| Sally Davies Ltd | Health & social care | 2023 |
| Salt and Pepper Management Ltd. | Professional & scientific | 2015 |
| Salthill Developments Limited | Real estate | 2024 |
| Samee.A Limited | Health & social care | 2026 |
| Sams Acquisitions Ltd | Real estate | 2023 |
| Sandwich Express (Cheshire) Limited | Wholesale & retail | 2011 |
| Sandwich Express Limited | Hospitality | 2021 |
| Sant Group Ltd | Real estate | 2017 |
| Sant Properties Limited | Real estate | 2003 |
| Saph Holdings Ltd | Real estate | 2024 |
| Sassy Doll Ltd | Other services | 2020 |
| Satori People Development Limited | Extraterritorial | 2022 |
| Sauna Cwtch Ltd | Health & social care | 2025 |
| Savas Pizza Kebab House Limited | Hospitality | 2017 |
| Savin Courier Ltd | Transport & logistics | 2025 |
| Saxon Services North West Ltd | Construction | 2015 |
| SBL Print Limited | Manufacturing | 2007 |
| Scaptrani Limited | Real estate | 2020 |
| Scent House Ltd | Administrative & support | 2023 |
| Scja Allen Ltd | Health & social care | 2025 |
| Scope Roof Solutions Limited | Construction | 2017 |
| Sculptori Health Ltd | Professional & scientific | 2024 |
| Seahorse Educational Trust | Education | 2011 |
| Seahr Investments Limited | Professional & scientific | 2025 |
| Sean Green Golf Ltd | Wholesale & retail | 2024 |
| Seancgreengolf Limited | Extraterritorial | 2024 |
| SEE a Way Forward Limited | Health & social care | 2019 |
| Select Investment Property Ltd | Real estate | 2019 |
| Select Mortgages North West Ltd | Financial services | 2014 |
| Select Shipping & Removals Ltd | Transport & logistics | 2023 |
| Seller Global Ltd | Wholesale & retail | 2023 |
| SEN Cleaning Ltd | Administrative & support | 2018 |
| Sendadata Ltd | Information & communication | 2026 |
| Sendashopping Ltd | Other services | 2024 |
| Senovo Health Limited | Professional & scientific | 2018 |
| Sensational Smiles Ltd | Health & social care | 2025 |
| Seranna Ltd | Construction | 2023 |
| Serel Property Ltd | Real estate | 2024 |
| Serve & Social Ltd | Arts & recreation | 2026 |
| Servenet Limited | Information & communication | 2025 |
| Sesh Savers Ltd | Wholesale & retail | 2026 |
| Seven Marketing Agency Ltd | Professional & scientific | 2021 |
| Seven Zinc Ltd | Professional & scientific | 2015 |
| SG Motor Holdings Limited | Administrative & support | 2016 |
| SG Transport (NW) Limited | Professional & scientific | 2019 |
| SGH Swim School LLP | | 2021 |
| SGS MIS Testing Ltd | Professional & scientific | 2013 |
| SGS Quay Pharmaceuticals Limited | Manufacturing | 2001 |
| Sgvu Trading Limited | Wholesale & retail | 2017 |
| Shamo Home Ltd | Real estate | 2023 |
| Sharptrue Engineering Limited | Professional & scientific | 1987 |
| Shaun Holden Life Coaching Limited | Other services | 2021 |
| Shaw Smiles Ltd | Health & social care | 2024 |
| Shawcross Signs Ltd | Manufacturing | 2024 |
| Sheer Media Limited | Professional & scientific | 2009 |
| Sher Builders Ltd | Construction | 2025 |
| Shhf Group Limited | Extraterritorial | 2025 |
| Shhf Properties Limited | Real estate | 2025 |
| Shield Accounting Limited | Professional & scientific | 2025 |
| Shifa Surgical Limited | Health & social care | 2010 |
| Shifted Vision Ltd | Education | 2025 |
| Shoma Ltd | Transport & logistics | 2025 |
| Shopfitting & Building Services Limited | Construction | 2004 |
| Shoplino Limited | Wholesale & retail | 2025 |
| Shorelight Limited | Administrative & support | 2018 |
| Shrla Independent Ltd | Administrative & support | 2023 |
| Shutter BLINDS4U Ltd | Wholesale & retail | 2025 |
| Sierra Property Ltd | Real estate | 2019 |
| Sign Solutions UK Limited | Administrative & support | 2012 |
| Signs 2 Go Limited | Manufacturing | 1993 |
| Sikes-Sheard Limited | Health & social care | 2022 |
| Sikodris Limited | Health & social care | 2025 |
| Silara Tech Ltd | Administrative & support | 2026 |
| Silver ARC Capital Ltd | Real estate | 2025 |
| Silviu RUS Courier Ltd | Other services | 2021 |
| Simco Capital Ltd | Real estate | 2024 |
| Simon Kirkby Limited | Administrative & support | 2014 |
| Simon Martin & Associates Limited | Energy | 2012 |
| Sirch Building Materials Limited | Wholesale & retail | 2016 |
| Sirius Results Ltd | Professional & scientific | 2022 |
| Sisters N Sport International Ltd | Other services | 2016 |
| Sisters N Sport Ltd | Education | 2012 |
| Sisti Dental Care Ltd | Health & social care | 2020 |
| Sivaprime Ltd | Wholesale & retail | 2025 |
| Sivashankar Ltd | Wholesale & retail | 2025 |
| SJ Logendran Ltd | Health & social care | 2026 |
| SJD Gentlemans Barbers Ltd | Other services | 2019 |
| Sjftx Limited | Health & social care | 2024 |
| Sjjb Property Ltd | Real estate | 2021 |
| Sjnlj Limited | Professional & scientific | 2024 |
| Sjph Property Limited | Health & social care | 2026 |
| Skills Inventories Strategies Ltd | Information & communication | 2019 |
| Skye Homes Limited | Administrative & support | 2013 |
| Skyn LAB UK Ltd | Manufacturing | 2018 |
| SL Morris Ltd | Health & social care | 2024 |
| Sldc Property Limited | Real estate | 2025 |
| Slint Engineering Limited | Professional & scientific | 2019 |
| SLL Homes Ltd | Real estate | 2024 |
| Slow Boat Limited | Hospitality | 2001 |
| SM Inspection Ltd | Professional & scientific | 2019 |