| Pizzalicious Extra Limited | Hospitality | 2022 |
| Planning Essentials Ltd | Professional & scientific | 2024 |
| Plessey Orchard Ltd | Hospitality | 2024 |
| Poultry Panels Ltd | Manufacturing | 2018 |
| Power Counsel Consulting Ltd | Information & communication | 2024 |
| Propercleanwindows Ltd | Administrative & support | 2025 |
| Property North East Limited | Extraterritorial | 2009 |
| PS Utility Services Limited | Construction | 2019 |
| PTM Investments (NE) Ltd | Professional & scientific | 2024 |
| Q Properties Group Limited | Households | 2019 |
| Quality Hydraulics Limited | Wholesale & retail | 1999 |
| Quick Pick General Store Ltd | Wholesale & retail | 2025 |
| R T Moffat Ltd | Transport & logistics | 2021 |
| R Tindale (Builder) Limited | Construction | 2000 |
| R.Bucks’ Brakes & Repair Ltd | Wholesale & retail | 2023 |
| Race and Lingard Developments Ltd | Construction | 2025 |
| Raving Pineapple Entertainment Ltd | Arts & recreation | 2024 |
| RAW Horizons Limited | Other services | 2011 |
| RB Utilities (North) Limited | Construction | 2025 |
| Red Supported Living CIC | Hospitality | 2017 |
| REG Motors Limited | Wholesale & retail | 2017 |
| Release Property Investments Ltd | Real estate | 2018 |
| Reoptic Limited | Wholesale & retail | 2016 |
| Resolve Podiatry Ltd | Health & social care | 2022 |
| Revo Coaching Limited | Arts & recreation | 2009 |
| Richmond Roofing & Cladding Limited | Construction | 2006 |
| Ridley Mensforth Media Limited | Professional & scientific | 2015 |
| RIO Suntanning Equipment Ltd | Manufacturing | 2021 |
| RJR Sports & Fitness Centre Ltd | Arts & recreation | 2023 |
| RKG Electrical Services Ltd | Construction | 2014 |
| Road Express Logistics&Consultant Ltd | Transport & logistics | 2022 |
| Rockpool Childrens Books Limited | Information & communication | 2005 |
| Roecad Ltd | Information & communication | 2009 |
| Rope Access Professionals Ltd | Manufacturing | 2026 |
| Rose Trading Company Limited | Wholesale & retail | 1989 |
| Rowlandson Freemasons Hall Company Limited | Hospitality | 1963 |
| Roxy's Barber & Tattoo Studio Ltd | Other services | 2017 |
| ROY Gell Electrical Installations Ltd | Construction | 2019 |
| Ryantrans International Limited | Transport & logistics | 2011 |
| S & S Travel Limited | Transport & logistics | 2000 |
| S B Roofing Solutions Ltd | Construction | 2023 |
| S J Malkin Welding Limited | Manufacturing | 2013 |
| S.R.H. Supplies Ltd | Wholesale & retail | 2014 |
| SAB Contractors Ltd | Construction | 2018 |
| Sacred-Co Ltd | Wholesale & retail | 2025 |
| Safe Transport Logistics Limited | Transport & logistics | 2019 |
| Saints Sled Dog Rescue Ltd | Other services | 2023 |
| SAW Renewables Limited | Financial services | 2022 |
| Sebastian Vehicle Services Ltd | Wholesale & retail | 2025 |
| Secureall Limited | Transport & logistics | 2005 |
| Secureall Self Storage Containers Limited | Transport & logistics | 2014 |
| Secureall Self Storage Limited | Transport & logistics | 2023 |
| Secureall Storage Limited | Transport & logistics | 2023 |
| Security and Monitoring Services Ltd | Administrative & support | 2017 |
| Serendipity Darlington Limited | Hospitality | 2020 |
| Sethow Ltd | Wholesale & retail | 2025 |
| Shay Smith Plumbing & Heating Ltd | Construction | 2022 |
| Sibby Transport Limited | Transport & logistics | 2016 |
| Siciliano Ferryhill Ltd | Hospitality | 2023 |
| Signtime Graphics Limited | Manufacturing | 2004 |
| Silviya Spasova Ltd | Health & social care | 2011 |
| Simply Bespoke Ltd | Manufacturing | 2021 |
| Simply Leisure Group Limited | Transport & logistics | 2023 |
| Sims Traffic Management Limited | Construction | 2017 |
| Smartsociates Ltd | Administrative & support | 2017 |
| Soakworks Ltd | Wholesale & retail | 2024 |
| Solade Ltd | Education | 2019 |
| Spartacus Roofing Ltd | Construction | 2022 |
| Square & Compass PH Limited | Hospitality | 2023 |
| SS Drylining Limited | Construction | 2013 |
| ST Vincent Place Limited | Wholesale & retail | 2018 |
| Starlight Party Events Ltd | Arts & recreation | 2023 |
| Starvall Boarding Ltd | Other services | 2022 |
| Stephen Cram Electrical Services Limited | Construction | 2016 |
| Stihl Paving Ltd | Construction | 2023 |
| Stream for Good Ltd | Information & communication | 2026 |
| Streamline Stars Ltd | Administrative & support | 2025 |
| Summerskye Texels Ltd | Agriculture & fishing | 2025 |
| Super Hand Car Wash Ltd | Administrative & support | 2023 |
| Supportive SRC Ltd | Health & social care | 2000 |
| Sympla Conservatory Roofs Ltd | Manufacturing | 2006 |
| T P Crowley Ltd | Health & social care | 2024 |
| Tait Windows Ltd | Construction | 2023 |
| Taro Trading Ltd | Wholesale & retail | 2024 |
| Teasdale Bulk Haulage Limited | Transport & logistics | 2013 |
| Technichs Design Limited | Professional & scientific | 2013 |
| Teesside's Resources and Assessment Centre of Excellence Ltd | Education | 2025 |
| Tennyson Road Development LLP | | 2012 |
| Terofayhu Ltd | Wholesale & retail | 2026 |
| THE AYE Witness Limited | Wholesale & retail | 2026 |
| THE Cadence Business Solutions Ltd | Professional & scientific | 2025 |
| THE Designated Driver Ltd | Wholesale & retail | 2019 |
| THE Fire Store Limited | Real estate | 2021 |
| THE Go Well Community CIC | Education | 2012 |
| THE Humble Garden CIC | Other services | 2023 |
| THE Rattlin BOG Durham Ltd | Hospitality | 2026 |
| THE Tool Rack Limited | Construction | 2024 |
| THE Voyage Group Ltd | Information & communication | 2024 |
| THE White Horse Ferryhill Limited | Hospitality | 2018 |
| THE Yard of ALE Brewing Company Limited | Manufacturing | 2008 |