| S & D Plastering (Services) Ltd | Construction | 2011 |
| S & E Scaffold Services Ltd | Construction | 2023 |
| S & S Auto Motor Service Limited | Wholesale & retail | 2020 |
| S Clark Transport Limited | Transport & logistics | 2025 |
| S J D Agritech Limited | Professional & scientific | 2025 |
| S J Hayler Ltd | Real estate | 2026 |
| S J Roberts & Co (Tax Services) Ltd | Professional & scientific | 2013 |
| S M L Couriers Limited | Transport & logistics | 2012 |
| S T Holland Fire Protection UK Limited | Construction | 2008 |
| S&J Roofing Solutions Ltd | Construction | 2026 |
| S&L Solutions Ltd | Professional & scientific | 2024 |
| S&M Consulting Ltd | Administrative & support | 2016 |
| S&Nw Services Limited | Financial services | 2015 |
| S&P Express Logistics Ltd | Transport & logistics | 2020 |
| S.E.R.K. Construction Limited | Construction | 1996 |
| S.G Property (2025) Limited | Real estate | 2025 |
| S.G Valves & Engineering Services Limited | Manufacturing | 2004 |
| S.M. Murphy Associates Limited | Hospitality | 1991 |
| S8 Recruit Ltd | Administrative & support | 2019 |
| SA Kitchen Restaurant Ltd | Hospitality | 2025 |
| Saberton Farm Limited | Real estate | 2018 |
| Sacha Interiors Limited | Construction | 2012 |
| Safe Access Systems Ltd | Construction | 2016 |
| Safety in Action Ltd | Professional & scientific | 2014 |
| Saint Tropez Tanning Ltd | Professional & scientific | 2017 |
| SAL Electrical Limited | Construction | 2012 |
| Sales Nova Limited | Professional & scientific | 2010 |
| Salon Strand Limited | Other services | 2013 |
| Salt and Pepper POT Ltd | Hospitality | 2021 |
| Salva Veritate Limited | Professional & scientific | 2006 |
| Samba Brazilian Futebal Academy Limited | Arts & recreation | 2025 |
| Samm Software Services Ltd | Information & communication | 2020 |
| Sams Cotswold Kitchen Ltd | Hospitality | 2020 |
| Sanco Badsey Limited | Wholesale & retail | 2004 |
| Sanco Capital Ltd | Financial services | 2015 |
| Sanco Properties Ltd | Real estate | 2015 |
| Sandalwood Construction Limited | Administrative & support | 2013 |
| Sankhara Wellbeing Ltd | Health & social care | 2024 |
| Santony Trans Ltd | Transport & logistics | 2022 |
| Santosario Limited | Real estate | 2022 |
| Sany Seam & Stitch Ltd | Manufacturing | 2025 |
| Sapor Table Ltd | Hospitality | 2025 |
| Sapphire Lakes Limited | Professional & scientific | 2015 |
| Sapphire Property MK Limited | Real estate | 2016 |
| Sarah J Snape Ltd | Other services | 2023 |
| Sassanid Scientific Services & Consulting Ltd | Extraterritorial | 2024 |
| Saunders Roberts LLP | | 2009 |
| Saunders Roberts Solicitors Limited | Professional & scientific | 1991 |
| Sausage and Wine Limited | Wholesale & retail | 2017 |
| Sausage Dog Entertainment Ltd | Information & communication | 2012 |
| Savage Sports Therapy Limited | Health & social care | 2015 |
| Saving Lives With Bleed Kits CIC | Health & social care | 2024 |
| SBK (N&B) Limited | Real estate | 2021 |
| SBK Commercial Ltd | Real estate | 2025 |
| SBK Professional Services Ltd | Real estate | 2021 |
| SBK Sales Limited | Real estate | 2016 |
| SBS Transport Ltd | Transport & logistics | 2019 |
| SC Construction & Build Limited | Construction | 2009 |
| Scalpmicrotech Limited | Other services | 2019 |
| SCC Development & Construction Limited | Construction | 2024 |
| Scents on the Green Limited | Wholesale & retail | 2020 |
| Scotts Plant and Haulage Limited | Transport & logistics | 2016 |
| Scout Apps Limited | Information & communication | 2017 |
| Scrimshire Limited | Administrative & support | 2015 |
| Scuderia Potenza Ltd | Wholesale & retail | 2020 |
| SDA Property Group Ltd | Real estate | 2025 |
| Sebinar Ltd | Administrative & support | 2022 |
| Sebzac BKS Ltd | Real estate | 2023 |
| Sebzac Ltd | Real estate | 2020 |
| Second Eleven Ltd. | Information & communication | 2016 |
| Secret Spice Ltd. | Professional & scientific | 1996 |
| Securehold Holdings Limited | Financial services | 2019 |
| Securehold Investments Limited | Real estate | 1989 |
| Securelec Southwest Ltd | Construction | 2018 |
| Seed Marketing Communications Limited | Professional & scientific | 2005 |
| Seelie Legal Services Limited | Administrative & support | 2024 |
| Select Design (Wolverhampton) Ltd | Manufacturing | 2016 |
| Selective Leasing Limited | Water & waste | 2008 |
| Separite Limited | Wholesale & retail | 2004 |
| Serdee Ltd | Hospitality | 2026 |
| Serrano Web Ltd | Information & communication | 2023 |
| Service for ALL Limited | Agriculture & fishing | 2017 |
| Severn Estuary Limited | Hospitality | 2005 |
| Severnside Developments Ltd | Construction | 2011 |
| SFI (Midland) Limited | Manufacturing | 2005 |
| SGB Architectural Design Ltd | Professional & scientific | 2015 |
| SH Property Sourcing Ltd | Real estate | 2026 |
| Shacks Shacks Ltd | Real estate | 2018 |
| Shahfletcher Limited | Financial services | 2021 |
| Sharp Developments (Evesham) Limited | Extraterritorial | 2012 |
| Sharp Properties Cornwall Limited | Real estate | 2019 |
| Sharp Properties Four Pools Limited | Real estate | 2016 |
| Sharp Properties Holdings Limited | Financial services | 2016 |
| Sharp Properties Tewkesbury Limited | Real estate | 2016 |
| Sharp Properties Vale Limited | Real estate | 2016 |
| Sheers Gardens Ltd | Administrative & support | 2021 |
| Sheldon Bosley Knight Limited | Real estate | 2016 |
| Shellamar’S Kitchen Ltd | Hospitality | 2024 |
| Shepherd's ROD Ltd | Information & communication | 2026 |
| Sheriffs Lench Barns Management Company Limited | Administrative & support | 2010 |