| SDJ Property Investments Limited | Real estate | 2024 |
| SDL Innovation LLP | | 2023 |
| Sea Algae Limited | Health & social care | 2024 |
| Sea City Crossfit Limited | Arts & recreation | 2017 |
| Sea Dreams Property Ltd | Real estate | 2023 |
| Sea Sure Brighton Community Interest Company | Education | 2019 |
| Sea Way Investments Limited | Real estate | 2022 |
| Sean Buckley Limited | Professional & scientific | 2017 |
| Sean Seal Nwds Limited | Information & communication | 2021 |
| Seaton Holiday Village Limited | Real estate | 2024 |
| Seatoo Barbers Ltd | Other services | 2025 |
| Second Hand Dance Limited | Arts & recreation | 2013 |
| Sedgwick Properties Limited | Construction | 2010 |
| Seeklow Limited | Professional & scientific | 2014 |
| Seeviews Ltd | Professional & scientific | 2022 |
| Sekon Glassworks Ltd. | Manufacturing | 2002 |
| Selborne Place (Weybridge) Management Company Limited | Households | 2010 |
| Selectpractice Limited | Manufacturing | 2025 |
| Self Contained Storage Limited | Transport & logistics | 2026 |
| Sell Textiles Limited | Wholesale & retail | 2001 |
| Selsey Consulting Limited | Professional & scientific | 2017 |
| Semantic Wealth Ltd | Financial services | 2024 |
| Semotis Ltd | Information & communication | 2020 |
| Semper Systems Group Limited | Information & communication | 2024 |
| Sempra Resources Limited | Administrative & support | 2016 |
| Send for Help Limited | Professional & scientific | 2010 |
| Send Surrey Limited | Real estate | 2016 |
| Senior Communications Limited | Professional & scientific | 2003 |
| Senius UK Ltd | Professional & scientific | 2025 |
| Senrab Property Limited | Real estate | 2021 |
| Sensational Kids Ltd | Health & social care | 2008 |
| Sensational Training Limited | Health & social care | 2019 |
| Sentiens Limited | Information & communication | 2018 |
| Sentinel BJJ Ltd | Education | 2025 |
| Sentri Recruitment Ltd | Administrative & support | 2020 |
| Senturk London Ltd | Wholesale & retail | 2025 |
| Senzo City Ltd | Hospitality | 2023 |
| Sepico Ltd | Hospitality | 2021 |
| September Networks Ltd | Other services | 2022 |
| Seren Studio Ltd | Professional & scientific | 2013 |
| Serenity Scapes Limited | Administrative & support | 2023 |
| Serenity Services Limited | Construction | 2015 |
| Servernet Limited | Information & communication | 2009 |
| Service Circles Limited | Real estate | 2003 |
| Service SET Ltd | Information & communication | 2018 |
| Serviceview Limited | Information & communication | 2012 |
| Setbyscales Limited | Administrative & support | 2025 |
| Settledwell Properties Limited | Real estate | 2017 |
| Seven Acre Smallholdings Ltd | Real estate | 2018 |
| Seven Building Services Ltd | Construction | 2018 |
| Seven Hills (Surrey) Limited | Real estate | 2001 |
| Sevenseventysix Limited | Information & communication | 2010 |
| Seventy 2 Construction Ltd | Construction | 2024 |
| SEVENTY6 Communications Ltd | Administrative & support | 2015 |
| Seyicre Ltd | Wholesale & retail | 2025 |
| Seymour Mews (Ewell) Management Company Limited | Households | 1998 |
| SF30 Limited | Administrative & support | 2005 |
| SFC Consulting Services Ltd | Administrative & support | 2019 |
| SFF Properties Limited | Real estate | 2009 |
| SFS Consulting Ltd | Administrative & support | 2025 |
| SG (Thames Ditton) Management Company Limited | Households | 2022 |
| SGC Fencing & Landscaping Ltd | Administrative & support | 2023 |
| SGP Family Limited | Real estate | 2019 |
| SH & P Consulting Limited | Administrative & support | 2020 |
| SH Accounting Services Ltd | Professional & scientific | 2024 |
| Shade Lingerie Limited | Wholesale & retail | 2019 |
| Shadowseed Ltd | Information & communication | 2023 |
| Shah Travels & Tours Ltd | Financial services | 2025 |
| Shaldon Consulting Ltd | Transport & logistics | 2022 |
| Shalini Consultancy Plus Limited | Information & communication | 2014 |
| Shape Planning Consultants Ltd | Professional & scientific | 2025 |
| Shaps Fire Safety Ltd | Professional & scientific | 2026 |
| Shara House Limited | Real estate | 2024 |
| Shared Infrastructures Limited | Professional & scientific | 2021 |
| Shareight Ltd | Wholesale & retail | 2013 |
| Sharp Sphere Ltd | Professional & scientific | 2025 |
| Shayez Edits Ltd | Information & communication | 2024 |
| Shearman Energy Insights Ltd | Professional & scientific | 2021 |
| Shed Disposal UK Ltd | Wholesale & retail | 2015 |
| Sheen Lane Builders Merchants Limited | Wholesale & retail | 2000 |
| Sheffield Commercial Services Ltd | Construction | 2004 |
| Shehata Properties Limited | Real estate | 2021 |
| Shellwood Ltd | Construction | 2020 |
| Shelly Motors Limited | Wholesale & retail | 2006 |
| Shena Enterprises Limited | Information & communication | 2018 |
| Shenfield SPV Limited | Construction | 2026 |
| Shengyuanlu Limited | Hospitality | 2025 |
| Sheni Property Group Ltd. | Real estate | 2022 |
| Sherburne (Leasing) Company Limited | Administrative & support | 1996 |
| Shere Garages Limited | Wholesale & retail | 1988 |
| Sherlock Homes London Limited | Real estate | 2014 |
| Sherpa Property Ltd | Real estate | 2025 |
| Sherriff Close Limited | Real estate | 2021 |
| Shick Esteve UK Ltd | Professional & scientific | 2025 |
| Shik Barbers Limited | Other services | 2022 |
| Shirin Real Estate Ltd | Real estate | 2021 |
| Shirley Heights Management Limited | Households | 1993 |
| Shirley Oaks Management Limited | Households | 1984 |
| Shirley Road Property Ltd | Real estate | 2026 |
| Shoja-R Ltd | Wholesale & retail | 2018 |