| Read Developments Limited | Real estate | 2004 |
| Reading Tech Cluster | Other services | 2025 |
| Real Life Orthodontics Ltd | Wholesale & retail | 2022 |
| Real Live Magic Productions Ltd | Arts & recreation | 2021 |
| Realise Removals Limited | Transport & logistics | 2021 |
| Realise Solutions (UK) Limited | Administrative & support | 2014 |
| Really Simple Future Limited | Wholesale & retail | 2019 |
| Realredclick Ltd | Information & communication | 2016 |
| Reamplify Ltd | Information & communication | 2024 |
| REC Life Ltd | Manufacturing | 2021 |
| Reclaimhub Ltd | Information & communication | 2014 |
| Reconnect IT Services Ltd | Information & communication | 2024 |
| Recruiting Heads Ltd | Administrative & support | 2023 |
| Red 7 Financial Management Ltd | Financial services | 2015 |
| Red Box Tools & Foam Ltd | Wholesale & retail | 2026 |
| Red Door Communications Ltd | Administrative & support | 2018 |
| Red Herring Ltd | Information & communication | 1996 |
| Red IX Limited | Real estate | 2020 |
| Red Kite Resources Ltd | Information & communication | 2022 |
| Red Panda IT Consulting Ltd | Information & communication | 2025 |
| Red RAW Food, Drink and Cosmetics Ltd | Transport & logistics | 1999 |
| Red RAW Products Ltd | Extraterritorial | 2021 |
| Red Rose Mechanical Services Ltd | Construction | 2013 |
| Red Square Property Developments Ltd | Real estate | 2025 |
| Redefined Electrical & Renewables Ltd | Construction | 2021 |
| Redlane Limited | Construction | 2008 |
| Redspeck Limited | Professional & scientific | 2019 |
| Redwood Motor Company Hampshire Limited | Wholesale & retail | 2019 |
| Rees Leisure Limited | Arts & recreation | 2013 |
| Reform R Pilates Ltd | Arts & recreation | 2026 |
| Regal Estates South Ltd | Real estate | 2025 |
| Regal Homes (Wessex) Limited | Construction | 2003 |
| Regal Homes South Ltd | Real estate | 2017 |
| Regal Lettings Ltd | Real estate | 2026 |
| Regency Heights (Barn Close) Management Company Limited | Households | 2008 |
| Regency Inc. Ltd | Administrative & support | 2025 |
| Regeneration Programme Solutions Limited | Administrative & support | 2021 |
| Reilly JDM Holdings Limited | Financial services | 2014 |
| Reimagine Work Consulting Ltd | Administrative & support | 2025 |
| Rejuvenate by Aimee Carter Limited | Health & social care | 2019 |
| Relevent Consulting Limited | Professional & scientific | 2021 |
| Reliable IT Environments Limited | Information & communication | 2001 |
| Reliant Electric Group Limited | Professional & scientific | 2023 |
| Relife Teque Ltd | Other services | 2024 |
| Relmatech Limited | Information & communication | 2015 |
| Relo Consultancy Ltd | Professional & scientific | 2016 |
| Renegade Bros Talent International Ltd | Professional & scientific | 2025 |
| Renew IT Solutions Limited | Wholesale & retail | 2024 |
| Renown Ltd | Construction | 2019 |
| Rental Direct.Com Limited | Administrative & support | 2020 |
| Renuware Ltd | Wholesale & retail | 2021 |
| Renée Milner Ltd | Professional & scientific | 2024 |
| Repsol Ltd | Construction | 2025 |
| Resolute Elevators Ltd | Manufacturing | 2025 |
| Respure Ltd | Wholesale & retail | 2024 |
| Rest Property Ltd | Real estate | 2018 |
| Restaurant Blaec Ltd | Hospitality | 2025 |
| Restoration Services & Glazing Ltd | Construction | 2022 |
| Results Driven Ltd | Information & communication | 2025 |
| Retrofit Assessors Southern Ltd | Extraterritorial | 2014 |
| Retrofit Wessex Limited | Construction | 2024 |
| Retroroadsports Ltd | Wholesale & retail | 2021 |
| Reuni Ltd | Administrative & support | 2025 |
| Revenger Boat Company Ltd | Manufacturing | 2021 |
| Revilo Limited | Professional & scientific | 2003 |
| Rewind Holdings LLP | | 2023 |
| RFO Holding Limited | Financial services | 2020 |
| RFT Media Ltd | Information & communication | 2025 |
| RGB Media Consulting Limited | Professional & scientific | 2024 |
| RHH Enterprises Ltd | Other services | 2024 |
| Rhinefield Civil Engineering & Construction Limited | Construction | 2012 |
| Rhino Grinding Limited | Other services | 2015 |
| RHK Medical Limited | Health & social care | 2010 |
| Rhoades Rail Ltd | Construction | 2019 |
| Rhodes Geological Consulting Limited | Administrative & support | 2020 |
| Rhodesville Group Ltd | Real estate | 2015 |
| RIB Holdings Ltd | Information & communication | 2011 |
| Ricar Contracts Ltd | Construction | 2025 |
| Ricar Group Ltd | Financial services | 2025 |
| Rich INK Ltd | Other services | 2020 |
| Richard Saunders Building Ltd | Construction | 2022 |
| Richmond Estates 1 Ltd | Real estate | 2026 |
| Ricwin Consultancy Limited | Construction | 2023 |
| Rideride Cycle Workshop Bitterne Limited | Manufacturing | 2026 |
| Ridge Asset Management Ltd | Professional & scientific | 2017 |
| Riguez Ltd | Construction | 2010 |
| Riize TM Ltd | Construction | 2026 |
| Ringfield Limited | Information & communication | 2024 |
| Riomed Limited | Health & social care | 1997 |
| Ripley Motors Ltd | Wholesale & retail | 2016 |
| Rise Lift Services Ltd | Construction | 2014 |
| Riseburn Limited | Information & communication | 2016 |
| Risk and Regulation Analytic Solutions Ltd | Professional & scientific | 2014 |
| Riva South Limited | Transport & logistics | 1989 |
| River Crest Surveyors Ltd | Professional & scientific | 2023 |
| River Hamble Watersports Ltd | Arts & recreation | 2023 |
| Riverbank Four Limited | Extraterritorial | 2023 |
| Riverside Carpentry and Building Limited | Construction | 2015 |
| Riverside Industrial Park Limited | Administrative & support | 2017 |
| Riverside Tattoo Gallery Limited | Other services | 2025 |