| SGS Equipment Services Limited | Administrative & support | 2003 |
| SGS Surveys Ltd | Construction | 2018 |
| Shadow Digital Media Limited | Administrative & support | 2008 |
| Shadow Learning Ltd | Education | 2024 |
| Shakespeare Mews Residents Association (1999) Limited | Households | 1999 |
| Shamblehurst Lane Management Co Ltd | Households | 2018 |
| Shandwick Place Specsavers Hearcare Limited | Wholesale & retail | 2025 |
| Shandwick Place Specsavers Limited | Wholesale & retail | 2003 |
| Shandwick Place Visionplus Limited | Wholesale & retail | 2003 |
| Sharon Odain Ltd | Health & social care | 2026 |
| Sharp Limited | Wholesale & retail | 2004 |
| Sharpe Engineering Solutions Limited | Professional & scientific | 2004 |
| Sharpy Edge Limited | Wholesale & retail | 2016 |
| Shaw Stone (Commercial) Limited | Manufacturing | 2004 |
| Shawnee TS Jerk PAN Limited | Hospitality | 2025 |
| Shedfield Construction Limited | Construction | 2014 |
| Shedfield Limited | Agriculture & fishing | 2010 |
| Sheedah Beauty Limited | Other services | 2024 |
| Sheep Chakra Properties Limited | Real estate | 2026 |
| Sheer Research & Advisory Ltd | Professional & scientific | 2021 |
| Sheerness Specsavers Limited | Wholesale & retail | 2018 |
| Sheffield 2 Domiciliary Specsavers Limited | Wholesale & retail | 2014 |
| Sheffield Specsavers Hearcare Limited | Wholesale & retail | 2007 |
| Sheffield Specsavers Limited | Wholesale & retail | 1986 |
| Sheffield Visionplus Limited | Wholesale & retail | 1994 |
| Shekhar Associates Limited | Professional & scientific | 2012 |
| Shellau Contracts Limited | Professional & scientific | 2002 |
| Shells Toys and Gifts Limited | Wholesale & retail | 2012 |
| Shenleybury House Limited | Health & social care | 1990 |
| Shepherds Bush Specsavers Limited | Wholesale & retail | 2004 |
| Shepherds Bush Visionplus Limited | Wholesale & retail | 2004 |
| Sheridan Foot Health (Portchester) Ltd | Health & social care | 2013 |
| Sheringham Specsavers Limited | Wholesale & retail | 2017 |
| Shifnal Specsavers Limited | Wholesale & retail | 2024 |
| Shikumen Ltd | Hospitality | 2025 |
| Shilling & Shilling Ltd | Professional & scientific | 2022 |
| Shindins Ltd | Hospitality | 2022 |
| Shipley Specsavers Limited | Wholesale & retail | 2005 |
| Shipley Visionplus Limited | Wholesale & retail | 2005 |
| Shirley Specsavers Limited | Wholesale & retail | 2003 |
| Shms Accountants (Bournemouth) Ltd | Professional & scientific | 2025 |
| Shms Accountants Ltd | Professional & scientific | 1998 |
| Shms Contracting (Southern) Ltd | Construction | 2013 |
| Shms Contracting (UK) Ltd | Professional & scientific | 2013 |
| Shms Contracting Limited | Construction | 2009 |
| Shoo 592 Limited | Real estate | 2013 |
| Shoot ME Productions Limited | Information & communication | 2013 |
| Shop Force Ltd | Wholesale & retail | 2021 |
| Shop Stanhope Ltd | Wholesale & retail | 2026 |
| Shore Residential Surveyors Ltd | Professional & scientific | 2014 |
| Shoreland Holdings Limited | Financial services | 1999 |
| Shoretees Ltd | Wholesale & retail | 2020 |
| Shortland Psychology Associates Limited | Health & social care | 2012 |
| Shotton Specsavers Limited | Wholesale & retail | 2026 |
| Showcase Training Ltd | Education | 2014 |
| Showcase UK (South) Limited | Information & communication | 2020 |
| SHP Chester Limited | Real estate | 2020 |
| SHP Investments 1 Limited | Real estate | 2020 |
| SHP Investments 2 Limited | Real estate | 2020 |
| SHP Investments 3 Limited | Real estate | 2020 |
| SHP Investments 4 Limited | Real estate | 2021 |
| SHP Investments 5 Limited | Real estate | 2022 |
| SHP Investments CC Ltd | Health & social care | 2013 |
| Shrewsbury Specsavers Hearcare Limited | Wholesale & retail | 2003 |
| Shropshire Newmedica Limited | Health & social care | 2019 |
| Shuffleton Properties Limited | Real estate | 2021 |
| Shxl Ltd | Professional & scientific | 2018 |
| Shxo Limited | Information & communication | 2026 |
| Shyam Art Ltd | Arts & recreation | 2024 |
| Si&C Ltd | Professional & scientific | 2023 |
| Siam Group Ltd | Financial services | 2026 |
| Sibb Projects Limited | Professional & scientific | 2024 |
| Sidcup Specsavers Limited | Wholesale & retail | 2002 |
| Sidekick Consultants Limited | Real estate | 2018 |
| Sids NE Ltd | Construction | 2026 |
| Sidus Group Limited | Financial services | 2026 |
| Sienna Earth Limited | Administrative & support | 2001 |
| Sienna Hosta Limited | Agriculture & fishing | 2016 |
| Sienna's Baby Boutique Limited | Wholesale & retail | 2017 |
| Sierra Gynaecology Limited | Health & social care | 2013 |
| SIG Holdings Limited | Financial services | 2015 |
| Sigma Freight Systems Limited | Information & communication | 2004 |
| Signature Catering Group Limited | Hospitality | 2002 |
| Signature Design Architecture Ltd | Professional & scientific | 2023 |
| Signature Drive Chauffeurs Ltd | Transport & logistics | 2022 |
| Signifai Limited | Information & communication | 2026 |
| Signshack Limited | Professional & scientific | 2025 |
| Silent Buddy Co Ltd | Wholesale & retail | 2025 |
| Sillion Ltd | Professional & scientific | 2018 |
| Silvanus Properties Ltd | Real estate | 2015 |
| Silver Birch Branch Limited | Professional & scientific | 2025 |
| Silver Spider Tours Ltd | Arts & recreation | 2024 |
| Silverbox Production Ltd | Arts & recreation | 2015 |
| Simmons Electrical Ltd | Professional & scientific | 2018 |
| Simmons Engineering (Southampton) Limited | Extraterritorial | 1967 |
| Simon Barrable Consulting Ltd | Professional & scientific | 2022 |
| Simon Installation Services Limited | Construction | 2004 |
| Simon Maughan and Associates Limited | Real estate | 2009 |
| Simplify and Transform Limited | Professional & scientific | 2017 |
| Simply Cabinets Ltd | Manufacturing | 2019 |