| Shetland Pony Club Online Limited | Other services | 2015 |
| Shinrai Karate Limited | Arts & recreation | 2011 |
| Shirley Close (West Lulworth) Management Company Ltd | Hospitality | 2010 |
| Shivshakti Opticians Limited | Health & social care | 2006 |
| Sho-Taurus Ltd | Professional & scientific | 2015 |
| Shpc Limited | Hospitality | 2026 |
| SHX Holdings Ltd | Professional & scientific | 2019 |
| Siam Food Gallery Restaurant LUX Limited | Hospitality | 2013 |
| SID Design Limited | Wholesale & retail | 2013 |
| Silver Psychology Ltd | Hospitality | 2021 |
| Silver Star Global Limited | Financial services | 2022 |
| Silverbear Consultancy Limited | Professional & scientific | 2021 |
| Silvermere Capital Limited | Financial services | 2014 |
| Silverspruce Limited | Professional & scientific | 2011 |
| Simax Property Ltd | Real estate | 2025 |
| Simon Bolton & Associates Ltd | Professional & scientific | 2019 |
| Simon's Court Ltd | Households | 2018 |
| Simple Visa Solutions Limited | Professional & scientific | 2011 |
| Simply ODD Jobs Limited | Construction | 2019 |
| SJF Property Limited | Real estate | 2014 |
| SJS Building Solutions Limited | Construction | 2026 |
| Sk-Ape Media Productions Ltd | Information & communication | 2023 |
| Skeenology Ltd | Other services | 2026 |
| Skills to Influence Ltd | Professional & scientific | 2023 |
| Sklj Limited | Professional & scientific | 2012 |
| Skye Deane Consulting Ltd | Professional & scientific | 2020 |
| Slonecrest LLP | | 2008 |
| SLR Lettings Ltd | Hospitality | 2024 |
| Smart FIX Construction Ltd | Construction | 2025 |
| Smart Glazier Software UK Limited | Information & communication | 2023 |
| Smart People (London) Limited | Professional & scientific | 2008 |
| Smartfill Ltd | Manufacturing | 2021 |
| SMB Productions Ltd | Information & communication | 2022 |
| Smith & Co Consulting Limited | Professional & scientific | 2015 |
| Smith Bernal Family Holdings Limited | Financial services | 2021 |
| Smldigital Limited | Information & communication | 2018 |
| SMP Medical Limited | Health & social care | 2012 |
| Smyle Consulting Ltd | Information & communication | 2010 |
| Snaggle Limited | Real estate | 2001 |
| Snags 1 Limited | Real estate | 2018 |
| SNL Kavanagh Limited | Financial services | 2022 |
| Sockfits Limited | Wholesale & retail | 2020 |
| Softquatra Limited | Information & communication | 2009 |
| Solebay Consultancy Limited | Information & communication | 2015 |
| Solways Limited | Manufacturing | 1967 |
| Sophia Consulting Limited | Professional & scientific | 2008 |
| Sorbo Nine Limited | Professional & scientific | 1929 |
| Sorrento Finance Limited | Financial services | 2025 |
| Sounds Communication Services Ltd | Administrative & support | 2015 |
| South First Street (UK) Holdings Ltd. | Administrative & support | 2019 |
| South Mountain Consulting Ltd | Information & communication | 2010 |
| Speed Air Service Ltd | Professional & scientific | 2024 |
| Spencer Scott Events Limited | Arts & recreation | 2022 |
| Spex Capital Ltd | Financial services | 2021 |
| Spherica Health Consulting Ltd | Professional & scientific | 2016 |
| Spinnaker Capital Solutions Limited | Professional & scientific | 2021 |
| Spiral ARM Studios Ltd | Wholesale & retail | 2012 |
| Spiral Leadership Limited | Professional & scientific | 2013 |
| Spld Surrey Ltd | Education | 2024 |
| Sports Path International Ltd | Arts & recreation | 2004 |
| Springer Strategic Solutions Ltd | Professional & scientific | 2015 |
| SPW Estates Ltd | Real estate | 2008 |
| Srkc Systems Ltd | Professional & scientific | 2025 |
| SRR Talent Spark Limited | Administrative & support | 2024 |
| SSC Consulting Ltd | Information & communication | 2022 |
| SST Real Estate Limited | Real estate | 2023 |
| Stadius Developments Limited | Extraterritorial | 2016 |
| Stadius Limited | Extraterritorial | 1991 |
| Stadius Properties Limited | Extraterritorial | 2016 |
| Stag SEC Ltd | Administrative & support | 2009 |
| Stampr Reward Limited | Information & communication | 2025 |
| Standout Tradesman Limited | Information & communication | 2026 |
| Stanleycoby Consultants Limited | Professional & scientific | 2019 |
| Starbarks Dog Services Ltd | Other services | 2025 |
| Starmeta Limited | Information & communication | 2024 |
| Starting Point Foods Limited | Hospitality | 2022 |
| Stasinnovo Ltd | Wholesale & retail | 2024 |
| Stern Lotion Limited | Administrative & support | 2011 |
| Steve Grant Property Consultants Limited | Other services | 2017 |
| Steve Norton Publishing Limited | Health & social care | 2024 |
| Steven Kane Racing Limited | Administrative & support | 2013 |
| Stevens Lofts Ltd | Construction | 2018 |
| Stewart Thompson Builders Ltd | Construction | 2022 |
| Stone Gallery International Limited | Manufacturing | 2024 |
| Storm Refrigeration Ltd | Manufacturing | 2003 |
| Strength&Co. Limited | Other services | 2026 |
| Strital Consulting Ltd | Professional & scientific | 2021 |
| Struve & Fielding Ltd | Hospitality | 2018 |
| Stuart Smith Property Ltd | Real estate | 2020 |
| Studio "B" Events Limited | Arts & recreation | 2002 |
| Studio Twenty Eight Ltd | Information & communication | 2011 |
| Stuff & Feather Ltd | Wholesale & retail | 2020 |
| SU Properties Limited | Real estate | 2022 |
| Subject EMU Ltd | Information & communication | 2023 |
| Sumou Alasalah International Development Ltd | Construction | 2022 |
| Sun Property (Surrey) Limited | Real estate | 2014 |
| Sunburst Events Limited | Arts & recreation | 2024 |
| Sunbury Manufacturing Co. Limited | Manufacturing | 1994 |
| Sunningdale Corporate Finance Limited | Professional & scientific | 2005 |
| Sunny Dogs Limited | Other services | 2024 |