| Debut by GH Ltd | Other services | 2024 |
| Decaremasters Ltd | Health & social care | 2020 |
| Deccan Adaptive Intelligence Limited | Information & communication | 2025 |
| Decension Ltd | Information & communication | 2021 |
| Decorheaven Ltd | Wholesale & retail | 2025 |
| Decospan UK Limited | Wholesale & retail | 1987 |
| Deea Pro Edil Ltd | Construction | 2019 |
| Deeba Estates Limited | Real estate | 2025 |
| Deeba Properties Limited | Real estate | 2020 |
| Deedplan Limited | Other services | 2000 |
| Deepdale Management Limited | Information & communication | 1999 |
| Deer Wholesale Ltd | Wholesale & retail | 2026 |
| Defence Secure Services Ltd | Administrative & support | 2023 |
| Defiance Records Ltd | Information & communication | 2024 |
| Degas Limited | | 1978 |
| Deji Lawal Photography Ltd | Professional & scientific | 2022 |
| Dekem Ltd | Real estate | 2022 |
| Dekho.Com Limited | Administrative & support | 2008 |
| Delhi Xpress Limited | Hospitality | 2017 |
| Delice DE Dessert Limited | Hospitality | 2018 |
| Deligoodness Limited | Hospitality | 2022 |
| Delishdiner Limited | Hospitality | 2022 |
| Delmonte Builders Limited | Construction | 1993 |
| Delphini Agencies Limited | Transport & logistics | 1992 |
| Delphu Ltd | Professional & scientific | 2023 |
| Delrem Ltd | Transport & logistics | 2023 |
| Delta Marketing Services Ltd. | Hospitality | 1993 |
| Delta Ventures Ltd | Wholesale & retail | 2023 |
| Deltarock Limited | Real estate | 1993 |
| Deltatex Ltd | Financial services | 2019 |
| Delux Car Valeting Ltd | Other services | 2015 |
| Deluxe Banqueting Hire Limited | Administrative & support | 2009 |
| Delvidere Limited | Professional & scientific | 2007 |
| Demag Plant Hire PLC | Wholesale & retail | 1993 |
| Dempseys Cocktail Bar Limited | Hospitality | 2021 |
| Demur Systems Limited | Professional & scientific | 1997 |
| Demysus Ltd | Information & communication | 2024 |
| Demz Analytics Ltd | Information & communication | 2018 |
| Dennis Court Residents Association Limited | Households | 1976 |
| Dennis Hawkins Eastern Co.Limited | Real estate | 1965 |
| Dentbraces Limited | Health & social care | 2017 |
| Dentelo Ltd | Wholesale & retail | 2022 |
| Dentixone Ltd | Wholesale & retail | 2024 |
| Dents U.K. Ltd | Wholesale & retail | 2004 |
| DEO Gratia Limited | Wholesale & retail | 2025 |
| Dequeen Limited | Administrative & support | 2005 |
| Dereham Road Carwash Ltd | Other services | 2023 |
| Derek Lugg (Painting and Carpentry) Limited | Wholesale & retail | 1984 |
| Derek Taylor Engineering Limited | Manufacturing | 2006 |
| Dermax Ltd | Construction | 2015 |
| Desfer Ltd | Health & social care | 2007 |
| Deshi BD Ltd | Wholesale & retail | 2021 |
| Deshoda Limited | Professional & scientific | 2016 |
| Design & Construct (London) Group Limited | Administrative & support | 2003 |
| Design & Construct (London) Limited | Construction | 1981 |
| Design Bathrooms Limited | | 1987 |
| Design Build & Construct Limited | Construction | 2021 |
| Design Clark Limited | Administrative & support | 2007 |
| Design Engineering and Software Limited | Professional & scientific | 1985 |
| Desolateio Ltd | Information & communication | 2024 |
| Destinolink Ltd | Administrative & support | 2025 |
| Destiny Business Suite Ltd | Wholesale & retail | 2018 |
| Detoxy Bear Ltd | Hospitality | 2024 |
| Deutsch-Chinesische Handelsgesellschaft Ltd | Wholesale & retail | 2023 |
| DEV Engineering UK Limited | Professional & scientific | 2008 |
| Develop Warwickshire LLP | | 2022 |
| Devereux (Essex) Limited | Professional & scientific | 2006 |
| Devereux Residents Management Company Limited | Households | 2004 |
| Devika Property Investments Ltd | Real estate | 2018 |
| Devonshire Hayes Recruitment Specialists Limited | Administrative & support | 2015 |
| Devwood Management Limited | Hospitality | 2019 |
| Dewsbury Associates Limited | Real estate | 2000 |
| DEX Ecom Solutions Ltd | Wholesale & retail | 2025 |
| Deyaz Limited | Wholesale & retail | 2022 |
| DG David Group Ltd | Wholesale & retail | 2026 |
| DG Financial Services Limited | Financial services | 2007 |
| DG Mckelvey Coaching Ltd | Professional & scientific | 2004 |
| DGI Assets Ltd | Real estate | 2025 |
| DGI Portfolio Management Ltd | Real estate | 2025 |
| Dgjw LLP | | 2025 |
| Dhanda Group Limited | Financial services | 2020 |
| Diada Limited | Wholesale & retail | 2026 |
| Dial a Cake Limited | Wholesale & retail | 1998 |
| Dial-A-Spare Limited | Wholesale & retail | 2001 |
| Dialbola Limited | | 1977 |
| Dialectix Company Limited | Information & communication | 2001 |
| Diamond Edge Capital Limited | Financial services | 2005 |
| Diamondcrest Ltd | Health & social care | 2015 |
| Didibits Ltd | Wholesale & retail | 2007 |
| Different by Design Collective CIC | Education | 2025 |
| Digby & Co. (Neckwear) Limited | Manufacturing | 2001 |
| Digi Techhub Ltd | Information & communication | 2025 |
| Digiboostseo Ltd | Wholesale & retail | 2025 |
| Digicopy Limited | Administrative & support | 2002 |
| Digifaz Ltd | Information & communication | 2026 |
| Digimix Ltd | Wholesale & retail | 2022 |
| DIGISOL360 Ltd | Information & communication | 2022 |
| Digit Xpert Ltd | Wholesale & retail | 2023 |
| Digital City Media Limited | Administrative & support | 2013 |
| Digital Intelligence Ltd | Information & communication | 1996 |