| Screen Electrical Limited | Manufacturing | 2013 |
| Screen Technology Associates Limited | Professional & scientific | 1997 |
| Scrh Company Limited | Financial services | 2026 |
| Sdgi Ltd | Professional & scientific | 2019 |
| SDM Corporate Travel Limited | Transport & logistics | 1997 |
| SDR Logistics Ltd | Information & communication | 2026 |
| SE Roofing Specialist Ltd | Construction | 2025 |
| Se-Ib Holdings Limited | Financial services | 2016 |
| Seal Plumbing Ltd | Construction | 2026 |
| Seasons Star Ltd | Wholesale & retail | 2023 |
| Second Life Electronics Limited | Other services | 2025 |
| Secure Lifting Services Limited | Construction | 2024 |
| Secure Parcel Solutions Ltd | Construction | 2026 |
| Seecoy Properties Limited | Construction | 2014 |
| Select Equipment Consultants Limited | Wholesale & retail | 2010 |
| Select-Art Interiors Ltd. | Wholesale & retail | 2004 |
| Senabe Ventures Limited | Real estate | 2020 |
| Senia G Ltd | Wholesale & retail | 2015 |
| Seniv Limited | Administrative & support | 2020 |
| SEO360 Solutions Ltd. | Professional & scientific | 2024 |
| Seoprof LLP | | 2025 |
| SEQUENCE5 Limited | Education | 2026 |
| Serene Leisure Ltd | Professional & scientific | 2024 |
| Seven Air Limited | Transport & logistics | 2007 |
| Sezenity Ltd | Health & social care | 2024 |
| SF Commercial Finance Ltd | Financial services | 2017 |
| Shakeel Awan Limited | Wholesale & retail | 2023 |
| Shape Nails and Spa Ltd | Other services | 2026 |
| Sharma Optometry Ltd | Public administration | 2025 |
| Sharphurst Contractors Limited | Construction | 2016 |
| Sharpthorne House Limited | Households | 1986 |
| Sharpthorne Services Ltd | Professional & scientific | 2014 |
| Sheffield Park Management Limited | Households | 1989 |
| Shire Technologies Limited | Extraterritorial | 2025 |
| Shovelstrode Ltd | Arts & recreation | 2017 |
| Shramair Limited | Manufacturing | 2004 |
| SHREDDIN8 Limited | Arts & recreation | 2019 |
| Shreeji Group Limited | Wholesale & retail | 2025 |
| Shreeji Limited | Wholesale & retail | 2020 |
| Shreeji Property Limited | Real estate | 2020 |
| Siamax Agricultural Limited | Agriculture & fishing | 2007 |
| Sidhi Vinayak Hotel Ltd | Hospitality | 2019 |
| Siensi Property Investment Limited | Real estate | 2020 |
| Silco Worldwide Ltd | Transport & logistics | 2016 |
| Silobusters Ltd | Professional & scientific | 2025 |
| Silver Birches Management Company Limited | Extraterritorial | 2006 |
| Silver Grove Ltd | Professional & scientific | 2022 |
| Silvergard Ltd | Wholesale & retail | 2016 |
| Simar Holdings Limited | Transport & logistics | 2015 |
| Simka Ltd | Real estate | 2012 |
| Simple Construction Safety Ltd | Professional & scientific | 2023 |
| Simple Safety Advice Group Limited | Professional & scientific | 2013 |
| Simple Safety Advice Limited | Professional & scientific | 2009 |
| Simply Mots Limited | Wholesale & retail | 2005 |
| Simply Mots Uckfield Limited | Wholesale & retail | 2012 |
| SJ Racing Ltd | Information & communication | 2024 |
| SJ Stroud Heating and Plumbing Limited | Construction | 2016 |
| Sjfm Investments Ltd | Real estate | 2019 |
| SJM 360 Group (UK) Limited | Construction | 2009 |
| SJM 360 Investments (UK) Ltd | Real estate | 2026 |
| SJM Technical Limited | Construction | 2022 |
| SJS Estates Limited | Real estate | 2015 |
| Skala Studio Ltd | Professional & scientific | 2021 |
| Sketchhouse Limited | Arts & recreation | 2017 |
| Skillz (UK) Franchise Limited | Administrative & support | 2022 |
| Skillz (UK) Limited | Arts & recreation | 2015 |
| Skinis Clinic Ltd | Health & social care | 2025 |
| Skylink Aviation Limited | Administrative & support | 2000 |
| SL Network Solutions Limited | Information & communication | 2009 |
| SLF Entertainment Ltd | Information & communication | 2025 |
| Sloane Management Ltd | Professional & scientific | 2025 |
| SM Digital Ltd | Information & communication | 2015 |
| Smada Art Limited | Arts & recreation | 2023 |
| Small Building Works Limited | Construction | 2003 |
| Smart Business Intelligence Limited | Information & communication | 2023 |
| Smart Buyer Ltd | Wholesale & retail | 2021 |
| Smart Link Electrical Ltd | Construction | 2021 |
| Smart Republic Ventures Ltd | Other services | 2018 |
| SMB Leads Investment Ltd | Other services | 2024 |
| Snelsky Limited | Information & communication | 2019 |
| Sngt Consulting Ltd | Professional & scientific | 2017 |
| SNL Consultancy Ltd | Professional & scientific | 2020 |
| SNV Engineering Limited | Construction | 2013 |
| SO Environmental Ltd | Water & waste | 2020 |
| Sociabuild Ltd | Professional & scientific | 2026 |
| Social Living Group Ltd | Administrative & support | 2026 |
| Social Scaffolding Marketing Ltd | Professional & scientific | 2025 |
| Sofalight Limited | Extraterritorial | 1994 |
| Soft Tops Limited | Wholesale & retail | 1999 |
| Solan Fitness East Grinstead Limited | Arts & recreation | 2016 |
| Solar Hive Wholesale Ltd | Wholesale & retail | 2023 |
| Solutions for Sustainability Ltd | Professional & scientific | 2024 |
| Something Sweeet Ltd | Wholesale & retail | 2024 |
| Sonder Counselling Ltd | Health & social care | 2020 |
| Sopa's Beauty of East Grinstead Ltd | Other services | 2018 |
| Sophie Trainor Ltd | Professional & scientific | 2018 |
| SOR Holding (UK) Limited | Real estate | 1995 |
| SORGANIC2024 Ltd | Wholesale & retail | 2024 |
| Sortcode Capital Limited | Financial services | 2023 |
| SOS Detailing Ltd | Wholesale & retail | 2018 |