| Stephen Offord Coaches Limited | Extraterritorial | 2014 |
| Stephen Rimmer LLP | | 2008 |
| Stephen Spender Trust | Education | 2003 |
| Stephens Property Holdings Ltd | Real estate | 2023 |
| Sterling Maintenance Limited | Manufacturing | 1992 |
| Sterling Removals Limited | Transport & logistics | 2001 |
| Sterling Stock House Ltd | Wholesale & retail | 2026 |
| Sterling Storage Limited | Real estate | 2015 |
| Steve Dabbs Electronics Design Ltd | Professional & scientific | 2018 |
| Steven Parsons Creative Limited | Professional & scientific | 2024 |
| Stevens, Beale & Townsend Limited | Real estate | 2024 |
| Stevensbrown Ltd | Hospitality | 2022 |
| Stewart Brickwork Construction Limited | Administrative & support | 2014 |
| Steyndent Limited | Health & social care | 2006 |
| STL Planning & Design Solutions Ltd | Professional & scientific | 2006 |
| Stockings Farm Limited | Real estate | 2023 |
| Stocks Medical Ltd | Health & social care | 2021 |
| Stoke Nelson Ltd | Health & social care | 2014 |
| Stone Cottage Dental Surgery Ltd | Health & social care | 2025 |
| Stone Cross Builders Ltd | Construction | 2022 |
| Stone Sculpture Exhibition Limited | Arts & recreation | 2017 |
| Stonebridge Eshop Ltd | Wholesale & retail | 2025 |
| Stonechurch Restaurants Limited | Hospitality | 2024 |
| Stonefields Planning Ltd | Professional & scientific | 2024 |
| Stoneflint Ltd | Professional & scientific | 2021 |
| Stonegate Management Limited | Hospitality | 1991 |
| Stonegate Wines Ltd | Wholesale & retail | 2024 |
| Stoneham Hotels Limited | Real estate | 2021 |
| Stonehill Lodges Limited | Hospitality | 2022 |
| Stonewood Consulting Limited | Professional & scientific | 2004 |
| Storage Control Systems Limited | Construction | 2016 |
| Storm Electrical Limited | Construction | 2002 |
| Stormblessed Limited | Health & social care | 2026 |
| Storyscale Limited | Professional & scientific | 2024 |
| STP Critical Care Limited | Health & social care | 2021 |
| Straight Line Consulting Limited | Construction | 2018 |
| Straight Outta Clopton Ltd | Hospitality | 2023 |
| Stranderdize Media Group Ltd | Information & communication | 2020 |
| Strands of Meads Street Ltd | Other services | 2022 |
| Stratford House (Eastbourne) RTM Company Limited | Households | 2017 |
| Strathdon Residents Management Company Limited | Real estate | 2022 |
| Strg Limited | Arts & recreation | 2010 |
| Strictly Immersive Ltd | Arts & recreation | 2021 |
| Strictly School Dancing Limited | Education | 2008 |
| Stripped Ltd | Wholesale & retail | 2025 |
| Strive Project Services Limited | Construction | 2025 |
| Strive Tutors Limited | Education | 2019 |
| Strobe Agency Limited | Administrative & support | 2022 |
| Stromian Properties Ltd | Real estate | 2024 |
| Strong Tower Baptist Church | Other services | 2022 |
| Stronger YOU Gym Limited | Arts & recreation | 2024 |
| Structure and Renewed Energy Ltd | Professional & scientific | 2025 |
| Stuart Carroll Healthcare Consulting Limited | Health & social care | 2021 |
| Stubbs Heating Limited | Construction | 2024 |
| Student Houses (Sussex) Limited | Households | 2017 |
| Studio & Fade Ltd | Other services | 2025 |
| Studio 1 Eastbourne Limited | Real estate | 2024 |
| Studio Adra Ltd | Professional & scientific | 2023 |
| Studio Bosk Limited | Professional & scientific | 2020 |
| Studio Burntwood Limited | Professional & scientific | 2022 |
| Studio Foundling Limited | Arts & recreation | 2025 |
| Studio Juicebox Ltd | Arts & recreation | 2011 |
| Studio Novo Limited | Professional & scientific | 2026 |
| Studio One Fusion Ltd | Other services | 2022 |
| Studio Paradigm Limited | Professional & scientific | 2020 |
| Studio Squeeze Design Ltd | Professional & scientific | 2025 |
| Studioish Limited | Professional & scientific | 2017 |
| Sturm's Autos Limited | Wholesale & retail | 2012 |
| Sturton Place Ltd | Construction | 2019 |
| Stylo Renovations Ltd | Manufacturing | 2013 |
| SU Liverpool Limited | Hospitality | 2024 |
| Subhcommerce Limited | Wholesale & retail | 2025 |
| Success Pyramid Limited | Other services | 2023 |
| Sudeley Advisors Limited | Wholesale & retail | 2023 |
| Sugarcane London Limited | Hospitality | 2007 |
| Suites Direct UK Limited | Hospitality | 2017 |
| Sumly Ltd | Information & communication | 2024 |
| Summer Rain Films Limited | Information & communication | 1998 |
| Summerdown Classic & Sports Cars LLP | | 2014 |
| Summerfield Dental Practice Ltd | Health & social care | 2018 |
| Summit Brickwork Ltd | Construction | 2026 |
| Sun and Moon Health Education CIC | Education | 2019 |
| Sun Convenience Store Limited | Wholesale & retail | 2004 |
| Sunbean Coffee Ltd | Hospitality | 2021 |
| Sunflower Beauty and Massage Ltd | Health & social care | 2022 |
| Sunkin Ltd | Wholesale & retail | 2011 |
| Sunley (Benbow Avenue) Residents Limited | Households | 1988 |
| Sunley (Blakes Way) Residents Limited | Households | 1986 |
| Sunley (Langney Point) Residents Limited | Households | 1987 |
| Sunley (Ramsay Way) Residents Limited | Households | 1986 |
| Sunley (Richmond) Residents Limited | Households | 1989 |
| Sunley (ST. Anthonys) Residents Limited | Households | 1985 |
| Sunner Dkysr Ltd | Real estate | 2026 |
| Sunny Rise Management Company Limited | Real estate | 2008 |
| Sunny Side Cafe Limited | Hospitality | 2016 |
| Sunny Skies Limited | Information & communication | 2011 |
| Sunshine Coast Enterprise Ltd | Other services | 2025 |
| Sunshine Coast Support Limited | Health & social care | 2012 |
| Sunshine Energy Services Limited | Professional & scientific | 2018 |
| Suntis. Limited | Administrative & support | 2025 |