| Rumbidzai Limited | Health & social care | 2021 |
| Rumi Properties South Limited | Real estate | 2026 |
| Runcin Ltd | Real estate | 2020 |
| Rund Holdings Limited | Administrative & support | 2008 |
| Rund Limited | Extraterritorial | 2013 |
| Rund Partnership Limited | Professional & scientific | 1997 |
| Running Paws Boarding & Training Ltd | Other services | 2025 |
| Rushstamps (Retail) Limited | Wholesale & retail | 1985 |
| Rustic Roast Catering Ltd | Hospitality | 2024 |
| RWD Automotive Limited | Professional & scientific | 2014 |
| RX Drugs Ltd | Wholesale & retail | 2020 |
| Ryan Edwards Holdings Ltd | Financial services | 2016 |
| Ryan Mundy Farrier Ltd | Agriculture & fishing | 2021 |
| Ryans Estates Ltd | Real estate | 2017 |
| Rymacare Community Limited | Health & social care | 2025 |
| Rymacare Limited | Health & social care | 2016 |
| Ryspeed Transport Limited | Transport & logistics | 2021 |
| S & G Management Ltd | Construction | 1999 |
| S & G Support Limited | Professional & scientific | 2022 |
| S & H Audio Limited | Wholesale & retail | 2005 |
| S & J Bastian Limited | Administrative & support | 2009 |
| S & T Cover Limited | Administrative & support | 1998 |
| S Bennett Consulting Limited | Professional & scientific | 2022 |
| S C Architecture Ltd. | Professional & scientific | 2011 |
| S C Elements Limited | Professional & scientific | 2023 |
| S DOT FE Limited | Wholesale & retail | 2024 |
| S G Bespoke Joinery Limited | Construction | 2016 |
| S G Bespoke Rentals Limited | Real estate | 2019 |
| S Hallum Ltd | Construction | 2021 |
| S I J Limited | Real estate | 2001 |
| S L T Electrical Limited | Construction | 2010 |
| S M Financial Solutions Limited | Financial services | 2021 |
| S Union Pubs Limited | Hospitality | 2025 |
| S&K Healthcare Ltd | Health & social care | 2021 |
| S&N Legacy Holdings Limited | Real estate | 2025 |
| S. Lawford Carpentry Limited | Construction | 2003 |
| S.A. Bailey Cellar Services Limited | Hospitality | 2003 |
| S.E.H. Limited | Professional & scientific | 1990 |
| S.H. Consultancy Services Ltd | Information & communication | 2004 |
| S.J. Philip Limited | Construction | 2000 |
| Saaka Ltd | Wholesale & retail | 2020 |
| Sabertooth Limited | Real estate | 2020 |
| Sabreline Consulting Limited | Manufacturing | 2020 |
| Sabroso Catering Ltd | Hospitality | 2018 |
| SAF Construction & Building Services Ltd | Professional & scientific | 2023 |
| Safe Choice Installations Limited | Construction | 2005 |
| Saffron City Records Ltd. | Information & communication | 2016 |
| Saffronland Group Limited | Health & social care | 2018 |
| Saffronland Homes 1 Limited | Health & social care | 2018 |
| Saffronland Homes 2 Limited | Health & social care | 2018 |
| Saffronland Homes 3 Limited | Health & social care | 2018 |
| Saffronland Investments Limited | Health & social care | 2018 |
| Sago Limited | Wholesale & retail | 2025 |
| Saintdevil Installations Ltd | Construction | 2013 |
| Sakks Menswear Limited | Wholesale & retail | 2005 |
| Sakura Healthcare Limited | Health & social care | 2012 |
| Sales Academy Limited | Administrative & support | 1996 |
| Salisbury Court (Eastleigh) Limited | Households | 1985 |
| Salisbury Dental Care Limited | Health & social care | 2010 |
| Salisbury Gynaecology Limited | Health & social care | 2019 |
| Salisbury Taprooms Limited | Hospitality | 2023 |
| Salon 4 Eleven Limited | Other services | 2020 |
| Salvage Green Limited | Real estate | 2019 |
| SAM and SON Properties Ltd | Construction | 2024 |
| SAM Long Limited | Wholesale & retail | 2008 |
| Sam's Funky FUN Limited | Wholesale & retail | 2015 |
| Sameday Roofing Ltd | Construction | 2025 |
| Sammylinks Limited | Wholesale & retail | 2022 |
| Samuel Charles Glass & Glazing Ltd | Construction | 2020 |
| Samuel James Services Ltd | Construction | 2021 |
| Samuel James Wigs Ltd | Manufacturing | 2019 |
| Samvruddhi Tech SYS Ltd | Information & communication | 2024 |
| Sanday Construction Limited | Construction | 2013 |
| Sanday Developments Limited | Construction | 2020 |
| Sandberg Translation Partners Limited | Professional & scientific | 2000 |
| Sandoe Acoustics Limited | Professional & scientific | 1999 |
| Sandra Reid Ltd | Administrative & support | 2015 |
| Sandysouth Investments Limited | Real estate | 2018 |
| Sangeet Global Limited | Health & social care | 2020 |
| Sankofa Cultural Dance and Performing Arts UK Limited | Arts & recreation | 2026 |
| Sant Jewellers & Sons Limited | Wholesale & retail | 1997 |
| Santorini Aesthetics Ltd | Other services | 2023 |
| Santorini Sun Limited | Other services | 2022 |
| SAP Cutover Ltd | Information & communication | 2024 |
| Sarah Guilder Ltd | Hospitality | 2002 |
| Sarah Huse Beauty Ltd | Other services | 2020 |
| Saran Property Developments Ltd | Construction | 2021 |
| Saran Property Solutions Ltd | Real estate | 2024 |
| Saran Trading Ltd | Financial services | 2024 |
| Sarovi Cloud Limited | Information & communication | 2020 |
| Sarum Private Office LLP | | 2021 |
| SAS Electrical Services Southern Limited | Construction | 2009 |
| SAS Signalling Ltd | Professional & scientific | 2019 |
| Sasfmc Ltd | Real estate | 2019 |
| Satyamsri Ltd | Wholesale & retail | 2026 |
| Sauna Club New Forest Limited | Other services | 2026 |
| Saunders Surfacing Southern Ltd | Construction | 2022 |
| Savvia Technology Limited | Information & communication | 2019 |
| SAW Machinery & Service Ltd | Professional & scientific | 2024 |
| SAW Properties Limited | Real estate | 2016 |