| Saxon Garden Services Limited | Administrative & support | 2026 |
| Saxon Tree Specialists Limited | Administrative & support | 2022 |
| Second Sight Design Limited | Administrative & support | 2007 |
| Secure Buy to Lets Ltd | Real estate | 2025 |
| Serversgb Ltd | Wholesale & retail | 2020 |
| Shendi Limited | Health & social care | 2022 |
| Shove Media Limited | Administrative & support | 2006 |
| SIX Elements Fitness Ltd | Arts & recreation | 2024 |
| Skin Formby Limited | Health & social care | 2023 |
| Skyetech Automation Ltd | Manufacturing | 2019 |
| Skyetechautomation &Engineering Ltd | Professional & scientific | 2024 |
| Snook Architects Limited | Professional & scientific | 2006 |
| Snook Construction Limited | Construction | 2016 |
| Soccer Suites Limited | Hospitality | 2024 |
| Soda Executive Travel Limited | Transport & logistics | 2023 |
| Solada Care Group Limited | Health & social care | 2025 |
| Squirrels Driving School Ltd | Administrative & support | 2023 |
| Stanley Ferro Bathrooms Limited | Construction | 2025 |
| Stephenson Pre-Construction Services Ltd | Construction | 2019 |
| Steve Cullen Plumbing & DIY Supplies Limited | Wholesale & retail | 2010 |
| Superpower Coaching Limited | Education | 2020 |
| T&L Renovations Ltd | Real estate | 2025 |
| T.C.G. Electrical Ltd | Construction | 2023 |
| Talent Quest Consultancy Limited | Arts & recreation | 2025 |
| Taylor Stopforth Limited | Professional & scientific | 2024 |
| TCM Limited | Professional & scientific | 2005 |
| Telesis Health Limited | Health & social care | 2014 |
| THE Belvedere CSH Property Limited | Hospitality | 2014 |
| THE Custom Shop Limited | Wholesale & retail | 2017 |
| THE Hearth Network CIC | Professional & scientific | 2024 |
| THE Little Toilet Company Limited | Administrative & support | 2022 |
| THE Next 9 Academy Limited | Education | 2025 |
| THE Nook (NW) Limited | Administrative & support | 2026 |
| THE Style Collective Widnes Ltd | Wholesale & retail | 2025 |
| THE Style Room (Formby) Ltd | Other services | 2012 |
| THE Vintage Clothing Company Limited | Wholesale & retail | 2001 |
| THE Wall Top Alarm Company Limited | Administrative & support | 2010 |
| Tjhinds Limited | Arts & recreation | 2026 |
| TML Combat and Fitness Limited | Other services | 2016 |
| Tmnw Solutions Ltd | Wholesale & retail | 2024 |
| TOM Owens Ltd | Education | 2018 |
| Total Timber (Formby) Limited | Wholesale & retail | 2006 |
| Tower Heating Ltd. | Construction | 2004 |
| Towry Logistics Limited | Transport & logistics | 2026 |
| Travel Service Direct Limited | Wholesale & retail | 2009 |
| Turner Resourcing Limited | Administrative & support | 2007 |
| Turners Heating & Plumbing Ltd | Construction | 2025 |
| Unit 54 S&C Limited | Arts & recreation | 2024 |
| V & R Accountancy Services Limited | Professional & scientific | 2019 |
| V & R Holdings Limited | Financial services | 2023 |
| Vanillaonline.Co.Uk Ltd | Wholesale & retail | 2025 |
| VB Consult Limited | Professional & scientific | 2024 |
| Venue Colour Limited | Other services | 2023 |
| Venue Hair Ltd | Other services | 2018 |
| Venue Vision Ltd | Information & communication | 2003 |
| Verinder & Associates Wealth Management Limited | Administrative & support | 2008 |
| Verismart North West Limited | Other services | 2015 |
| Versatile Plant Ltd | Administrative & support | 1987 |
| Vincent Corporation Ltd | Information & communication | 2019 |
| Vintage Thyme Catering & Events Limited | Hospitality | 2024 |
| VLP (NW) Limited | Real estate | 1989 |
| Vocatus Limited | Hospitality | 2023 |
| Voicecentreai Ltd | Information & communication | 2025 |
| Warren Farm Agri Ltd | Agriculture & fishing | 2026 |
| Waterloo House Property Management Limited | Households | 2026 |
| West Coast Coffee Limited | Manufacturing | 2022 |
| West Lancs K9 Ltd | Other services | 2024 |
| Whiteside Building Design Limited | Professional & scientific | 2021 |
| WN Evans Contractors Ltd | Administrative & support | 2025 |
| Woodvale Aircraft Owners Limited | Transport & logistics | 1997 |
| Woodvale Pilots Association Limited | Other services | 1998 |
| WRR Property Developments Limited | Real estate | 2023 |
| Wulff Kuchen Limited | Construction | 2024 |