| Sharifs Alterations and Embroidery Services Ltd | Wholesale & retail | 2023 |
| Shark Developments Ltd | Financial services | 2023 |
| Sharkham Village Management NO 1 Limited | Real estate | 2005 |
| Sharp Cat Ltd | Administrative & support | 2003 |
| Sharp Cleaning Limited | Administrative & support | 2021 |
| Sharp Ears Properties Limited | Real estate | 2022 |
| Sharper Roofing Limited | Extraterritorial | 2021 |
| Shauls Properties Limited | Real estate | 2017 |
| Shaw Welding (Launceston) Ltd | Wholesale & retail | 2014 |
| Sheep Improved Genetics Limited | Agriculture & fishing | 2008 |
| Shel Properties Limited | Real estate | 2019 |
| Sheldon Lane Ltd | Other services | 2024 |
| Sheldon Limited | Other services | 2002 |
| Shepherds Court Estate Management Company Ltd | Real estate | 2017 |
| Sheppard Rockey & Williams Limited | Professional & scientific | 2005 |
| Sherwood Business Design Ltd | Professional & scientific | 2020 |
| Sherwood Hotel (Nottingham) Ltd | Hospitality | 2016 |
| Shibori Limited | Manufacturing | 2020 |
| Shield and Seeds Homes Limited | Real estate | 2025 |
| Shield Retail Centre (Man.Co.) Limited | Real estate | 1998 |
| Shillingford Organics Farm School CIC | Education | 2018 |
| Shine Angel's Ltd | Administrative & support | 2024 |
| Shine K9 Doggy Day Care Ltd | Other services | 2026 |
| Shiny Star Car Wash Limited | Administrative & support | 2020 |
| Shiny Stars Hand Car Wash Ltd | Administrative & support | 2025 |
| Shipman Financial Planning Limited | Financial services | 2009 |
| Shipman Group Holdings Limited | Financial services | 2018 |
| Shipman Group Limited | Professional & scientific | 2000 |
| Shipman Holdings Limited | Financial services | 2018 |
| Shipman Wealth Management Ltd | Financial services | 1993 |
| Shippen Barton Management Company Limited | Households | 2005 |
| Shirehampton House Management Company Limited | Households | 2010 |
| Shlsp Medical Limited | Health & social care | 2017 |
| Shoal Projects Limited | Professional & scientific | 2002 |
| Shoall Holdings Ltd | Real estate | 2025 |
| Shoals Restaurant Ltd | Hospitality | 2022 |
| Shoebrand Limited | Wholesale & retail | 2025 |
| Shop Aura Ltd | Wholesale & retail | 2025 |
| Shop&More Limited | Wholesale & retail | 2023 |
| Shopsage Ltd | Information & communication | 2025 |
| Shoreline Developments Limited | Construction | 2006 |
| Short Accounts Limited | Professional & scientific | 2022 |
| Short Run Press Limited | Manufacturing | 1980 |
| Short Stays UK South West Ltd | Real estate | 2022 |
| Short Ventures Property Limited | Information & communication | 2015 |
| Showbitz Ltd | Arts & recreation | 2010 |
| Shps Services Limited | Professional & scientific | 2022 |
| Shrellex Consulting Ltd | Professional & scientific | 2024 |
| Shropham Conservation Limited | Real estate | 2023 |
| Shsp Property Limited | Real estate | 2018 |
| Shutterrific Limited | Construction | 2024 |
| Shuvra Ltd | Transport & logistics | 2026 |
| SHW Project Management Ltd | Professional & scientific | 2025 |
| Shwap Technologies Ltd | Information & communication | 2021 |
| Shwpco Ltd | Hospitality | 2025 |
| Siberia (B.C.) Limited | Wholesale & retail | 1992 |
| Siblyback Conservation Limited | Real estate | 2023 |
| Sidaways Limited | Professional & scientific | 2001 |
| Sideminds Limited | Professional & scientific | 2022 |
| Sidholme Holiday and Rentals Limited | Real estate | 2026 |
| Sidholme Living Limited | Construction | 2026 |
| Sidmouth Road Car Park Ltd | Professional & scientific | 2021 |
| Sidney Pratt (Builders) Limited | Construction | 1937 |
| Sidney Properties Limited | Real estate | 1945 |
| Sidwell Fish & Chips Limited | Hospitality | 2023 |
| Sidwell Street Chipy Ltd | Hospitality | 2025 |
| Sierra Homes Ltd | Real estate | 2020 |
| Sigma Technical Limited | Professional & scientific | 2016 |
| Signature Barbers (Exeter) Limited | Other services | 2026 |
| Signature Barbers (Plymouth) Limited | Other services | 2026 |
| Signet Publishing Ltd | Information & communication | 2016 |
| Significant BIT Ltd | Education | 2008 |
| Signum Design Ltd | Professional & scientific | 2002 |
| Sika Healthcare Limited Limited | Health & social care | 2023 |
| Silai Care Limited | Extraterritorial | 2013 |
| Silent Social Limited | Arts & recreation | 2011 |
| Silenzio Bruno Limited | Agriculture & fishing | 2025 |
| Silk Group Limited | Wholesale & retail | 1999 |
| Siltpig Ltd | Wholesale & retail | 2025 |
| Silvatech Solutions Ltd | Information & communication | 2022 |
| Silver Fern Developments Limited | Construction | 2019 |
| Silver Financial LLP | | 2023 |
| Silver FOX IT Ltd | Information & communication | 2022 |
| Silver Frog Developments Ltd | Construction | 2025 |
| Silver Frog Properties Limited | Construction | 2019 |
| Silver Street Farm Properties Limited | Real estate | 2023 |
| Silvere Ltd | Real estate | 1998 |
| Silvermaple Property Ltd | Real estate | 2016 |
| Silverpiper Engineering Ltd | Professional & scientific | 2020 |
| Silverspear Property Ltd | Real estate | 2016 |
| Silversprings Hotel Limited | Hospitality | 2002 |
| Silverstar Living Solutions Ltd | Real estate | 2026 |
| Silverton Hunt Limited | Agriculture & fishing | 2006 |
| Silverton Wines Ltd | Manufacturing | 2017 |
| Silverton.Org (Devon) CIC | Other services | 2013 |
| Silvus Limited | Manufacturing | 2014 |
| Sime Living Ltd | Real estate | 2026 |
| Simon Bastone Associates Ltd | Professional & scientific | 2002 |
| Simon Charles Designs Ltd | Professional & scientific | 2023 |
| Simon Geary Ecology Services Limited | Professional & scientific | 2013 |