply Accounts Limited | Professional & scientific | 2014 |
| T & G Property Investment Limited | Real estate | 2025 |
| T and N Solutions Ltd | Construction | 2026 |
| T Green Plumbing & Heating Ltd | Construction | 2018 |
| T H Forington & SON Limited | Agriculture & fishing | 2004 |
| T H Parcs Ltd | Hospitality | 2018 |
| T M L Sales Limited | Hospitality | 2003 |
| T W Laming & SON Ltd | Agriculture & fishing | 2014 |
| T. P. M Plumbing & Heating Limited | Construction | 2017 |
| T.B. Johns Limited | Construction | 1997 |
| Tall Oaks Academy Trust Ltd | Education | 2013 |
| TAN Lounge EG Limited | Other services | 2023 |
| TAN MAN Ltd | Other services | 2017 |
| Tanglo Limited | Other services | 2009 |
| Tansad Ltd | Health & social care | 2018 |
| Tayfash Ltd | Manufacturing | 2025 |
| Taylors Management Services Limited | Administrative & support | 2017 |