| ROUTES2SUCCESS Limited | Professional & scientific | 2012 |
| Rpas International Ltd | Professional & scientific | 2022 |
| Rs-Geo Limited | Professional & scientific | 2024 |
| RSA Technology Limited | Manufacturing | 1997 |
| RTR Consulting Limited | Construction | 2012 |
| Rural Edge Property Services Ltd | Real estate | 2026 |
| Sabs Online Ltd | Other services | 2018 |
| Salus Global Security Ltd | Professional & scientific | 2024 |
| Sandhills Limited | Other services | 2005 |
| Santino's Italian Limited | Hospitality | 2024 |
| Saunders Farming Limited | Agriculture & fishing | 2016 |
| Sciq Ltd | Administrative & support | 2018 |
| Searis Development Ltd | Construction | 2023 |
| Searis Limited | Construction | 2014 |
| Secure Electrical Limited | Construction | 2017 |
| Secure Safe Storage - Cheltenham Ltd | Transport & logistics | 2026 |
| Secure Safe Storage 2 Ltd | Transport & logistics | 2026 |
| Secure Safe Storage Holdings Ltd | Financial services | 2026 |
| Secure Safe Storage Ltd. | Transport & logistics | 2025 |
| Selby Lowndes Family Solicitors Ltd | Professional & scientific | 2013 |
| Select Commercial Management Limited | Professional & scientific | 2023 |
| Selkirk Harris Flooring Limited | Wholesale & retail | 2015 |
| SEN Holdings Limited | Financial services | 2024 |
| Seven Colville Limited | Households | 1984 |
| SEW Heart Felt Limited | Wholesale & retail | 2013 |
| Shahzad Care Services Ltd | Health & social care | 2019 |
| Shalah Properties Limited | Real estate | 2024 |
| Shamira Hub Ltd | Information & communication | 2026 |
| Shark Blues Ltd | Wholesale & retail | 2024 |
| Sharpened Mango Systems Limited | Information & communication | 2012 |
| Shop Fair Price Ltd | Wholesale & retail | 2024 |
| Shrivenham Park LLP | | 2014 |
| Silverback Fire Solutions Ltd | Financial services | 2023 |
| Sixpenny Limited | Education | 2002 |
| Skaz Limited | Professional & scientific | 2016 |
| SKO Link Limited | Transport & logistics | 2013 |
| Small Friends Limited | Education | 2001 |
| Smart Move Travels Limited | Wholesale & retail | 2020 |
| Smartklub Limited | Information & communication | 2014 |
| Solar Clean Electric Ltd | Energy | 2011 |
| Solas Oxford Community Interest Company | Health & social care | 2021 |
| Sower Hill Stables Limited | Agriculture & fishing | 2014 |
| Spenle Wellman Ltd | Administrative & support | 2024 |
| Spinage Management Limited | Households | 2018 |
| Spiny Software Ltd | Information & communication | 2008 |
| Sport Psychotherapy Services Ltd | Education | 2017 |
| Squigglespace Ltd | Administrative & support | 2026 |
| SRH Bricklaying Ltd | Construction | 2019 |
| SS Backing and Breaking Limited | Other services | 2025 |
| SS Equestrian Marketing Ltd | Information & communication | 2025 |
| SS Equestrian Rehab Services Ltd | Arts & recreation | 2025 |
| SS Rescue Bloodstock Ltd | Other services | 2025 |
| SS Stable Livery Limited | Agriculture & fishing | 2025 |
| ST Christopher's Consulting Ltd | Professional & scientific | 2024 |
| ST. Nicholas Nursery Limited | Education | 1994 |
| Stanford Business Court Limited | Real estate | 1997 |
| Stanford Coffee Shop Ltd | Hospitality | 2020 |
| Stanford in the Vale Pre-School | Education | 2010 |
| Stanford Publishing Limited | Information & communication | 2006 |
| Starfield Equestrian Ltd | Wholesale & retail | 2025 |
| Stewart Brothers Property Clanfield Ltd | Construction | 2021 |
| Stewart Brothers Property Ltd | Construction | 2014 |
| Stewart Land Ltd | Construction | 2012 |
| Stibbards' Property Limited | Other services | 2016 |
| Still and Motion Media Ltd | Information & communication | 2026 |
| Stirling Hinkley Usability Limited | Professional & scientific | 2007 |
| STL Exterior Cleaning Ltd | Professional & scientific | 2023 |
| Storage for ALL Ltd | Other services | 2007 |
| Student United Limited | Information & communication | 2014 |
| Sudbury House Limited | Hospitality | 2013 |
| Summerside Management Ltd | Information & communication | 2023 |
| Sunhill Daycare (Europe) Limited | Education | 1997 |
| Svitlana Nails Shop Ltd | Wholesale & retail | 2026 |
| SWAN1513 LLP | | 2026 |
| Swfabrications Ltd | Manufacturing | 2026 |
| T.M. Sparke Ltd | Information & communication | 2002 |
| Tarnung Ltd | Wholesale & retail | 2014 |
| Technical Engineering Projects Limited | Manufacturing | 2022 |
| Tempelex Ltd | Transport & logistics | 2021 |
| Tessaline & Co Care Ltd | Public administration | 2025 |
| TG Tree Services Ltd | Agriculture & fishing | 2024 |
| THE Branded Candle Co Limited | Manufacturing | 2021 |
| THE Catalyst Company Group Ltd | Information & communication | 2025 |
| THE Elms Management Company (Faringdon) Limited | Households | 1991 |
| THE Gelly Tips Ltd | Other services | 2025 |
| THE Knitting Company Ltd | Professional & scientific | 2012 |
| THE Lavender Bathroom Company Limited | Construction | 2014 |
| THE Learning Habit Limited | Professional & scientific | 1994 |
| THE Little Goat Soap Company Limited | Manufacturing | 2013 |
| THE Little Knitting Co Ltd | Wholesale & retail | 2021 |
| THE Martens Residents Management Company Limited | Households | 2016 |
| THE Milestone Detox Limited | Health & social care | 2014 |
| THE Old Estate Yard Management Company Limited | Professional & scientific | 1998 |
| THE Old Overcliff Hotel Limited | Hospitality | 2026 |
| THE Old Station Nursery Limited | Education | 2002 |
| THE Oxford Business Consultancy Limited | Real estate | 1994 |
| THE Patio & Landscaping Group Ltd | Administrative & support | 2026 |
| THE Purple Plumbing People Limited | Construction | 2012 |
| THE Roofing Company Group Ltd | Construction | 2025 |
| THE Safety Academy Ltd | Professional & scientific | 2024 |