| Safelink Limited | Hospitality | 2016 |
| Safemobility Solutions Ltd | Wholesale & retail | 2024 |
| Safepath Support Services Ltd | Health & social care | 2025 |
| Safeplan Ltd | Administrative & support | 1997 |
| Safespace Lettings Ltd | Real estate | 2022 |
| Safetan Properties Limited | Real estate | 1998 |
| Safety First Security Ltd | Other services | 2022 |
| Safeway Cars Limited | Wholesale & retail | 1980 |
| Safeway Ventures Limited | Professional & scientific | 2012 |
| Saffron Spoon Ltd | Hospitality | 2025 |
| Saffron Walden Motors Limited | Wholesale & retail | 2004 |
| Saffron Walden Steam Laundry Company Limited | Other services | 1897 |
| Safihealth Ltd | Health & social care | 2025 |
| Safraz & Co Ltd | Real estate | 2007 |
| Sage Realty Solutions Ltd | Real estate | 2025 |
| Sage-Kk Medical Limited | Health & social care | 2014 |
| Saggu Limited | Wholesale & retail | 1998 |
| Sagheer Club Ltd | Wholesale & retail | 2025 |
| Sahajanand Catering Limited | Hospitality | 2020 |
| Sahib Metal Fabrications Limited | Manufacturing | 2022 |
| Sahote Ltd | Professional & scientific | 2004 |
| SAI Consultancy Limited | Information & communication | 2001 |
| Saima Store Limited | Wholesale & retail | 2026 |
| Sainath DO Ltd | Other services | 2026 |
| Sainfoxiya Ltd | Wholesale & retail | 2025 |
| Saira V Ltd | Wholesale & retail | 2025 |
| Saiyette Ltd | Wholesale & retail | 2024 |
| Sajak Investments Ltd | Real estate | 2022 |
| Saldar Engineering Limited | Construction | 2020 |
| Saleglaze Limited | Construction | 1985 |
| Salenzo Ltd | Wholesale & retail | 2025 |
| Salesmix Co Ltd | Wholesale & retail | 2025 |
| Salisbury Snooker Club Limited | Arts & recreation | 1983 |
| Sally Williams Design Ltd | Professional & scientific | 2001 |
| Salma Properties Ltd | Real estate | 2004 |
| Saloin Ltd | Wholesale & retail | 2025 |
| Salsafe Heating Services Limited | Construction | 2021 |
| SAM Bizz Ltd | Wholesale & retail | 2024 |
| SAM Gatward Limited | Administrative & support | 2006 |
| SAM Smyth Projects Limited | Construction | 2019 |
| SAM Sourcing Ltd | Wholesale & retail | 2026 |
| Samalu Limited | Arts & recreation | 2000 |
| Samco Enterprises Limited | Health & social care | 2001 |
| Samford Consultants Ltd | Administrative & support | 2007 |
| Samina Ltd | Wholesale & retail | 2026 |
| Samita Limited | Administrative & support | 2006 |
| Sampan Quantum Solutions Ltd | Information & communication | 2011 |
| Sams Chicken Limited | Wholesale & retail | 2007 |
| SAN London Limited | Real estate | 2022 |
| Sandhu Homes Ltd | Construction | 2021 |
| Sandringham Commodities Limited | Water & waste | 2010 |
| Sandringham Place M.C. Limited | Households | 1994 |
| Sansar Trading Limited | Manufacturing | 2005 |
| Sanson - Fredericks Limited | Professional & scientific | 2026 |
| Sanson Limited | Financial services | 2004 |
| Sapp International Ltd | Wholesale & retail | 2023 |
| Sapurian Limited | Wholesale & retail | 2025 |
| Sara Gregson Marketing Communications Limited | Professional & scientific | 2006 |
| Sarah Musker Ltd | Professional & scientific | 2017 |
| Sarah-M Enterprises Limited | Real estate | 1991 |
| Saralex Consultancy Ltd | Professional & scientific | 2014 |
| Sarfraz Siddique Ltd | Wholesale & retail | 2024 |
| Sartic Ltd | Administrative & support | 2007 |
| Sassi Lift Systems Limited | Wholesale & retail | 1972 |
| Satar (Builders) Limited | | 1976 |
| Sato UK Limited | Manufacturing | 1958 |
| Saudi SIM Ltd | Transport & logistics | 2006 |
| Sauga Ventures Ltd | Wholesale & retail | 2026 |
| Savannah Reads Limited | Wholesale & retail | 2025 |
| Savill ROW (Management) Company Limited | Real estate | 1981 |
| Savills Catering Limited | Hospitality | 2002 |
| Savmore Limited | Wholesale & retail | 1989 |
| Savvy Tax and Accountancy Services Limited | Professional & scientific | 2016 |
| Saxon Transport Limited | | 1976 |
| SB Boulevard Brunch Ltd | Hospitality | 2025 |
| SBF Train Limited | Professional & scientific | 2018 |
| SBK Tuition Limited | Education | 2001 |
| SBM Scotgrain Limited | Manufacturing | 1998 |
| SBS Decorating Ltd | Construction | 2007 |
| SC General Builders Ltd | Construction | 2011 |
| Scandeck Ltd | Construction | 2020 |
| Scass Ltd | Other services | 2004 |
| Scattergood Clements Limited | Other services | 1969 |
| Sceats Family Office Ltd | Professional & scientific | 2024 |
| Sceptra Computer Consultants Limited | Information & communication | 1989 |
| Schoolwear Plus Limited | Wholesale & retail | 2002 |
| Scnn SOL Ltd | Construction | 2025 |
| Scnt Solutions Ltd | Wholesale & retail | 2026 |
| Scoffs (BK) Limited | Hospitality | 2022 |
| Scoffs (CI) Limited | Hospitality | 2023 |
| Scoffs (IU) Ltd | Hospitality | 2023 |
| Scoffs (Miss Millies) Limited | Wholesale & retail | 2022 |
| Scoffs (MU) Ltd | Hospitality | 2023 |
| Scoffs (TB) Limited | Wholesale & retail | 2022 |
| Scoffs (Ventures) Limited | Manufacturing | 2022 |
| Scopex Digital Ltd | Professional & scientific | 2025 |
| Scotgrain Agriculture Limited | Extraterritorial | 1998 |
| Scott Wallis Seeds Limited | Professional & scientific | 1977 |
| Scotts of Marylebone Village Limited | Hospitality | 2025 |
| Scrapx Ltd | Wholesale & retail | 2025 |