| Remnant Christian Network Devon Ltd | Other services | 2026 |
| Remote Observatory Limited | Professional & scientific | 2024 |
| Remote Trauma Limited | Health & social care | 2000 |
| Removo Ltd | Transport & logistics | 2025 |
| Remy Lengths Limited | Other services | 2020 |
| Render Creative Ltd | Information & communication | 2018 |
| Rendercore Limited | Construction | 2020 |
| Rendered Pictures Limited | Information & communication | 2016 |
| Rendezvous 10 Ltd | Hospitality | 2006 |
| Renew Consultancy UK Ltd | Professional & scientific | 2021 |
| Renew Women's Fitness & Wellbeing Ltd | Arts & recreation | 2025 |
| Renniks Property Limited | Real estate | 2019 |
| Renovate (SW) Ltd | Construction | 2024 |
| Renovated With Love Limited | Households | 2025 |
| Rent My Property (South West) Ltd | Real estate | 2022 |
| Rental Republic Limited | Administrative & support | 2011 |
| Rentunique Limited | Real estate | 2015 |
| Repair Wizard (SW) Limited | Manufacturing | 2020 |
| Residential Acquisitions Ltd | Real estate | 2022 |
| Resin Solutions Limited | Construction | 2022 |
| Resinissima Ltd | Wholesale & retail | 2026 |
| Resolute 360 Waste Ltd | Water & waste | 2020 |
| Resolution Estates Limited | Construction | 2021 |
| Restart Consulting Limited | Information & communication | 2003 |
| Restaurant Inc. Ltd | Hospitality | 2018 |
| Resurgam (West END) Limited | Real estate | 2013 |
| Resurgam Limited | Extraterritorial | 2023 |
| Rethink Business Group Ltd | Financial services | 2019 |
| Rethink Business Ltd | Professional & scientific | 2009 |
| Retreat Boatyard (Topsham) Limited | Manufacturing | 1970 |
| Retreat Management Company Limited(The) | Households | 1959 |
| Retro Kings Coffee Limited | Hospitality | 2020 |
| Revardis Limited | Professional & scientific | 2022 |
| Revell Research Systems Limited | Information & communication | 2009 |
| Revill Design Group Limited | Financial services | 2024 |
| Revill Design Ltd | Manufacturing | 2014 |
| Revill Industrial Finishes Limited | Extraterritorial | 1965 |
| Revise Right Ltd | Education | 2018 |
| Revival Speedworks Limited | Manufacturing | 2025 |
| Revive H2 UK Ltd | Professional & scientific | 2025 |
| Revolution Aesthetics Exeter @ the HUT Ltd | Other services | 2023 |
| Revolution Consulting Limited | Health & social care | 2006 |
| Revscale Limited | Administrative & support | 2021 |
| Rewe Barton Management Company Limited | Administrative & support | 2000 |
| Rewe Court Management Limited | Households | 1998 |
| Rewild Swimwear Limited | Wholesale & retail | 2023 |
| Reword Limited | Information & communication | 2023 |
| REX Property Limited | Real estate | 2019 |
| REX Ridge Property Limited | Real estate | 2021 |
| REY Bridge House Limited | Financial services | 2023 |
| Reynard Consulting (NW) Ltd | Wholesale & retail | 2026 |
| Rezcomm Group Limited | Financial services | 2025 |
| Rezcomm Limited | Extraterritorial | 2014 |
| RFL Company Services Ltd | Professional & scientific | 2016 |
| Rflcs Ltd | Professional & scientific | 2019 |
| RFP Rentals Ltd | Real estate | 2025 |
| RGG Plumbing & Heating Ltd | Construction | 2023 |
| RH Advertising Limited | Professional & scientific | 2000 |
| RH Advertising Trustees Limited | Professional & scientific | 2025 |
| RH Edmonds Limited | Wholesale & retail | 2012 |
| RH Product Design Limited | Professional & scientific | 2020 |
| RH Trading Southwest Ltd | Wholesale & retail | 2016 |
| Rheal Estates Ltd | Real estate | 2026 |
| RHG Trading Ltd | Wholesale & retail | 2011 |
| Rhino Auto Electrics Limited | Wholesale & retail | 2003 |
| Rhok Holdings Ltd | Arts & recreation | 2015 |
| Rhombus Asset Holdings Ltd | Real estate | 2014 |
| RHR Property (Devon) Limited | Construction | 2018 |
| Rice Contractors Ltd | Construction | 2023 |
| Richard Chappell Dance CIC | Arts & recreation | 2020 |
| Richard Green Ecology Limited | Professional & scientific | 2010 |
| Richard Hocking Associates Limited | Professional & scientific | 1992 |
| Richard Morley Surveys Ltd. | Professional & scientific | 2017 |
| Richard Simic Design Limited | Professional & scientific | 2014 |
| Richards Builders Limited | Construction | 2018 |
| Richards Fire & Security Ltd | Construction | 2026 |
| Richards Holiday Holdings Limited | Hospitality | 2023 |
| Richardson Engineering Services Ltd | Wholesale & retail | 2013 |
| Richie Brooks Limited | Construction | 2014 |
| Richil Limited | Professional & scientific | 2020 |
| Richmond MOT Centre Ltd | Wholesale & retail | 2014 |
| Rick Stokes Transport Ltd | Transport & logistics | 2021 |
| Ridgespear Limited | Construction | 2017 |
| Ridgeway Information Ltd | Professional & scientific | 2012 |
| Rifles 2 Rakes Ltd | Administrative & support | 2019 |
| Right Angle Finishing Ltd | Manufacturing | 2016 |
| Right Angle Finishing Trustees Limited | Administrative & support | 2022 |
| Right at Home Estate Agents Limited | Real estate | 2024 |
| Right Surveyors South West Ltd | Other services | 2011 |
| Rights Reimagined Ltd | Information & communication | 2012 |
| RIJ Consult Ltd | Administrative & support | 2024 |
| Riley Aviation Limited | Transport & logistics | 2025 |
| Riley Inc Limited | Real estate | 2024 |
| Rincon Projects Ltd | Construction | 2011 |
| Ringsted Invest Limited | Real estate | 1989 |
| Rinkle Limited | Professional & scientific | 1985 |
| Ripley Wales Financial Planning Ltd | Financial services | 2002 |
| Rise & Shine (South West) Ltd | Administrative & support | 2025 |
| Rise and Rewild CIC | Health & social care | 2022 |
| Risheng Gourmet Limited | Hospitality | 2025 |