| S J Edmonds Ltd | Professional & scientific | 2022 |
| S Jefferson Recruitment Limited | Administrative & support | 2020 |
| S Pittard Consulting Ltd | Information & communication | 2022 |
| S&A Removals Ltd | Transport & logistics | 2025 |
| S&J Partnership Ltd | Real estate | 2013 |
| S&Ots Limited | Professional & scientific | 2018 |
| S&R Property Groups Ltd | Construction | 2026 |
| S&S Windings Holdings Limited | Financial services | 2011 |
| S.M.M. Software Limited | Information & communication | 1991 |
| Sabaya Properties Limited | Real estate | 2021 |
| Sabbab Technologies Ltd | Information & communication | 2021 |
| Sabre Tooth Panda Ltd. | Professional & scientific | 2015 |
| Saint Royale Ltd | Wholesale & retail | 2020 |
| Sajeel Trading Ltd | Wholesale & retail | 2026 |
| Saker Risk Solutions Ltd | Financial services | 2020 |
| Sakura Holdings Limited | Construction | 2017 |
| Salentis (UK) Limited | Professional & scientific | 2018 |
| Sales Channel Ltd | Information & communication | 1998 |
| Sales Cradle Limited | Professional & scientific | 2025 |
| Sales Leadership Ltd | Professional & scientific | 2012 |
| Sally Adams Partnership LLP | | 2007 |
| Saltum Management Limited | Professional & scientific | 2025 |
| Salty Aqua Limited | Extraterritorial | 2017 |
| SAM Dracott Farrier Ltd | Agriculture & fishing | 2022 |
| SAM Gold Nutrition Ltd | Health & social care | 2021 |
| SAM Moulsdale Ltd | Information & communication | 2015 |
| SAM Wilson Holdings Limited | Real estate | 2019 |
| Sam-Cot Limited | Hospitality | 1995 |
| Samantha Child Property Search Ltd | Real estate | 2022 |
| Samar Trading Ltd | Hospitality | 2023 |
| Sambal Ltd | Professional & scientific | 2016 |
| Samuilona Ltd | Professional & scientific | 2020 |
| Sance Consulting Services Limited | Information & communication | 2013 |
| Sanctuary Engineering Limited | Manufacturing | 2016 |
| SANDAW81 Management Consultants Limited | Professional & scientific | 2018 |
| Sandbox Services and Products Limited | Professional & scientific | 2013 |
| Sanders Exhibition Services Limited | Arts & recreation | 2013 |
| Sandrock Building Services Limited | Construction | 1997 |
| Sandrock Developments Limited | Administrative & support | 2010 |
| Sandrock Management Limited | Information & communication | 2005 |
| Sands Park Ltd | Professional & scientific | 2022 |
| Sandy Farm Ltd | Other services | 2020 |
| Sano Swim Ltd | Wholesale & retail | 2025 |
| Sansom Installations Limited | Manufacturing | 2005 |
| Santa Trees Ltd | Wholesale & retail | 2022 |
| Sarah Chard Associates Limited | Administrative & support | 2010 |
| Sarah Reece Jewellery Ltd | Manufacturing | 2023 |
| Saramarx Imagery Limited | Information & communication | 2008 |
| Sarb Consulting Ltd | Real estate | 2010 |
| Sasy Images Limited | Information & communication | 2021 |
| Satchfield Ltd | Other services | 2015 |
| Satias Ltd | Information & communication | 2025 |
| Sauterelle Limited | Administrative & support | 2003 |
| Sawadee Thai Therapy Limited | Other services | 2024 |
| Saxer-Taylor Consulting Ltd | Professional & scientific | 2017 |
| Saxon East Limited | Arts & recreation | 2022 |
| SBH Property Consultancy Ltd | Professional & scientific | 2026 |
| Sbmoore Design Limited | Arts & recreation | 2023 |
| Sbre Ltd | Real estate | 2022 |
| SC Aesthetics & Dermatology Ltd | Health & social care | 2022 |
| Scape Solutions Limited | Other services | 2025 |
| Scct Holdings Ltd | Financial services | 2024 |
| Scct Property Limited | Other services | 2023 |
| Schjodt LLP | | 2019 |
| Schmittat Ltd | Information & communication | 2015 |
| Scholars' Walk (Mayfields) Management Company Limited | Households | 2005 |
| School Lane Management Company Emsworth Limited | Households | 2020 |
| School Leadership Systems Limited | Information & communication | 2008 |
| Scientific IST Ltd | Wholesale & retail | 2021 |
| SCM Resources Limited | Professional & scientific | 2007 |
| Scopus Insights Ltd | Professional & scientific | 2026 |
| Scott Capital Limited | Extraterritorial | 2019 |
| Scott’S Investments Ltd | Real estate | 2025 |
| Scratch 2 Fresh Food Ltd | Hospitality | 2022 |
| Scrimgeour and Company Limited | Real estate | 1981 |
| Scrimgeour Family Investments Ltd | Financial services | 2017 |
| SCS Marketing and PR Limited | Information & communication | 2011 |
| Scutts Farm Ltd | Real estate | 2022 |
| Sea Front Apartments Limited | Real estate | 2018 |
| Seachoice (Scandinavia) Limited | Information & communication | 1987 |
| Seachoice Limited | Information & communication | 1981 |
| Seacocks UK Ltd. | Manufacturing | 2016 |
| Seafood Exchange Limited | Wholesale & retail | 2004 |
| Seafront Fish Bar Ltd | Hospitality | 2015 |
| Seal & SON Ltd | Construction | 2018 |
| Seale Investments Ltd | Real estate | 2023 |
| Seamaster Watersports Ltd | Wholesale & retail | 2023 |
| Sear Site Solutions Ltd | Construction | 2025 |
| Searches Group Limited | Professional & scientific | 2006 |
| Seaseal Ltd. | Manufacturing | 2018 |
| SEB Aird Design Ltd | Professional & scientific | 2024 |
| Seco House (Fleet) Management Company Limited | Households | 2017 |
| Second Barningley Park Residents Association Limited(The) | Households | 1985 |
| Second Grove Farm Residents Association Limited(The) | Households | 1986 |
| Secret Locals Limited | Information & communication | 2025 |
| Sectorsure NO. 10 Limited | Wholesale & retail | 2012 |
| Secure Business Finance Ltd | Financial services | 2021 |
| Secure FIX Roofing Ltd | Construction | 2022 |
| Security World Limited | Administrative & support | 2005 |
| Sefapane Services Ltd | Information & communication | 2023 |