| S & P RAJ Retail Ltd | Wholesale & retail | 2025 |
| S and K Global Investment Limited | Real estate | 2017 |
| S Brothers Limited | Wholesale & retail | 2014 |
| S DOE Carpentry and Construction Ltd | Construction | 2024 |
| S Dunbar Limited | Administrative & support | 2010 |
| S M Decorators Limited | Construction | 2007 |
| S Matthews Motors Limited | Wholesale & retail | 2025 |
| S&N Ventures Ltd | Transport & logistics | 2023 |
| S&P Wellness Limited | Wholesale & retail | 2024 |
| S. K. M. Developments Limited | Construction | 2006 |
| S.Flynn Commercials Ltd | Wholesale & retail | 2025 |
| Sacha Boxall Limited | Manufacturing | 2022 |
| Safezone Asbestos Solutions Ltd | Water & waste | 2023 |
| Saffron Oak Ventures Ltd | Hospitality | 2025 |
| Sagarmatha Services Ltd | Hospitality | 2019 |
| Sagehall Limited | Real estate | 1988 |
| Sahin Kebab Ltd | Hospitality | 2025 |
| Saineet Ltd | Wholesale & retail | 2013 |
| Saint Michael's Abbey Press Limited | Wholesale & retail | 2004 |
| Saiphin Solutions Limited | Information & communication | 2006 |
| Saja Estate Agents Ltd | Construction | 2017 |
| Saja Property Investment Ltd | Construction | 2017 |
| Sajesa Fabrications Limited | Construction | 2018 |
| Salesian College Farnborough Limited | Education | 2008 |
| Salience Nutrition Ltd | Health & social care | 2024 |
| Salon Cabelo Farnham Ltd | Other services | 2021 |
| Salt Building Services Limited | Construction | 2015 |
| Saltdean Lido CIC | Arts & recreation | 2012 |
| Samd Consulting Limited | Professional & scientific | 2018 |
| Sami Barber Limited | Other services | 2024 |
| Samuels Surveyors Ltd | Professional & scientific | 2018 |
| Sandringham Gardens Management Company Limited | Real estate | 2017 |
| Sandy Drive Management Company Limited | Households | 2026 |
| Sangah Logistics Ltd | Transport & logistics | 2016 |
| Sanna Kallinen Ltd | Health & social care | 2014 |
| Sansghar Ltd | Real estate | 2023 |
| Santos Homes Limited | Real estate | 2025 |
| Sanyun Limited | Real estate | 2025 |
| Sarah Lloyd Ltd | Professional & scientific | 2021 |
| Sarah SAN Acupuncture Ltd | Health & social care | 2024 |
| Sarihous Ltd | Real estate | 2025 |
| Saritech Limited | Information & communication | 2018 |
| Sarithou Limited | Real estate | 2025 |
| SAS (Kent) Limited | Transport & logistics | 2015 |
| SAS Evans Ltd | Administrative & support | 2017 |
| Sashya Services Ltd | Information & communication | 2022 |
| Satcom Direct International, Limited | Information & communication | 2011 |
| Satswana Ltd | Information & communication | 2014 |
| Saturday's Child Pictures Ltd | Information & communication | 2026 |
| Satya Parida Vaccine and Diagnostics Consultancy Limited | Professional & scientific | 2021 |
| Saurak Properties Limited | Real estate | 2026 |
| Savvyitsolutions Ltd | Information & communication | 2014 |
| SB Rotorworks Ltd | Manufacturing | 2025 |
| Sbbs Leisure Ltd | Arts & recreation | 2018 |
| SC Transformation Ltd | Professional & scientific | 2021 |
| SCA Safety Compliance Auditing LLP | | 2023 |
| Scaife Construction Ltd | Construction | 2015 |
| Scarlet Dragonfly Ltd | Information & communication | 2017 |
| Scatch Consulting Ltd | Professional & scientific | 2025 |
| School Business Partnership Ltd | Professional & scientific | 2023 |
| Schoolers Ltd | Other services | 2024 |
| Schools OUT for FUN Ltd | Education | 2013 |
| SCJ Holdings Ltd | Financial services | 2024 |
| Scott Wise Ltd | Real estate | 2020 |
| Scott-Russell Sports Cars Ltd | Wholesale & retail | 2017 |
| Scrappydio Gutters Cleaning Ltd | Transport & logistics | 2015 |
| Scrappydio Roofing Limited | Construction | 2018 |
| Scrimp and Spend Ltd | Administrative & support | 2025 |
| Scriven Building Environments Ltd | Information & communication | 2012 |
| Scrutiny UK Limited | Professional & scientific | 2013 |
| SE Consultancy Services Limited | Real estate | 2023 |
| Seacom Services (Accountancy) Ltd | Professional & scientific | 2014 |
| Searchality Ltd | Information & communication | 2017 |
| Season Block Ltd | Wholesale & retail | 2020 |
| Second Law Limited | Professional & scientific | 2014 |
| Secure Surrounds Ltd | Administrative & support | 2019 |
| Secure TEL Limited | Information & communication | 2018 |
| Security and Resilience Consortium Ltd | Other services | 2009 |
| Security Frameworks Ltd | Information & communication | 2024 |
| Security Towers Limited | Manufacturing | 2023 |
| Segen Limited | Other services | 2004 |
| Sekwane Ltd | Transport & logistics | 2021 |
| Select Locals Limited | Extraterritorial | 2007 |
| Senable Family Support Limited | Education | 2026 |
| Sense Business Development Limited | Professional & scientific | 2002 |
| Sentrica Limited | Information & communication | 2002 |
| Sephora Marketing and Design Limited | Professional & scientific | 2022 |
| Serenity Marketing Limited | Professional & scientific | 2022 |
| Serqual Facilities Management Limited | Professional & scientific | 2014 |
| Service Plus Plumbing & Heating Ltd | Construction | 2026 |
| Sesami Cash Management Technologies UK Ltd | Administrative & support | 2021 |
| Sesami Cash Management UK Ltd | Manufacturing | 1984 |
| SET + Scribble Studios Ltd | Professional & scientific | 2025 |
| SET 4 Life Ltd | Education | 2026 |
| SET Education Ltd | Education | 2022 |
| SET4SCHOOL Ltd | Education | 2026 |
| Sethi’S Food & Wine Ltd | Wholesale & retail | 2025 |
| Seventysix Consultancy Limited | Professional & scientific | 2017 |
| Seymour Court Management Company (Fleet) Limited | Households | 1976 |
| Share Necessities Ltd | Financial services | 2021 |