| QED Applications Ltd | Information & communication | 2018 |
| QED Projects Limited | Professional & scientific | 2015 |
| QED Property Limited | Real estate | 2023 |
| QTS National Ltd | Construction | 2022 |
| Quadpharma Limited | Wholesale & retail | 2022 |
| Quality Interior Solutions Ltd | Construction | 2020 |
| Quality Print Limited | Administrative & support | 2016 |
| Quality Standard Consultancy Ltd | Administrative & support | 2019 |
| Quanta Renewables Ltd | Construction | 2023 |
| Quantarla Consulting Limited | Construction | 2021 |
| Quanterra Systems Ltd | Professional & scientific | 2021 |
| Quantock Electric Company Limited | Wholesale & retail | 1938 |
| Quantum Property Search Limited | Real estate | 2024 |
| Quarter's Force Limited | Transport & logistics | 2022 |
| Quarterdeck Hotels LLP | | 2024 |
| Quarterdeck Investments Ltd | Real estate | 2018 |
| Quay Accounts (Devon) Limited | Professional & scientific | 2002 |
| Quay and Co Property Limited | Real estate | 2023 |
| Quay and Co Property Partnership LLP | | 2023 |
| Quay Construction and Glazing Limited | Construction | 2022 |
| Quay Fitness Academy Ltd | Education | 2025 |
| Quay IT Computers LLP | | 2010 |
| Quay Law (Holdings) Limited | Financial services | 2012 |
| Quayside Cafe Exeter Ltd | Hospitality | 2023 |
| Quayside Distilling Limited | Manufacturing | 2021 |
| Quayside MOT and Tyre Limited | Wholesale & retail | 2019 |
| Quayside Technical Services Limited | Information & communication | 2001 |
| Queen Street Carpets (1973) Limited | Wholesale & retail | 1973 |
| Queen's Drive Exmouth Community Interest Company | Real estate | 2017 |
| Queens Head Hotel (Exeter) Ltd | Professional & scientific | 2013 |
| Queensmead Farm Limited | Agriculture & fishing | 2025 |
| Queensmead Ltd | Agriculture & fishing | 2019 |
| Quelab Limited | Wholesale & retail | 2025 |
| Quick Attach Ltd | Professional & scientific | 2015 |
| Quick FIX Plumbing Southwest Ltd | Construction | 2026 |
| Quick Look Media Limited | Information & communication | 2016 |
| Quick Move Ltd | Wholesale & retail | 2015 |
| Quick Stop Market (Exeter) Ltd | Wholesale & retail | 2019 |
| Quick-Tracks Limited | Administrative & support | 2009 |
| Quickes Traditional Limited | Agriculture & fishing | 2002 |
| Quickprint (Southwest) Limited | Manufacturing | 2002 |
| Quinn Logistics Consultancy Limited | Transport & logistics | 2020 |
| Quintessa Group Ltd | Wholesale & retail | 2025 |
| Quirk Theatre CIC | Arts & recreation | 2017 |
| Quirky Advocates CIC | Health & social care | 2025 |
| Quirky Jobs Ltd | Professional & scientific | 2023 |
| Quite Brazen Entertainment Limited | Arts & recreation | 2014 |
| Quote Monkey Ltd | Financial services | 2012 |
| QW Catering Limited | Manufacturing | 2018 |
| QW Consultancy Limited | Professional & scientific | 2018 |
| QW Events Limited | Hospitality | 2018 |
| QW International Limited | Financial services | 2018 |
| R & C Broomby Limited | Health & social care | 2015 |
| R & H Roofing Services Limited | Construction | 2013 |
| R & J Business Solutions Limited | Professional & scientific | 2011 |
| R & M Duchy Limited | Hospitality | 2021 |
| R & R Interiors (SW) Ltd | Construction | 2017 |
| R & S Catering (Chudleigh) Limited | Hospitality | 2007 |
| R & S Meyer Ltd | Health & social care | 2015 |
| R & S Services (Devon) Limited | Construction | 2003 |
| R a H Electrical Services Limited | Construction | 2016 |
| R B PVC Ltd | Construction | 2016 |
| R C Goodier Ltd | Construction | 2003 |
| R C S Couriers Ltd | Wholesale & retail | 2010 |
| R Ford Aviation Consultants Ltd | Professional & scientific | 2022 |
| R J C Estates Limited | Real estate | 2010 |
| R J Tyres (Southwest) Limited | Wholesale & retail | 2011 |
| R Kempthorne & Partners Limited | Agriculture & fishing | 2021 |
| R Kitchen Fitters Ltd | Construction | 2018 |
| R Renovation Limited | Professional & scientific | 2024 |
| R S Roofing Solutions Limited | Construction | 2014 |
| R S T Leisure Ltd | Hospitality | 1986 |
| R Squared Delivering Solutions Ltd | Transport & logistics | 2025 |
| R W & J Skinner Ltd | Professional & scientific | 2011 |
| R W Jago Plastering Limited | Construction | 2019 |
| R&B Services (SW) Ltd | Construction | 2024 |
| R&Dm Holdings Ltd | Financial services | 2024 |
| R&J Commercial Services Limited | Wholesale & retail | 2022 |
| R&K Outdoor Leadership Ltd | Arts & recreation | 2023 |
| R&L Event Partners Ltd | Wholesale & retail | 2026 |
| R&N Transfers (Southwest) Ltd | Transport & logistics | 2025 |
| R&R Wall Limited | Real estate | 2019 |
| R. & J. Maritime Limited | Other services | 1986 |
| R. a. Downing Contractors Limited | Construction | 2003 |
| R. DEW Ltd | Construction | 2025 |
| R. Owen Landscaping & Building Ltd | Administrative & support | 2024 |
| R.A.W. Energy (SW) Limited | Construction | 2013 |
| R.J.C.L Limited | Construction | 2020 |
| R.S Bristol Building Ltd | Wholesale & retail | 2019 |
| R.S. Groundworks Limited | Construction | 2003 |
| R.S.O.R Limited | Construction | 2020 |
| R1 Repairs & Installations Ltd | Construction | 2025 |
| R2L Consulting Ltd | Information & communication | 2026 |
| RA Inc Limited | Wholesale & retail | 2015 |
| RAB Computer Services Limited | Information & communication | 1991 |
| Raceworld Limited | Arts & recreation | 1994 |
| Rachael Currie Limited | Health & social care | 2018 |
| Racjac Solutions Ltd. | Information & communication | 2017 |
| RAD Waves Limited | Health & social care | 2023 |
| Radd Consultancy Ltd | Professional & scientific | 2026 |