| Screedpro Flooring Systems Ltd | Construction | 2018 |
| Sdaniels Solutions Ltd | Administrative & support | 2015 |
| Sdrwp Holdings Ltd | Financial services | 2024 |
| SDS Talent Limited | Administrative & support | 2024 |
| SDT Management Consultancy Ltd | Wholesale & retail | 2022 |
| SE Networking Ltd | Administrative & support | 2026 |
| Sea Painting and Decorating Limited | Construction | 2026 |
| Sebelec Limited | Professional & scientific | 2012 |
| Secpa Ltd | Health & social care | 2025 |
| Secret Coast Songwriters Ltd | Administrative & support | 2021 |
| Secure Transportation Ltd | Administrative & support | 2010 |
| Securevault.Life Ltd | Information & communication | 2025 |
| Security and Surveillance Ltd. | Manufacturing | 1998 |
| Sedcare LP | | 2022 |
| Seed Fund (Carry Partner) Limited Partnership | | 2007 |
| Seedl Employee Holdings Ltd | Professional & scientific | 2023 |
| Seedl Group Ltd | Professional & scientific | 2020 |
| Seekers Travel Limited | Transport & logistics | 2020 |
| Sefm General Partner Limited | Financial services | 2007 |
| SEL Properties Ltd | Real estate | 2025 |
| Selbon Property Services Limited | Real estate | 2019 |
| Senf Ltd | Professional & scientific | 2022 |
| Sensa Personal Care Limited | Manufacturing | 2013 |
| Sensato Services Limited | Information & communication | 2023 |
| September Comms Ltd | Professional & scientific | 2022 |
| Seriestech Solutions Ltd | Information & communication | 2013 |
| Serverbright Ltd | Information & communication | 2025 |
| Service Machinery Limited | Wholesale & retail | 2007 |
| Servoclear Ltd | Administrative & support | 2011 |
| Seven Inn Limited | Hospitality | 2006 |
| Sew-Works Ltd | Wholesale & retail | 2011 |
| Sewer Sealing Services Limited | Water & waste | 2000 |
| SFI Electrical Limited | Construction | 2008 |
| Sg&T Limited | Transport & logistics | 2000 |
| Shapes Design Limited | Professional & scientific | 2003 |
| Sharepoint PMO Limited | Information & communication | 2014 |
| Sharp Landscapes & Garden Services Limited | Administrative & support | 2015 |
| SHC Studio 3 Ltd | Other services | 2025 |
| Sheri Moreira Ltd | Professional & scientific | 2019 |
| Sherlocks Homes Ltd | Real estate | 2021 |
| Shihuahuaco Ltd | Professional & scientific | 2024 |
| Shiny Bolts Ltd | Wholesale & retail | 2020 |
| Shipton Wealth Limited | Financial services | 2017 |
| Shiv Prisha Properties Limited | Real estate | 2019 |
| Shiv Solutions Limited | Information & communication | 2012 |
| Shortheath Road Management Company Limited | Households | 2003 |
| Showcase Pictures Limited | Information & communication | 2008 |
| Shrestha & Gurung Care Ltd | Financial services | 2023 |
| Shubharambh Limited | Wholesale & retail | 2025 |
| Shuffle Tunes Limited | Arts & recreation | 2013 |
| Shunmei Consultants Ltd | Professional & scientific | 2025 |
| Shyam Shrestha & Co Accountants Limited | Professional & scientific | 2022 |
| Sign Easy Limited | Manufacturing | 1989 |
| Signwright Limited | Administrative & support | 2011 |
| Silk Hair Collective Ltd | Other services | 2025 |
| Silver Branch Limited | Administrative & support | 2016 |
| Silverlink Ltd | Real estate | 2017 |
| Simple Solutions (Business) Consultancy Ltd. | Professional & scientific | 2012 |
| Simply Billing Limited | Administrative & support | 2014 |
| Simply Quote Comparison Ltd | Other services | 2023 |
| Simurgh Productions Ltd | Professional & scientific | 2012 |
| Sinclair Trophies Limited | Administrative & support | 2020 |
| Single Frame Ltd | Information & communication | 2016 |
| Sivlink Ltd | Information & communication | 2018 |
| SJF Global Limited | Administrative & support | 2012 |
| SJR Financials Ltd | Professional & scientific | 2023 |
| SJS Waste Management Limited | Water & waste | 2026 |
| Sketchd Studio Limited | Professional & scientific | 2023 |
| SKI Famille Limited | Administrative & support | 1987 |
| SKI Vertigo Limited | Administrative & support | 2020 |
| Skinco Ltd | Wholesale & retail | 2019 |
| Skitsko Ltd | Construction | 2020 |
| Skyelectric Solutions Limited | Energy | 2025 |
| Skyline Heating and Plumbing Ltd | Construction | 2015 |
| Skysphere Ltd | Professional & scientific | 2024 |
| Sleek Accommodation Solutions Ltd | Hospitality | 2026 |
| SLR Infosec Limited | Information & communication | 2009 |
| SM River Limited | Professional & scientific | 2010 |
| Smart Furniture Fitting Ltd | Construction | 2020 |
| Smart Future Hvac Ltd | Professional & scientific | 2023 |
| Smart Step Recruitment Ltd | Administrative & support | 2017 |
| Smartr Sciences Ltd | Professional & scientific | 2025 |
| Smashcash Ltd | Professional & scientific | 2021 |
| SMB Foods Limited | Hospitality | 2018 |
| Smiths Garden Services Limited | Administrative & support | 1999 |
| Smiths of Fleet Limited | Wholesale & retail | 1991 |
| SMS Accounting Ltd | Professional & scientific | 1994 |
| SN Electrical Ltd | Construction | 2006 |
| Snap Marketing Group Limited | Professional & scientific | 2020 |
| Social Networking Group Ltd | Other services | 2024 |
| Sodha & Company Limited | Financial services | 2012 |
| Sodha Enterprises Limited | Financial services | 2004 |
| Solas Dental Supplies Ltd | Wholesale & retail | 2025 |
| Solo Bookkeeping Services Ltd | Professional & scientific | 2014 |
| Solution Acuity Services Limited | Professional & scientific | 2021 |
| Solve IT Systems Limited | Information & communication | 2005 |
| Somnusbreathing Ltd | Wholesale & retail | 2025 |
| Soni Corporation Limited | Information & communication | 2007 |
| Sonuachar Limited | Professional & scientific | 2015 |
| Sorted Healthcare Ltd | Administrative & support | 2020 |