| Forever Smiles Dental Ltd | Health & social care | 2015 |
| Forever Young Longevity Ltd | Other services | 2025 |
| Forge Events Group Ltd | Arts & recreation | 2025 |
| Formcare Investments Limited | Administrative & support | 2014 |
| Formworks (UK) Limited | Real estate | 2000 |
| Forster & Co South East Limited | Administrative & support | 2025 |
| Fort Gate Limited | Real estate | 1972 |
| Fortitude Partnerships Ltd | Wholesale & retail | 2025 |
| Fortress Risk Advisory Ltd | Professional & scientific | 2025 |
| Fortune Avenue Limited | Administrative & support | 2022 |
| Fortunes Always Hiding Limited | Construction | 2001 |
| Fortus Altius Ltd | Wholesale & retail | 2019 |
| Forward Plumbing Services Limited | Construction | 2016 |
| Forwards Group Limited | Financial services | 2024 |
| Foster AV Ltd | Other services | 2024 |
| Foundry Clinic Ltd | Professional & scientific | 2026 |
| Foundry Coffee (Eastbourne) Ltd | Hospitality | 2023 |
| Foundry Coffee Company Ltd | Hospitality | 2021 |
| Foundry Coffee Group Ltd. | Financial services | 2017 |
| Foundry Top Co LLP | | 2022 |
| Fountains RTM Company Limited | Professional & scientific | 2009 |
| Four Seasons Garden Products Limited | Extraterritorial | 1962 |
| Four Seasons Plastics Hastings Limited | Wholesale & retail | 2026 |
| Four Tomatoes Limited | Hospitality | 2023 |
| Fourthcourt Ltd | Professional & scientific | 2013 |
| Fourviere Investments Limited | Real estate | 2024 |
| Fourways Compass Ltd | Households | 2001 |
| Foxton Talent Partners Limited | Administrative & support | 2025 |
| Fractional Staycation Solutions Limited | Real estate | 2024 |
| Francis Clinic Ltd | Other services | 2017 |
| Frank Analysis Ltd | Professional & scientific | 2019 |
| Frank North Brickwork and General Building Limited | Construction | 2008 |
| Fraser Disaster Risk Consulting Ltd | Professional & scientific | 2016 |
| Fred Williamson,& Sons,Limited | Wholesale & retail | 1929 |
| Fredella Property Limited | Real estate | 2021 |
| Freeborn Garages Limited | Wholesale & retail | 1990 |
| Freedom Fields Group Ltd | Other services | 2022 |
| Freedom Fields Holding Ltd | Other services | 2024 |
| Freeland Risk Management Limited | Administrative & support | 2011 |
| Freeman Orthopaedics Ltd | Health & social care | 2019 |
| Freetime Ltd | Information & communication | 2021 |
| French Moments Ltd | Administrative & support | 2016 |
| Frentice Limited | Real estate | 1977 |
| Fresh Activities Ltd | Education | 2014 |
| Fresh Grill Catering Ltd. | Hospitality | 2025 |
| Fresh Space Cleaning Ltd | Administrative & support | 2011 |
| Fresh Start Eastbourne Community Interest Company | Other services | 2023 |
| Freshlandcatering Ltd | Hospitality | 2026 |
| Freshwater Trawlers Ltd | Hospitality | 2023 |
| Fresomi Ltd | Professional & scientific | 2025 |
| FRF Healthcare Ltd | Health & social care | 2020 |
| Friars Lane (Richmond) Management Company Limited | Real estate | 2024 |
| Friendly Ventures Limited | Wholesale & retail | 2020 |
| Friends of Eastbourne Seafront Ltd | Other services | 2022 |
| Frisbymedical Ltd | Health & social care | 2022 |
| Friston Books Ltd. | Information & communication | 2016 |
| Friston Hill Estates Ltd | Real estate | 2019 |
| Fristonia Ltd | Real estate | 2025 |
| Froggle Parties EW Sussex Ltd | Arts & recreation | 2021 |
| Frole Ltd | Other services | 2018 |
| From-To Limited | Professional & scientific | 2014 |
| Frontier Recruitment Limited | Professional & scientific | 2017 |
| Frozen Ice Ltd | Wholesale & retail | 2025 |
| FS Business Solutions Ltd | Professional & scientific | 2017 |
| FSE Productions Limited | Information & communication | 2019 |
| FTF Digital Solutions Ltd | Transport & logistics | 2026 |
| Fuel Matrix Limited | Professional & scientific | 2008 |
| Full Circle Futures Limited | Professional & scientific | 2025 |
| Full Force Solutions Ltd | Real estate | 2024 |
| Full of Faith Ministries International | Other services | 2019 |
| Full-On Racing Ltd | Manufacturing | 2025 |
| Fully Equipped Limited | Professional & scientific | 2004 |
| Fulmer Properties Limited | Real estate | 2019 |
| Funchal Ltd | Wholesale & retail | 2024 |
| Fundamental Life Limited | Administrative & support | 2013 |
| Fundinvoice LLP | | 2013 |
| Fundraising Auctions Limited | Wholesale & retail | 2012 |
| Furze Common Road Ltd | Real estate | 2022 |
| Furzefield Investments Limited | Real estate | 1997 |
| Fusion Electrical Installations Ltd | Construction | 2020 |
| Fusion Inc. Limited | Hospitality | 2017 |
| Fusion Property and Design Ltd | Real estate | 2025 |
| Fussyhen Ltd | Extraterritorial | 2024 |
| Futrballer Ltd | Information & communication | 2026 |
| Future Cherry Limited | Financial services | 2020 |
| Future Displays Limited | Construction | 2025 |
| Future Remodelling Ltd | Construction | 2019 |
| Future South Homes Ltd | Construction | 2022 |
| FVA Projects Ltd | Construction | 2018 |
| G & S Brickwork Limited | Construction | 2002 |
| G and B Brickwork Limited | Construction | 2022 |
| G D Property Limited | Real estate | 2021 |
| G K Prodger Plastering Limited | Construction | 2003 |
| G Newman Ltd | Health & social care | 2022 |
| G. Byrne Limited | Wholesale & retail | 2017 |
| G. H. Auto Engineering Limited | Wholesale & retail | 2004 |
| G.P.H. (York Mansions) Tenants Limited | Households | 1968 |
| G.S.B. Investments Limited | Construction | 1995 |
| GA Technical Ltd | Administrative & support | 2018 |
| GAD Sells Ltd | Wholesale & retail | 2023 |