| Sentrum Energy LP | | 2012 |
| Senvest LP | | 2015 |
| Senymor Consult LP | | 2014 |
| SEO Builder Ltd | Information & communication | 2009 |
| SEO Digital & Marketing Limited | Information & communication | 2024 |
| SEO Edinburgh Ltd. | Professional & scientific | 2025 |
| Seoalba Ltd | Professional & scientific | 2020 |
| Seolta Spirits Ltd | Manufacturing | 2025 |
| Sepax Holding LP | | 2016 |
| Sepp Associates Limited | Health & social care | 2018 |
| September Studio LP | | 2020 |
| Septiembre LP | | 2004 |
| Septo Alliace LP | | 2015 |
| Sequelgate Technology Solutions Ltd | Information & communication | 2015 |
| Sequoia Finance LP | | 2017 |
| Sequoia Hearne Photography Ltd | Professional & scientific | 2017 |
| Sequoia Michaelsen Partners (SMP) Ltd | Professional & scientific | 2025 |
| Sequoia Shade Productions Ltd | Arts & recreation | 2025 |
| Sequoia Ventures LP | | 2013 |
| SER Financial Services Limited | Professional & scientific | 2013 |
| Sera Yogu Ltd | Real estate | 2024 |
| Seraphim Space Enterprise Investments LP | | 2024 |
| Seraphim Space Opportunities LP | | 2025 |
| Serbert Properties Limited | Real estate | 2017 |
| Serena Archetti Ltd | Education | 2022 |
| Serena Import Export L.P. | | 2010 |
| Serena International Equipment Trading LP | | 2015 |
| Serendipity Investments | | 2008 |
| Serendipity LAB Insight Technologies Ltd | Professional & scientific | 2017 |
| Serene Anaesthetic Services Limited | Health & social care | 2013 |
| Serene BF453 Limited | Administrative & support | 2009 |
| Serene Essence Limited | Health & social care | 2023 |
| Serene Meadows SP | | 2002 |
| Serene Solitude Partners LP | | 2025 |
| Serene Thistle Care Group PVT Ltd | Health & social care | 2025 |
| Serene Tranquility Soundbaths Ltd | Health & social care | 2026 |
| Serenity Business Group LP | | 2021 |
| Serfincorp Finance (Scotland) SP | | 2005 |
| Seria LP | | 2022 |
| Serifes LP | | 2016 |
| Serkland LP | | 2013 |
| Serkles Ltd | Wholesale & retail | 2022 |
| Serleo Limited | Real estate | 2025 |
| Sermat Group | | 1992 |
| Sernasync IT Ltd | Information & communication | 2024 |
| Serpariot Impex LP | | 2012 |
| Serps Invaders Ltd | Professional & scientific | 2010 |
| Serra Company LP | | 2015 |
| Serrou Ltd | Information & communication | 2024 |
| Serserad Limited | Other services | 2025 |
| Sertena Logistic LP | | 2013 |
| Serv Point LP | | 2014 |
| Serv System LP | | 2014 |
| Servex Universal L.P. | | 2010 |
| Service Energy Corporation L.P. | | 2011 |
| Service Operations Ltd | Administrative & support | 2026 |
| Serviced Capital Residencies Ltd | Households | 2026 |
| Serviced Office Group Limited | Real estate | 2023 |
| Servizo International LP | | 2016 |
| Servman Limited | Information & communication | 2012 |
| Servoro Maintenance Services Ltd | Construction | 2025 |
| Servox Holding LP | | 2019 |
| Servtech Worldwide L.P. | | 2011 |
| Servtone Sales LP | | 2013 |
| SES Access & Rigging Ltd | Construction | 2026 |
| SES System L.P. | | 2010 |
| Sesami Europe Ltd | Wholesale & retail | 2004 |
| Sesh Hairdressing Limited | Other services | 2004 |
| SET Wise Ltd | Construction | 2023 |
| Sete Ltd | Hospitality | 2024 |
| Seton Castle New Build Developments Limited | Construction | 2018 |
| Seton Castle Roofing & Building Limited | Construction | 2024 |
| Seton Classic LP | | 2016 |
| Seton East Properties Limited | Real estate | 2020 |
| Setonhill Union LP | | 2014 |
| Setra Logistics LP | | 2011 |
| Sett Studios CIC | Arts & recreation | 2024 |
| Setting Sail LLP | | 2016 |
| Settlement Community Projects C.I.C. | Wholesale & retail | 2020 |
| Setupsale Ltd | Wholesale & retail | 2023 |
| Sevan Drilling Limited | Administrative & support | 2008 |
| Sevel Uruguay LP | | 2023 |
| Seven Domes Limited | Real estate | 2018 |
| Seven Doors | Arts & recreation | 2010 |
| Seven Hills (Edinburgh) LLP | | 2024 |
| Seven Hills Catering Limited | Hospitality | 2014 |
| Seven Hills Fencing Ltd | Manufacturing | 2025 |
| Seven Hills Financial Planning Ltd | Financial services | 2022 |
| Seven Hills Holding Limited | Hospitality | 2017 |
| Seven Hills Investments Limited | Real estate | 2017 |
| Seven Hills Practice Limited | Health & social care | 2013 |
| Seven Hills Property Limited | Construction | 2013 |
| Seven Huts Limited | Wholesale & retail | 2019 |
| Seven Nine Edinburgh Limited | Transport & logistics | 2025 |
| Seven Ocean Pictures (UK) Limited | Arts & recreation | 2025 |
| Seven Sevens Cars Ltd. | Transport & logistics | 2013 |
| Seven Street Wealth Ltd | Financial services | 2000 |
| Sevenmears Ltd | Arts & recreation | 2026 |
| Seventeen Events Management Ltd | Hospitality | 2018 |
| Seventh Kite Ltd | Professional & scientific | 2013 |